Effects of MCC-135 on Ca2+ uptake by sarcoplasmic reticulum and myofilament sensitivity to Ca2+ in isolated ventricular muscles of rats with diabetic cardiomyopathy

Molecular and Cellular Biochemistry

Volumn 249, Issue 1-2, 2003, Pages 45-51

  Satoh, Naoya ^a   Kitada, Yoshimi ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Ca2+ sensitivity; Diabetic cardiomyopathy; Lusitropy; MCC 135; Sarcoplasmic reticulum; Skinned fibers

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BENZENESULFONIC ACID DERIVATIVE; CALCIUM ION; CALDARET; MCC 135; PHOSPHOLAMBAN; SAPONIN; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CARDIOMYOPATHY; CELL FUNCTION; CONTROLLED STUDY; DIASTOLE; DRUG MECHANISM; HEART PAPILLARY MUSCLE; HEART VENTRICLE; INOTROPISM; ISOLATION PROCEDURE; MALE; MODULATION; MUSCLE FORCE; MYOFILAMENT; NONHUMAN; RAT; RAT STRAIN; SARCOPLASMIC RETICULUM; SENSITIVITY ANALYSIS; SKINNED MUSCLE FIBER; WESTERN BLOTTING;

ANIMALS; BENZENESULFONATES; CALCIUM; CARDIOMYOPATHIES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC ANGIOPATHIES; MALE; MICROFILAMENTS; PAPILLARY MUSCLES; PIPERAZINES; RATS; RATS, WISTAR; SAPONINS; SARCOPLASMIC RETICULUM;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0042475577     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024705800110     Document Type: Article

References (34)

1. 2+ handling in streptozotocin-induced diabetic rat myocardium. Am J Physiol 277: H2185-H2194, 1999
2. Katz AM: In: Heart Failure. Lippincott Williams & Wilkins, Philadelphia, 2000, pp 47-51.
3. 2+-pump ATPase of the diabetic rat heart by lipid-lowering interventions. Mol Cell Biochem 132: 69-80, 1994
4. Hasenfuss G, Meyer M, Schillinger W, Preuss M, Pieske B, Just H: Calcium handling proteins in the failing human heart. Basic Res Cardiol 92(suppl 1): 87-93, 1997
5. 2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy. J Mol Med 74: 321-332, 1996
6. Veksler VI, Murat I, Ventura-Clapier R: Creatine kinase and mechanical and mitochondrial functions in hereditary and diabetic cardiomyopathies. Can J Physiol Pharmacol 69: 852-858, 1991
7. Malhotra A, Reich D, Reich D, Nakouzi A, Sanghi V, Geenen DL, Buttrick PM: Experimental diabetes is associated with functional activation of protein kinase C epsilon and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor. Circ Res 81: 1027-1033, 1997
8. 2+ sensitivity of skinned cardiac muscle contractility coincident with troponin T-band shifts in the diabetic rat. Circ Res 76: 600-606, 1995
9. 2+ transport in streptozotocin-induced diabetic cardiomyopathy in rats. Am J Physiol 253: E202-E207, 1987
10. 2+ currents in ventricular myocytes from rats with chronic diabetes. Am J Physiol 269: H1288-H1296, 1995
11. Bouchard RA, Bose D: Influence of experimental diabetes on sarcoplasmic reticulum function in rat ventricular muscle. Am J Physiol 260: H341-H354, 1991
12. Dhalla NS, Liu X, Panagia V, Takeda N: Subcellular remodeling and heart dysfunction in chronic diabetes. Cardiovasc Res 40: 239-247, 1998
13. Ren J, Davidoff AJ: Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes. Am J Physiol 272: H148-H158, 1997
14. Lagadic-Gossmann D, Feuvray D: Decreased sensitivity of contraction to changes of intracellular pH in papillary muscle from diabetic rat hearts. J Physiol 422: 481-497, 1990
15. Puley G, Dawood F, Wen W, Hou D, Backx P, Aitken K, Liu P: The effect of a novel cardioprotector AAA-135 on the morphology and function in a viral model of cardiomyopathy. Circulation 98: I-105, 1998
16. 2+-handling modulator MCC-135 improves left ventricular function and reduces mortality in cardiomyopathic hamsters. J Card Fail 5: 57, 1999
17. Satoh N, Sato T, Shimada M, Yamada K, Kitada Y: Lusitropic effect of MCC-135 is associated with improvement of sarcoplasmic reticulum function in ventricular muscles of rats with diabetic cardiomyopathy. J Pharmacol Exp Ther 298: 1161-1166, 2001
18. Hoit BD, Castro C, Bultron G, Knight S, Matlib MA: Non-invasive evaluation of cardiac dysfunction by echocardiography in streptozotocin-induced diabetic rats. J Card Fail 5: 324-333, 1999
19. Yamamoto J, Nakai M: Effects of moderate diabetes on cardiac performance in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension 11: 344-351, 1988
20. Satoh N, Suter TM, Liao R, Colucci WS: Chronic alpha-adrenergic receptor stimulation modulates the contractile phenotype of cardiac myocytes in vitro. Circulation 102: 2249-2254, 2000
21. 2+ sensitivity of the contractile system by MCI-154, a novel cardiotonic agent, in chemically skinned fibers from the guinea pig papillary muscles. J Pharmacol Exp Ther 243: 633-638, 1987
22. Endo M, Lino M: Specific perforation of muscle cell membranes with preserved SR functions by saponin treatment. J Muscle Res Cell Motil 1: 89-100, 1980
23. Ganguly PK, Pierce GN, Dhalla KS, Dhalla NS: Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy. Am J Physiol 244: E528-E535, 1983
24. Zhong Y, Ahmed S, Grupp IL, Matlib MA: Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts. Am J Physiol Heart Circ Physiol 281: H1137-H1147, 2001
25. Zarain-Herzberg A, Yano K, Elimban V, Dhalla NS: Cardiac sarcoplasmic reticulum Ca(2+)-ATPase expression in streptozotocin-induced diabetic rat heart. Biochem Biophys Res Commun 203: 113-120, 1994
26. Yao Q, Chen LT, Li J, Brungardt K, Squier TC, Bigelow DJ: Oligomeric interactions between phospholamban molecules regulate Ca-ATPase activity in functionally reconstituted membranes. Biochemistry 40: 6406-6413, 2001
27. 2+ Channel mRNA in streptozotocin-induced diabetic rat heart. J Mol Cell Cardiol 32: 655-664, 2000
28. Davia K, Hajjar RJ, Terracciano CM, Kent NS, Ranu HK, O'Gara P, Rosenzweig A, Harding SE: Functional alterations in adult rat myocytes after overexpression of phospholamban with use of adenovirus. Physiol Genomics 1: 41-50, 1999
29. 2+-cycling proteins may underlie sarcoplasmic reticulum dysfunction in the diabetic heart. Diabetes 50: 2133-2138, 2001
30. Schwinger RH, Munch G, Bolck B, Karczewski P, Krause EG, Erdmann E: Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation. J Mol Cell Cardiol 31: 479-491, 1999
31. 2+. Curr Topics Pharmacol 5: 109-117, 2000
32. 2+] and pH in rat skinned cardiac myocytes. Am J Physiol 269: H1656-H1663, 1995
33. Liu X, Takeda N, Dhalla NS: Troponin I phosphorylation in heart homogenate from diabetic rat. Biochim Biophys Acta 1316: 78-84, 1996
34. Luo W, Grupp IL, Harrer J, Ponniah S, Grupp G, Duffy JJ, Doetschman T, Kranias EG: Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res 75: 401-409, 1994