Increasing dietary linoleic acid in young rats increases and then decreases docosahexaenoic acid in retina but not in brain

Lipids

Volumn 31, Issue 12, 1996, Pages 1289-1298

  Su, Hui Min ^a   Keswick, Lisa A ^a   Brenna, J Thomas ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; UNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DIET; FAT INTAKE; FEMALE; LACTATION; LIPID BLOOD LEVEL; LIPID BRAIN LEVEL; LIPID COMPOSITION; LIPID LIVER LEVEL; MILK LEVEL; NEWBORN; NONHUMAN; RAT; RETINA DEVELOPMENT;

ANIMALS; BRAIN; DIETARY FATS, UNSATURATED; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS; FEMALE; LINOLEIC ACID; LINOLEIC ACIDS; LIVER; MILK; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RETINA;

ANIMALIA;

EID: 0030447875     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02587915     Document Type: Article

References (46)

1. Fliesler, S.J., and Anderson, R.E. (1983) Chemistry and Metabolism of Lipids in the Vertebrate Retina, Prog. Lipid Res. 22, 79-131.
2. Sastry, P.S. (1985) Lipids of Nervous Tissue: Composition and Metabolism, Prog. Lipid Res. 24, 69-176.
3. Dobbing, J., and Sands, J. (1979) Comparative Aspects of the Brain Growth Spurt, Early Hum. Dev. 3, 79-83.
4. Sinclair, A.J., and Crawford, M.A. (1972) The Accumulation of Arachidonate and Docosahexaenoate in the Developing Rat Brain, J. Neurochem 19, 1753-1758.
5. Martinez, M. (1992) Tissue Levels of Polyunsaturated Fatty Acids During Early Human Development, J. Pediatr. 120, S129-S138.
6. Dobbing, J., and Sands, J. (1971) Vulnerability of Developing Brain, Biol. Neonate 19, 363-378.
7. Neuringer, M., Connor, W.E., Lin, D.S., Barstad, L., and Luck, S. (1986) Biochemical and Functional Effects of Prenatal and Postnatal Omega-3 Fatty-Acid Deficiency on Retina and Brain in Rhesus Monkeys, Proc. Natl. Acad. Sci. U.S.A. 83, 4021-4025.
8. Uauy, R., and Hoffman, D.R. (1991) Essential Fatty Acid Requirements for Normal Eye and Brain Development, Seminars in Perinat. 15, 449-455.
9. Alling, C., Bruce, A., Karlsson, I., Sapia, O., and Svennerholm, L. (1972) Effect of Maternal Essential Fatty Acid Supply on Fatty Acid Composition of Brain, Liver, Muscle and Serum in 21-Day-Old Rats. J. Nutr. 102, 773-782.
10. Crawford, M.A., Hassam, A.G., and Williams, G. (1976) Essential Fatty Acids and Fetal Brain Growth, Lancet, 452-453.
11. Bourre, J.M., Pascal, G., Durand, G., Masson, M., Dumont, O., and Piciotti, M. (1984) Alterations in the Fatty Acid Composition of Rat Brain Cells (Neurons, Astrocytes, and Oligodendrocytes) and of Subcellular Fractions (Myelin and Synaptosomes) Induced by a Diet Devoid of n-3 Fatty Acids, J. Neurochem 43, 342-348.
12. Bourre, J.M., Francois, M., Youyou, A., Dumont, O., Piciotti, M., Pascal, G., and Durand, G. (1989) The Effects of Dietary α-Linolenic Acid on the Composition of Nerve Membranes Enzymatic Activity Amplitude of Electrophysiological Parameters Resistance to Poisons and Performance of Learning Tasks in Rats, J. Nutr. 119, 1880-1892.
13. Neuringer, M., Connor, W.E., Petten, C.V., and Barstad, L. (1984) Dietary Omega-3 Fatty Acid Deficiency and Visual Loss in Infant Rhesus Monkeys, J. Clin. Invest. 73, 272-276.
