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Volumn 85, Issue 2-5, 2003, Pages 349-355

Androgen deficiency in the aging male: Benefits and risks of androgen supplementation

Author keywords

Aging; Bone; Muscle; Prostate disease; Psyche; Testosterone

Indexed keywords

ANDROGEN; ATAMESTANE; FINASTERIDE; TESTOSTERONE;

EID: 0042388613     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(03)00206-1     Document Type: Conference Paper
Times cited : (48)

References (64)
  • 2
    • 0025884064 scopus 로고
    • Age, disease, and changing sex hormone levels in middle-aged men: Results of the Massachusetts Male Aging Study
    • Gray A., Feldman H.A., McKinlay J.B., Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J. Clin. Endocrinol. Metab. 73:1991;1016-1025.
    • (1991) J. Clin. Endocrinol. Metab. , vol.73 , pp. 1016-1025
    • Gray, A.1    Feldman, H.A.2    McKinlay, J.B.3    Longcope, C.4
  • 3
    • 0029968711 scopus 로고    scopus 로고
    • Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males
    • Vermeulen A., Kaufman J.M., Giagulli V.A. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J. Clin. Endocrinol. Metab. 81:1996;1821-1826.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 1821-1826
    • Vermeulen, A.1    Kaufman, J.M.2    Giagulli, V.A.3
  • 4
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging
    • Harman S.M., Metter E.J., Tobin J.D., Pearson J., Blackman M.R. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J. Clin. Endocrinol. Metab. 86:2001;724-731.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 7
    • 0027965382 scopus 로고
    • Progressive loss of bone in the femoral neck in elderly people: Longitudinal findings from the Dubbo osteoporosis epidemiology study
    • Jones G., Nguyen T., Sambrook P., Kelly P.J., Eisman J.A. Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ. 309:1994;691-695.
    • (1994) BMJ , vol.309 , pp. 691-695
    • Jones, G.1    Nguyen, T.2    Sambrook, P.3    Kelly, P.J.4    Eisman, J.A.5
  • 12
    • 0026742650 scopus 로고
    • Effects of testosterone supplementation in the aging male
    • Tenover J.S. Effects of testosterone supplementation in the aging male. J. Clin. Endocrinol. Metab. 75:1992;1092-1098.
    • (1992) J. Clin. Endocrinol. Metab. , vol.75 , pp. 1092-1098
    • Tenover, J.S.1
  • 17
    • 0028787009 scopus 로고
    • Muscle protein turnover: methodological issues and the effect of aging
    • K.S. Nair, Muscle protein turnover: methodological issues and the effect of aging, J. Gerontol. A Biol. Sci. Med. Sci. 50 (1995) 107-112.
    • (1995) J. Gerontol. A Biol. Sci. Med. Sci. , vol.50 , pp. 107-112
    • Nair, K.S.1
  • 21
    • 0032812020 scopus 로고    scopus 로고
    • Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men
    • Clague J.E., Wu F.C., Horan M.A. Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men. Int. J. Androl. 22:1999;261-265.
    • (1999) Int. J. Androl. , vol.22 , pp. 261-265
    • Clague, J.E.1    Wu, F.C.2    Horan, M.A.3
  • 22
    • 0028293411 scopus 로고
    • Testosterone influences spatial cognition in older men
    • Janowsky J.S., Oviatt S.K., Orwoll E.S. Testosterone influences spatial cognition in older men. Behav. Neurosci. 108:1994;325-332.
    • (1994) Behav. Neurosci. , vol.108 , pp. 325-332
    • Janowsky, J.S.1    Oviatt, S.K.2    Orwoll, E.S.3
  • 25
    • 0031879102 scopus 로고    scopus 로고
    • The relationship between depressive symptoms and male erectile dysfunction: Cross-sectional results from the Massachusetts Male Aging Study
    • Araujo A.B., Durante R., Feldman H.A., Goldstein I., McKinlay J.B. The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psychosom. Med. 60:1998;458-465.
