The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets

International Journal of Pharmaceutics

Volumn 239, Issue 1-2, 2002, Pages 171-178

  Chopra, Ranjana ^a   Alderborn, Göran ^b   Podczeck, Fridrun ^a   Newton, J Michael ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Drug release; Film coating; Mean dissolution time; Pellet porosity; Pellet shape; Pellet surface area; Relative dispersion coefficient

Indexed keywords

ETHYL CELLULOSE; POVIDONE;

ARTICLE; COATED PARTICLE; DISPERSION; DISSOLUTION; DRUG MANUFACTURE; DRUG PELLET; DRUG RELEASE; FILM COATING; LIQUID; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; SPHERONIZATION; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; THICKNESS;

ALGORITHMS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; PIROXICAM; SOLUBILITY; SOLVENTS; SULFONAMIDES;

EID: 0037018965     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00104-7     Document Type: Article

References (8)

1. Preparation of pellets of different shape and their characterisation
2. The influence of film coating on pellet properties
3. Methode zur Bestimmung von Reaktionsordnungen und Reaktionsgeschwindigkeitskonstanten
4. The effect of particle size and shape on the surface specific dissolution rate of micronized practically insoluble drugs
5. Dissolution rate studies. II. Dissolution of particles under conditions of rapid agitation
6. Comparison of in vitro dissolution profiles by calculating mean dissolution time (MDT) or mean residence time (MRT)
7. The evaluation of a three-dimensional shape factor for the quantitative assessment of the sphericity and surface roughness of pellets
8. Modelling of input function to drug absorption by moments