Three dimensional structures of S189D chymotrypsin and D189S trypsin mutants: The effect of polarity at site 189 on a protease-specific stabilization of the substrate-binding site

Journal of Molecular Biology

Volumn 331, Issue 5, 2003, Pages 1121-1130

  Szabó, Erika ^a,b   Venekei, István ^a   Böcskei, Zsolt ^a,c   Náray Szabó, Gábor ^a   Gráf, László ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b SZENT ISTVÁN UNIVERSITY   (Hungary)

^c SANOFI   (France)

Author keywords

Active site polarity; Chymotrypsin; Specificity site stabilization; Trypsin; X ray crystallography

Indexed keywords

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONFORMATION; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME STABILITY; GENE STRUCTURE; MUTANT; PRIORITY JOURNAL; PROBABILITY; PROTEIN STRUCTURE; REACTION ANALYSIS; WILD TYPE;

EID: 0042622558     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00849-0     Document Type: Article

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