    • (1998) Psychosom. Med. , vol.60 , pp. 458-465
    • Araujo, A.B.1    Durante, R.2    Feldman, H.A.3    Goldstein, I.4    McKinlay, J.B.5
  • 26
    • 0042909139 scopus 로고    scopus 로고
    • Gynecomastia
    • J.A.H. Wass, Shalet S.M. (Eds.), Oxford University press, Oxford, UK
    • L.J.G. Gooren, Gynecomastia, in: J.A.H. Wass, Shalet S.M. (Eds.), Oxford Textbook of Endocrinology and Diabetes, Oxford University press, Oxford, UK, 2002.
    • (2002) Oxford Textbook of Endocrinology and Diabetes
    • Gooren, L.J.G.1
  • 27
    • 0026458356 scopus 로고
    • Lower endogenous androgen levels and dyslipidemia in men with non-insulin-dependent diabetes mellitus
    • Barrett-Connor E. Lower endogenous androgen levels and dyslipidemia in men with non-insulin-dependent diabetes mellitus. Ann. Intern. Med. 117:1992;807-811.
    • (1992) Ann. Intern. Med. , vol.117 , pp. 807-811
    • Barrett-Connor, E.1
  • 28
    • 0023067143 scopus 로고
    • Low serum testosterone and myocardial infarction in geriatric male inpatients
    • Swartz C.M., Young M.A. Low serum testosterone and myocardial infarction in geriatric male inpatients. J. Am. Geriatr. Soc. 35:1987;39-44.
    • (1987) J. Am. Geriatr. Soc. , vol.35 , pp. 39-44
    • Swartz, C.M.1    Young, M.A.2
  • 29
    • 0002111584 scopus 로고    scopus 로고
    • Androgens and cardiovascular disease in men and women
    • Vermeulen A., Kaufman J.M. Androgens and cardiovascular disease in men and women. Aging Male. 1:1998;35-50.
    • (1998) Aging Male , vol.1 , pp. 35-50
    • Vermeulen, A.1    Kaufman, J.M.2
  • 31
    • 0028075376 scopus 로고
    • Relation of components of insulin resistance syndrome to coronary disease risk
    • Despres J.P., Marette A. Relation of components of insulin resistance syndrome to coronary disease risk. Curr. Opin. Lipidol. 5:1994;274-289.
    • (1994) Curr. Opin. Lipidol. , vol.5 , pp. 274-289
    • Despres, J.P.1    Marette, A.2
  • 32
    • 0027487857 scopus 로고
    • Regional obesity and NIDDM
    • Bjorntorp P. Regional obesity and NIDDM. Adv. Exp. Med. Biol. 334:1993;279-285.
    • (1993) Adv. Exp. Med. Biol. , vol.334 , pp. 279-285
    • Bjorntorp, P.1
  • 34
    • 0025083282 scopus 로고
    • Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels
    • Seidell J.C., Bjorntorp P., Sjostrom L., Kvist H., Sannerstedt R. Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism. 39:1990;897-901.
    • (1990) Metabolism , vol.39 , pp. 897-901
    • Seidell, J.C.1    Bjorntorp, P.2    Sjostrom, L.3    Kvist, H.4    Sannerstedt, R.5
  • 35
    • 0030830178 scopus 로고    scopus 로고
    • Relationships between endogenous steroid hormone, sex hormone-binding globulin and lipoprotein levels in men: Contribution of visceral obesity, insulin levels and other metabolic variables
    • Tchernof A., Labrie F., Belanger A., Prud'homme D., Bouchard C., Tremblay A., Nadeau A., Despres J.P. Relationships between endogenous steroid hormone, sex hormone-binding globulin and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variables. Atherosclerosis. 133:1997;235-244.
    • (1997) Atherosclerosis , vol.133 , pp. 235-244
    • Tchernof, A.1    Labrie, F.2    Belanger, A.3    Prud'homme, D.4    Bouchard, C.5    Tremblay, A.6    Nadeau, A.7    Despres, J.P.8
  • 38
    • 0015921748 scopus 로고
    • Androgens and erythropoiesis
    • Shahidi N.T. Androgens and erythropoiesis. N. Engl. J. Med. 289:1973;72-80.
    • (1973) N. Engl. J. Med. , vol.289 , pp. 72-80
    • Shahidi, N.T.1
  • 39
    • 0030694397 scopus 로고    scopus 로고
    • Outcomes of long-term testosterone replacement in older hypogonadal males: A retrospective analysis
