Identification of two novel CT antigens and their capacity to elicit antibody response in hepatocellular carcinoma patients

British Journal of Cancer

Volumn 89, Issue 2, 2003, Pages 291-297

  Dong, X Y ^a   Su, Y R ^a   Qian, X P ^a   Yang, X A ^a   Pang, X W ^a   Wu, H Y ^a   Chen, W F ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Antibody response; CT antigen; Hepatocellular carcinoma

Indexed keywords

COMPLEMENTARY DNA; FATE ANTIGEN; ISOPROTEIN; MESSENGER RNA; TPTE ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ARTICLE; CANCER PATIENT; COLON CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; EXON; FATE GENE; GENE; GENE EXPRESSION PROFILING; GENETIC SIMILARITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN VARIANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SCREENING TEST; TISSUE SECTION; TPTE GENE;

ANTIBODY FORMATION; ANTIGENS, NEOPLASM; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; DATABASES, FACTUAL; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MEMBRANE PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-TYROSINE-PHOSPHATASE; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0042622264     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601062     Document Type: Article

References (31)

1. Aylwin SJ, Welch JP, Davey CL, Geddes JF, Wood DF, Besser GM, Grossman AB, Monson JP, Burrin JM (2001) The relationship between steroidogenic factor 1 and DAX-1 expression and in vitro gonadotropin secretion in human pituitary adenomas. J Clin Endocrinol Metab 86: 2476-2483
2. Baba T, Niida Y, Michikawa Y, Kashiwabara S, Kodaira K, Takenaka M, Kohno N, Gerton GL, Arai Y (1994) An acrosomal protein, sp32, in mammalian sperm is a binding protein specific for two proacrosins and an acrosin intermediate. J Biochem 269: 10133-10140
3. Bamberger AM, Ezzat S, Cao B, Wong M, Parker KL, Schulte HM, Asa SL (1996) Expression of steroidogenic factor-1 (SF-1) mRNA and protein in the human placenta. Mol Hum Reprod 2: 457-461
4. Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (1997) The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. Hum Mol Genet 6: 1559-1564
5. Chen H, Rossier C, Morris MA, Scott HS, Gos A, Bairoch A, Antonarakis SE (1999) A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. Hum Genet 105: 399-409
6. Chen YT, Boyer AD, Viars CS, Tsang S, Old LJ, Arden KC (1997a) Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28. Cytogenet Cell Genet 79: 237-240
7. Chen YT, Scanlan MJ, Sahin U, Türeci Ö, Güre AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ (1997b) A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci USA 94: 1914-1918
8. De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, van der Bruggen P, Lethe B, Lurquin C, Brasseur R, Chomez P, De Backer O, Cavenee W, Boon T (1994) Structure, chromosomal localization, and expression of 12 genes of the MAGE family. Immunogenetics 40: 360-369
9. Giorgio P, Marialuisa S, Chiara C, Licia R, Andrea A (2002) T-cell response to unique and shared antigens and vaccination of cancer patients. Cancer Immunity 2: 6
10. Güre AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT (2000) CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational difference analysis. Int J Cancer 85: 726-732
11. Güre AO, Türeci Ö, Sahin U, Tsang S, Scanlan MJ, Jager E, Knuth A, Pfreundschuh M, Old LJ, Chen YT (1997) SSX, a multigene family with several members transcribed in normal testis and human cancer. Int J Cancer 72: 965-971
12. Heyting C (1996) Synaptonemal complexes: structure and function. Curr Opin Cell Biol 8: 389-396
13. Jager D, Jager E, Knuth A (2001) Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer. J Clin Pathol 54: 669-674
14. Kirkin AF, Dzhandzhugazyan KN, Zeuthen J (2002) Cancer/testis antigens: structural and immunobiological properties. Cancer Invest 20: 222-236
15. Lopez D, Sandhoff TW, McLean MP (1999) Steroidogenic factor-1 mediates cyclic 3′,5′-adenosine monophosphate regulation of the high density lipoprotein receptor. Endocrinology 140: 3034-3044
16. Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378
17. Martelange V, De Smet C, De Palen E, Lurquin C, Boon T (2000) Identification on a human sarcoma of two new genes with tumor-specific expression. Cancer Res 60: 3848-3855
18. Menke AL, van der Eb AJ, Jochemsen AG (1998) The Wilms' tumor 1 gene: oncogene or tumor suppressor gene? Int Rev Cytol 181: 151-212
19. Oka Y, Tsuboi A, Elisseeva OA, Udaka K, Sugiyama H (2002) WT1 as a novel target antigen for cancer immunotherapy. Curr Cancer Drug Targets 2: 45-54
20. Okuda K (1992) Hepatocellular carcinoma: recent progress. Hepatology 15: 948-963
21. Olesen C, Larsen NJ, Byskov AG, Harboe TL, Tommerup N (2001) Human FATE is a novel X-linked gene expressed in fetal and adult testis. Mol Cell Endocrinol 184: 25-32
22. Sahin U, Türeci Ö, Schmitt, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I, Pfreundschuh M (1995) Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 92: 11810-11813
23. Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ, Reed MW (2000) Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal Biochem 285: 194-204
24. Schuler GD (1997) Pieces of the puzzle: expressed sequence tags and the catalog of human genes. J Mol Med 75: 694-698
25. Sugiyama H (2001) Wllms' tumor gene WT1: its oncogenic function and clinical application. Int J Hematol 73: 177-187
26. Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354
27. Tureci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M (1998) Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens. Proc Natl Acad Sci USA 95: 5211-5216
28. Velculescu VE, Zhang L, Vogelstein B, Kinzler KW (1995) Serial analysis of gene expression. Science 270: 484-487
29. Wu Y, Dowbenko D, Pisabarro MT, Dillard-Telm L, Koeppen H, Lasky LA (2001) PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase. J Biol Chem 276: 21745-21753
30. Wang Y, Han KJ, Pang XW, Vaughan HA, Qu w, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF (2002) Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. J Immunol 169: 1102-1109
31. Zendman AJ, Cornelissen IM, Weidle UH, Ruiter DJ, van Muijen GN (1999) CTp11, a novel member of the family of human cancer/testis antigens. Cancer Res 59: 6223-6239