14. Yamamoto, N., Saitoh, M., Moriuchi, A., Nomura, M., and Okuyama, H. (1987) Effect of Dietary α-Linolenate-Linoleate Balance on Brain Lipid Compositions and Learning Ability of Rats, J. Lipid Res. 28, 144-151.
15. Sanders, T.A.B., and Rana, S.K. (1987) Comparison of the Metabolism of Linoleic and α-Linolenic Acids in the Fetal Rat, Ann. Nutr. Metab. 31, 349-353.
16. Cook, H.W. (1978) In Vitro Formation of Polyunsaturated Fatty Acids by Desaturation in Rat Brain: Some Properties of the Enzymes in Developing Brain and Comparisons with Liver, J. Neurochem. 30, 1327-1334.
17. Brenner, R.R., and Peluffo, R.O. (1966) Effect of Saturated and Unsaturated Fatty Acids on the Desaturation in vitro of Palmitic, Stearic. Oleic, Linoleic and α-Linolenic acids, J. Bio. Chem. 241, 5213-5219.
18. Dyer, J.R., and Greenwood, C.E. (1991) Neural 22-Carbon Fatty Acids in the Weanling Rat Respond Rapidly and Specifically to a Range of Dietary Linoleic to α-Linolenic Fatty Acid Ratios, J. Neurochem. 56, 1921-1931.
19. Chautan, M., Calaf, R., Leonardi, J., Charbonnier, M., Andre, M., Portugal, H., Pauli, A.M., Lafont, H., and Nalbone, G. (1990) Inverse Modifications of Heart and Liver Alpha Tocopherol Status by Various Dietary n-6/n-3 Polyunsaturated Fatty Acid Ratios, J. Lipid Res. 31, 2201-2208.
20. Huang, Y.S., Wainwright, P.E., Redden, P.R., Mills, D.E., Bulman-Fleming, B., and Horrobin, D.F. (1992) Effect of Maternal Dietary Fats with Variable n-3/n-6 ratios on Tissue Fatty Acid Composition in Suckling Mice, Lipids 27, 104-110.
21. Wainwright, P.E., Huang, Y.S., Bulman-Fleming, B., Dalby, D., Mills, D.E., Redden, P., and McCutcheon, D. (1992) The Effects of Dietary n-3/n-6 Ratio on Brain Development in the Mouse: A Dose Response Study with Long-Chain n-3 Fatty Acids, Lipids 27, 98-103.
22. Moore, S.A., Yoder, E., and Spector, A.A. (1990) Role of the Blood-Brain Barrier in the Formation of Long-Chain ω-3 and ω-6 Fatty Acids from Essential Fatty Acid Precursors, J. Neurochem. 55, 391-402.
23. Spector, R. (1988) Fatty Acid Transport Through the Blood-Brain Barrier, J. Neurochem. 50, 639-643.
24. Alberghina, M., Lupo, G., Anfuso, C.D., and Moro, F. (1993) Palmitate Transport Through the Blood-Retina and Blood-Brain Barrier of Rat Visual System During Aging, Neurosci. Lett. 150, 17-20.
25. Alberghina, M., Lupo, G., Anfuso, C.D., and Infarinato, S. (1994) Differential Transport of Docosahexaenoate and Palmitate Through the Blood-Retina and Blood-Brain Barrier of the Rat, Neurosci. Lett. 171, 133-136.
26. Guesnet, P., Pascal, G., and Durand, G. (1986) Dietary α-Linolenic-Acid Deficiency in the Rat I. Effects on the Reproduction and Postnatal Growth, Reprod. Nutr. Dev. 26, 969-986.
27. Tinoco, J., Williams, M.A., Hincenbergs, I., and Lyman, R.L. (1971) Evidence for Nonessentiality of Linolenic Acid in the Diet of the Rat, J. Nutr. 101, 937-946.
28. Bourre, J.M., Piciotti, M., Dumont, O., Pascal, G., and Durand, G. (1990) Dietary Linoleic Acid and Polyunsaturated Fatty Acids in Rat Brain and Other Organs. Minimal Requirements of Linoleic Acid, Lipids 25, 465-472.
29. Bligh, E.G., and Dyer, W.J. (1959) A Rapid Method of Total Lipid Extraction and Purification, Can. J. Biochem. Physiol. 37, 911-917.
