Effect of intragranular porosity on compression behaviour of and drug release from reservoir pellets

European Journal of Pharmaceutical Sciences

Volumn 19, Issue 5, 2003, Pages 333-344

  Tunón, Åsa ^a   Gråsjö, Johan ^a   Alderborn, Göran ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Deformation; Densification; Drug release; Extrusion spheronisation; Intragranular porosity; Reservoir pellet

Indexed keywords

CELLULOSE; COATINGS; COMPACTION; CRYSTALLINE MATERIALS; DEFORMATION; POROSITY; SPRAYING;

RESERVOIR PELLETS;

DRUG PRODUCTS;

ETHYL CELLULOSE; MICROCRYSTALLINE CELLULOSE; SALICYLIC ACID;

ARTICLE; DRUG COATING; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RELEASE; PELLET EXTRUSION; POROSITY; PRIORITY JOURNAL; SPHERONIZATION; SURFACE PROPERTY; TABLET;

EID: 0042626022     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00106-4     Document Type: Article

References (37)

1. Aulton M.E., Dyer A.M., Khan K.A. The strength and compaction of millispheres. The design of a controlled-release drug delivery system for ibuprofen in the form of a tablet comprising compacted polymer-coated millispheres. Drug Dev. Ind. Pharm. 20:1994;3069-3104.
2. Beckert T.E., Lehmann K., Schmidt P.C. Compression of enteric-coated pellets to disintegrating tablets. Int. J. Pharm. 143:1996;13-23.
3. Bodmeier R. Tableting of coated pellets. Eur. J. Pharm. Biopharm. 43:1997;1-8.
4. Chopra R., Alderborn G., Podczeck F., Newton J.M. The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets. Int. J. Pharm. 239:2002;171-178.
5. Cox E.P. A method of assessing numerical and percentage values to the degree of roundness of sand grains. J. Paleontol. 1:1927;179-183.
6. Eriksson M., Nyström C., Alderborn G. The use of air permeametry for the assessment of external surface area and sphericity of pelletized granules. Int. J. Pharm. 99:1993;197-207.
7. Felton L.A., Shah N.H., Zhang G., Infeld M.H., Malick A.W., McGinity J.W. Compaction properties of individual nonpareil beads coated with an acrylic resin copolymer. S.T.P. Pharma Sci. 7:1997;457-462.
8. Habib Y.S., Augsburger L.L., Shangraw R.F. Production of inert cushioning beads: effect of excipients on the physicomechanical properties of freeze-dried beads containing microcrystalline cellulose produced by extrusion-spheronization. Int. J. Pharm. 233:2002;67-83.
9. Haslam J.L., Forbes A.E., Rork G.S., Pipkin T.L., Slade D.A., Khossravi D. Tableting of controlled release multiparticulates, the effect of millisphere size and protective overcoating. Int. J. Pharm. 173:1998;233-242.
10. Heywood H. Particle shape coefficients. J. Imp. Coll. Chem. Eng. Soc. 8:1954;25-33.
11. Iloañusi N.O., Schwartz J.B. The effect of wax on compaction of microcrystalline cellulose beads made by extrusion and spheronization. Drug Dev. Ind. Pharm. 24:1998;37-44.
12. Jerwanska E., Alderborn G., Newton J.M., Nyström C. The effect of water content on the porosity and liquid saturation of extruded cylinders. Int. J. Pharm. 121:1995;65-71.
13. Johansson B., Alderborn G. Degree of pellet deformation during compaction and its relationship to the tensile strength of tablets formed of microcrystalline cellulose pellets. Int. J. Pharm. 132:1996;207-220.
14. Johansson B., Alderborn G. The effect of shape and porosity on the compression behaviour and tablet forming ability of granular materials formed from microcrystalline cellulose. Eur. J. Pharm. Biopharm. 52:2001;347-357.
15. Johansson B., Wikberg M., Ek R., Alderborn G. Compression behaviour and compactability of microcrystalline cellulose pellets in relationship to their pore structure and mechanical properties. Int. J. Pharm. 117:1995;57-73.
16. Lundqvist Å.E.K., Podczeck F., Newton J.M. Influence of disintegrant type and proportion on the properties of tablets produced from mixtures of pellets. Int. J. Pharm. 147:1997;95-107.
