A pharmacophore model for sulphonyl-urea (-cyanoguanidine) compounds with dual action, thromboxane receptor antagonists and thromboxane synthase inhibitors

European Journal of Medicinal Chemistry

Volumn 38, Issue 7-8, 2003, Pages 703-710

  Michaux, Catherine ^a   Dogné, Jean Michel ^b   Rolin, Stéphanie ^a   Masereel, Bernard ^a   Wouters, Johan ^a,c   Durant, François ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c IRMW   (Belgium)

Author keywords

Catalyst hypothesis; Pharmacophore; Sulphonyl urea ( cyanoguanidine) ligand; Thromboxane receptor antagonism; Thromboxane synthase inhibition

Indexed keywords

AROMATIC COMPOUND; FUNCTIONAL GROUP; GUANIDINE DERIVATIVE; N ISOPROPYL N' [[2 (3' METHYLPHENYLAMINO) 5 NITROBENZENE]SUFONYL]UREA; N PENTYL N' [(2 CYCLOHEXYLAMINO 5 NITROBENZENE)SULFONYL]UREA; N TERT BUTYL N' [(2 CYCLOHEXYLAMINO 5 NITROBENZENE)SULFONYL]UREA; N TERT BUTYL N' [[2 (4' METHYLPHENYLAMINO) 5 NITROBENZENE]SULFONYL]UREA; SULFONYLUREA DERIVATIVE; THROMBOXANE RECEPTOR BLOCKING AGENT; THROMBOXANE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; PHARMACOPHORE; STRUCTURE ANALYSIS;

EID: 0042657907     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00076-X     Document Type: Article

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