Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 15, 1998, Pages 1943-1948

  Takeuchi, Kumiko ^a   Kohn, Todd J ^a   Mais, Dale E ^a,b   True, Timothy A ^a,c   Wyss, Virginia L ^a   Jakubowski, Joseph A ^a  

^a ELI LILLY AND COMPANY   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; OXAZOLE; OXAZOLE DERIVATIVE; THROMBOXANE A2; THROMBOXANE RECEPTOR; THROMBOXANE RECEPTOR BLOCKING AGENT; THROMBOXANE SYNTHASE; THROMBOXANE SYNTHASE INHIBITOR;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; LIPOPHILICITY; RECEPTOR BLOCKING;

DRUG DESIGN; ENZYME INHIBITORS; RECEPTORS, THROMBOXANE; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOXANE-A SYNTHASE;

EID: 0032483064     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00353-9     Document Type: Article

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