17. Lundqvist Å.E.K., Podczeck F., Newton J.M. Compaction of, and drug release from, coated drug pellets mixed with other pellets. Eur. J. Pharm. Biopharm. 46:1998;369-379.
18. Maganti L., Çelik M. Compaction studies on pellets II. Coated pellets. Int. J. Pharm. 103:1994;55-67.
19. Mehta K.A., Kislalioglu M.S., Phuapradit W., Malick A.W., Shah N.H. Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug. J. Control. Release. 63:2000;201-211.
20. Millili G.P., Schwartz J.B. The strength of microcrystalline cellulose pellets: the effect of granulating with water/ethanol mixtures. Drug Dev. Ind. Pharm. 16:1990;1411-1426.
21. Mount D.L., Schwartz J.B. Formulation and compaction of nonfracturing deformable coated beads. Drug Dev. Ind. Pharm. 22:1996;609-621.
22. Nicklasson F., Alderborn G. Modulation of the tabletting behaviour of microcrystalline cellulose pellets by the incorporation of polyethylene glycol. Eur. J. Pharm. Sci. 9:1999;57-65.
23. Nicklasson F., Alderborn G. Analysis of the mechanics of pharmaceutical agglomerates of different porosity and composition using the Adams and Kawakita equations. Pharm. Res. 17:2000;947-952.
24. Nyström C., Stanley-Wood N. Measurement of particle size of free-flowing material with a ring gap sizer. Acta Pharm. Suec. 13:1976;277-284.
25. Pinto J.F., Podczeck F., Newton J.M. Investigations of tablets prepared from pellets produced by extrusion and spheronisation. Part I: The application of canonical analysis to correlate the properties of the tablets to the factors studied in combination with principal component analysis to select the most relevant factors. Int. J. Pharm. 147:1997;79-93.
26. Pinto J.F., Podczeck F., Newton J.M. The use of statistical moment analysis to elucidate the mechanism of release of a model drug from pellets produced by extrusion and spheronisation. Chem. Pharm. Bull. 45:1997;171-180.
27. Podczeck F. Comparison of in vitro dissolution profiles by calculating mean dissolution time (MDT) or mean residence time (MRT). Int. J. Pharm. 97:1993;93-100.
28. Press W.H., Teukolsky S.A., Vetterling W.T., Flannery B.P. 2nd Edition Numerical Recipes in C. The Art of Scientific Computing. 1992;132 The Press Syndicate of the University of Cambridge, Cambridge.
29. Ragnarsson G., Sandberg A., Jonsson U.E., Sjögren J. Development of a new controlled release metoprolol product. Drug Dev. Ind. Pharm. 13:1987;1495-1509.
30. Salako M., Podczeck F., Newton J.M. Investigations into the deformability and tensile strength of pellets. Int. J. Pharm. 168:1998;49-57.
31. Sarisuta N., Punpreuk K. In vitro properties of film-coated diltiazem hydrochloride pellets compressed into tablets. J. Control. Release. 31:1994;215-222.
32. Schwartz J.B., Nguyen N.H., Schnaare R.L. Compaction studies on beads: compression and consolidation parameters. Drug Dev. Ind. Pharm. 20:1994;3105-3129.
33. Tunón Å. Preparation of Tablets from Reservoir Pellets with an Emphasis on the Compression Behaviour and Drug Release. 2003;Uppsala University, Sweden. Ph.D. Thesis.
34. Tunón Å., Alderborn G. Granule deformation and densification during compression of binary mixtures of granules. Int. J. Pharm. 222:2001;65-76.
35. Vergote G.J., Kiekens F., Vervaet C., Remon J.P. Wax beads as cushioning agents during the compression of coated diltiazem pellets. Eur. J. Pharm. Sci. 17:2002;145-151.
36. Wagner K.G., Krumme M., Schmidt P.C. Pellet-containing tablets. Examination of distribution and deformation behaviour. S.T.P. Pharma Sci. 10:2000;327-334.
37. Wang C., Zhang G., Shah N.H., Infeld M.H., Malick A.W., McGinity J.W. Compaction properties of spheronized binary granular mixtures. Drug Dev. Ind. Pharm. 21:1995;753-779.