30. Holman, R.T. (1960) The Ratio of Trienoic:Tetraenoic Acids in Tissue Lipids as a Measure of Essential Fatty Acid Requirement, J. Nutr. 70, 405-410.
31. Ward, G., Woods, J., Reyzer, M., Salem, Jr., N. (1996) Artificial Rearing of Infant Rats on Milk Formula Deficient in n-3 Essential Fatty Acids: A Rapid Method for the Production of Experimental n-3 Deficiency, Lipids 31, 71-77.
32. Bourre, J.M.E., Dumont, O.S., Piciotti, M.J., Pascal, G.A., and Durand, G.A. (1992) Dietary Alpha Linolenic Acid Deficiency in Adult Rats for 7 Months Does Not Alter Brain Docosahexaenoic Acid Content in Contrast to Liver Heart and Testes, Biochim. Biophys. Acta 1124, 119-122.
33. Arbuckle, L.D., MacKinnon, M.J., and Innis, S.M. (1994) Formula 18:2(n-6) and 18:3(n-3) Content and Ratio Influence Long-Chain Polyunsaturated Fatty Acids in the Developing Piglet Liver and Central Nervous System, J. Nutr. 124, 289-298.
34. Anderson, G.J. (1994) Developmental Sensitivity of the Brain to Dietary n-3 Fatty Acids, J. Lipid Res. 35, 105-111.
35. Sheaff, R.C., Su, H.-M., Keswick, L.A., and Brenna, J.T. (1995) Conversion of α-Linolenate to Docosahexaenoate Is Not Depressed by High Dietary Levels of Linoleate in Young Rats: Tracer Evidence Using High Precision Mass Spectrometry, J. Lipid Res. 36, 998-1008.
36. Ponder, D.L., Innis, S.M., Benson, J.D., and Siegman, J.S. (1992) Docosahexaenoic Acid Status of Term Infants Fed Breast Milk or Infant Formula Containing Soy Oil or Corn Oil, Pediatr. Res. 32, 683-688.
37. Neuringer, M. (1992) The Relationship of Fatty Acid Composition to Function in the Retina and Visual System, in Lipids, Learning, and the Brain: Fats in Infant Formulas (Report of the 103rd Ross Conference on Pediatric Research) pp. 134-163, Ross Laboratories, Columbus, Ohio.
38. Weisinger, H.S., Vingrys, A.J., and Sinclair, A.J. (1996) Effect of Dietary n-3 Deficiency on the Electroretinogram in the Guinea Pig, Ann. Nutr. Metab. 40, 91-98.
39. Woods, J., Ward, G., and Salem, N. (1996) Is Docosahexaenoic Acid Necessary in Infant Formula? Evaluation of High Linolenate Diets in the Neonatal Rat, Ped. Res., in press.
40. Hamosh, M. (1995) Enzymes in Human Milk, in Handbook of Milk Composition (Jensen, R.G., ed.) pp. 388-427, Academic Press, San Diego.
41. Bourre, J.M., Piciotti, M., and Dumont, O. (1990) Delta-6 Desaturase in Brain and Liver During Development and Aging, Lipids 25, 354-356.
42. Bourre, J.M., and Piciotti, M. (1992) Delta-6 Desaturation of α-Linolenic Acid in Brain and Liver During Development and Aging in the Mouse, Neuroscience Letters 141, 65-68.
43. Jensen, C.L., Chen, H., Fraley, J.K., Andreson, R.E., and Heird, W.C. (1996) Biochemical Effects of Dietary Linoleic-α-linolenic Acid Ratio in Term Infants, Lipids 31, 107-113.
44. Clark, K.J., Makrides, M., Neumann, M.A., and Gibson, R.A. (1992) Determination of the Optimal Ratio of Linoleic Acid and α-Linolenic Acid in Infant Formulas, J. Pediatr. 120, s151-s158.
45. Uauy, R., Treen, M., and Hoffman, D.R. (1989) Essential Fatty Acid Metabolism and Requirements During Development, Semin. in Perina. 13, 118-130.
46. Van-Aerde, J.E., and Clandinin, M.T. (1993) Controversy in Fatty Acid Balance, Can. J. Physiol. Pharmacol. 71, 707-712.