The relationship between steroidogenic factor 1 and DAX-1 expression and in vitro gonadotropin secretion in human pituitary adenomas

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 6, 2001, Pages 2476-2483

  Aylwin, S J B ^a   Welch, J P ^a   Davey, C L ^a   Geddes, J F ^a   Wood, D F ^a   Besser, G M ^a   Grossman, A B ^a   Monson, J P ^a   Burrin, J M ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; FOLLITROPIN; LUTEINIZING HORMONE; MESSENGER RNA; STEROIDOGENIC FACTOR 1;

ALPHA CHAIN; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FOLLITROPIN RELEASE; GENE EXPRESSION; GONADOTROPIN RELEASE; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; PROLACTINOMA; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOMA; DNA-BINDING PROTEINS; FUSHI TARAZU TRANSCRIPTION FACTORS; GONADOTROPINS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; PITUITARY NEOPLASMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; REFERENCE VALUES; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0034971508     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.6.2476     Document Type: Article

References (37)

1. Anterior pituitary development: Short tales from dwarf mice
2. How many homeobox genes does it take to make a pituitary gland?
3. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene Pit-1
4. Pit-1 determines cell types during development of the anterior pituitary gland
5. Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: Potential links in endocrine development
6. The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis
7. The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone α-subunit gene in pituitary gonadotropes
8. Stimulation of luteinizing hormone β gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1
9. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
10. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
11. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism
12. A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal
13. Expression of DAX-1, the gene responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism, in the hypothalamic-pituitary-adrenal/gonadal axis
14. The murine DAX-1 promoter is stimulated by SF-1 and inhibited by COUP-TEE via a composite nuclear receptor-regulatory element
15. DAX-1 inhibits SEE-1-mediated transactivation via a carboxyterminal domain that is deleted in adrenal hypoplasia congenita
16. Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
17. The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph
18. Follicle stimulating hormone-β subunit gene is expressed in parallel with a transcription factor Ad4BP/SF-1 in human pituitary adenomas
19. Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas
20. Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone α-subunit promoter
21. Activation of the glycoprotein hormone α-subunit gene promoter in thyrotropes
22. Growth hormone secreting pituitary adenomas are heterogeneous in cell culture and commonly secrete glycoprotein hormone alpha-subunit
23. Glycoprotein hormone alpha subunit and prolactin release by cultured pituitary adenoma cells from acromegalic patients. Correlation with GH release
24. Hormone secretion in vitro by plurihormonal pituitary adenomas of the acidophil cell line
25. Free alpha subunit and intact TSH secretion are closely associated in somatotroph adenomas
26. Pituitary cells producing more than one hormone: Human pituitary adenomas
27. Glycoprotein hormone α-subunit production and plurihormonality in human pituitary corticotroph tumours - An in vitro and immunohistochemical study
28. Cell specific expression of estrogen receptor in the human pituitary and its adenomas
29. A Steroidogenic factor-1 binding site is required for activity of the luteinizing hormone β-subunit promoter in gonadotropes of transgenic mice
30. Steroidogenic factor-1 (SF-1) and the regulation of expression of luteinising hormone and follicle stimulating β-subunits in the sheep anterior pituitary in vivo
31. X-linked adrenal hypoplasia congenita: A mutation in DAX-1 expands the phenotypic spectrum in males and females
32. Steroidogenic factor 1: A key determinant of endocrine development and function
33. The role of DAX-1 in reproduction
34. Clinically nonfunctioning pituitary tumors are monoclonal in origin
35. A novel type of pituitary adenoma: Morphological features and clinical correlations
36. The role of transcription factors in the pituitary expression of the glycoprotein hormone alpha subunit gene
37. Inhibition of alpha subunit expression in somatomammotropic pituitary cells