High throughput screening method of nitric oxide synthase inhibitors and enhancers

Yaoxue Xuebao

Volumn 37, Issue 3, 2002, Pages 161-164

  Sun, Mian En ^a   Chen, Yong Hong ^a   Du, Guan Hua ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Enhancer; High throughput screening; Inhibitor; Nitric oxide synthase (NOS)

Indexed keywords

ARGININE; ENZYME INHIBITOR; N(G) NITROARGININE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE SYNTHASE;

ANIMAL; ARTICLE; CATTLE; DRUG ANTAGONISM; DRUG SCREENING; IN VITRO STUDY; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY;

ANIMALS; ARGININE; CATTLE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; NADP; NITRIC OXIDE SYNTHASE; NITROARGININE;

EID: 0042737691     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Li ZK, Li DD, Yan CH, et al. Research method and technology of nitric oxide and nitric oxide synthase [A]. Zhang JT. Modern Experimental Methods in Pharmacology (SE ft I? S £3e* &) [M]. Beijing: Peking Union Medical College and Beijing Medical University Press, 1997. 2121-2142.
2. Donald WJ, Karen BP, Mahima T, et al. 2-Iminohomopiperdinium salts as selective inhibitors of iNOS [J]. J Med Chem, 1998,41 : 1361-1366.
3. Thomas PM, Roger JS, Daniela S, et al. A fluorometric assay for the measurement of nitrite in biological samples [J]. Anal Biochem , 1993,214 : 11-16.
4. + [J]. Anal Biochem, 1995,227 : 274-280.
5. 15N] nitrate in biological fluids [J]. Anal Biochem, 1982,126 : 131-138.
6. David SB, Solomon HS. Isolation of nitric oxide synthase, a calmodulin-requiring enzyme [J]. Biochemistry, 1990,87 : 682-685.
7. Zulueta JJ, Yu Fs, Herting IA, et al. Release of hydrogen peroxide in response to hypoxia-reoxygenation: role of an NADPH oxidase-like enzyme in endothelial cell plasma membrane [J]. Am J Respir Cell Mol Biol, 1995,12(1) : 41 -49.
8. Indrajit Das, Nusrat SK, Basant KP, et al. Elevated platelet calcium mobilization and nitric oxide synthase activity may reflect abnormalities in schizophrenic brain [J]. Biochem Biophys Res Commun, 1995,212 : 375-380.
9. Hong HJ, Loh SH, Yen MH. Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase [J]. Br J Pharmacol, 2000,131(3) : 631-637 .
10. Marrogi A, Pass HI, Khan M, et al. Human mesothelioma sample overexpress both cyclooxygenase-2 and inducible nitric oxide synthase: in vitro antiproliferative effects of a COX-2 inhibitor [J]. Cancer Res, 2000,60(14) : 3696-3700.
11. O'Neil MJ, Murray TK, McCarty DR, et al. ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia [J]. Brain Res, 2000,871(2) : 234-244.
12. Al-Shabanah OA, Alam K, Nagi MN, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice [J]. Life Sci, 2000,66(3) : 265-270.