    • Hajjar R.R., Kaiser F.E., Morley J.E. Outcomes of long-term testosterone replacement in older hypogonadal males: a retrospective analysis. J. Clin. Endocrinol. Metab. 82:1997;3793-3796.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 3793-3796
    • Hajjar, R.R.1    Kaiser, F.E.2    Morley, J.E.3
  • 40
    • 0031589468 scopus 로고    scopus 로고
    • Effects of various modes of androgen substitution therapy on erythropoiesis
    • Jockenhovel F., Vogel E., Reinhardt W., Reinwein D. Effects of various modes of androgen substitution therapy on erythropoiesis. Eur. J. Med. Res. 2:1997;293-298.
    • (1997) Eur. J. Med. Res. , vol.2 , pp. 293-298
    • Jockenhovel, F.1    Vogel, E.2    Reinhardt, W.3    Reinwein, D.4
  • 42
    • 0023880544 scopus 로고
    • Reversible reproductive dysfunction in men with obstructive sleep apnoea
    • Santamaria J.D., Prior J.C., Fleetham J.A. Reversible reproductive dysfunction in men with obstructive sleep apnoea. Clin. Endocrinol. (Oxford). 28:1988;461-470.
    • (1988) Clin. Endocrinol. (Oxford) , vol.28 , pp. 461-470
    • Santamaria, J.D.1    Prior, J.C.2    Fleetham, J.A.3
  • 45
    • 0026492741 scopus 로고
    • Androgen blockade does not affect sleep-disordered breathing or chemosensitivity in men with obstructive sleep apnea
    • Stewart D.A., Grunstein R.R., Berthon-Jones M., Handelsman D.J., Sullivan C.E. Androgen blockade does not affect sleep-disordered breathing or chemosensitivity in men with obstructive sleep apnea. Am. Rev. Respir. Dis. 146:1992;1389-1393.
    • (1992) Am. Rev. Respir. Dis. , vol.146 , pp. 1389-1393
    • Stewart, D.A.1    Grunstein, R.R.2    Berthon-Jones, M.3    Handelsman, D.J.4    Sullivan, C.E.5
  • 46
    • 0033304531 scopus 로고    scopus 로고
    • Hormonal signaling in prostatic hyperplasia and neoplasia
    • Marcelli M., Cunningham G.R. Hormonal signaling in prostatic hyperplasia and neoplasia. J. Clin. Endocrinol. Metab. 84:1999;3463-3468.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3463-3468
    • Marcelli, M.1    Cunningham, G.R.2
  • 47
    • 0027937517 scopus 로고
    • High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: An autopsy study of 249 cases
    • Sakr W.A., Grignon D.J., Crissman J.D., Heilbrun L.K., Cassin B.J., Pontes J.J., Haas G.P. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases. In Vivo. 8:1994;439-443.
    • (1994) In Vivo , vol.8 , pp. 439-443
    • Sakr, W.A.1    Grignon, D.J.2    Crissman, J.D.3    Heilbrun, L.K.4    Cassin, B.J.5    Pontes, J.J.6    Haas, G.P.7
  • 50
    • 0028861415 scopus 로고
    • A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia
    • Gann P.H., Hennekens C.H., Longcope C., Verhoek-Oftedahl W., Grodstein F., Stampfer M.J. A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia. Prostate. 26:1995;40-49.
    • (1995) Prostate , vol.26 , pp. 40-49
    • Gann, P.H.1    Hennekens, C.H.2    Longcope, C.3    Verhoek-Oftedahl, W.4    Grodstein, F.5    Stampfer, M.J.6
  • 51
    • 0027328388 scopus 로고
    • Effect of aging on endogenous level of 5 alpha-dihydrotestosterone, testosterone, estradiol, and estrone in epithelium and stroma of normal and hyperplastic human prostate
    • Krieg M., Nass R., Tunn S. Effect of aging on endogenous level of 5 alpha-dihydrotestosterone, testosterone, estradiol, and estrone in epithelium and stroma of normal and hyperplastic human prostate. J. Clin. Endocrinol. Metab. 77:1993;375-381.
    • (1993) J. Clin. Endocrinol. Metab. , vol.77 , pp. 375-381
    • Krieg, M.1    Nass, R.2    Tunn, S.3
  • 52
    • 0032510686 scopus 로고    scopus 로고
    • From estrogen to androgen receptor: A new pathway for sex hormones in prostate
    • Yeh S., Miyamoto H., Shima H., Chang C. From estrogen to androgen receptor: a new pathway for sex hormones in prostate. Proc. Natl. Acad. Sci. U.S.A. 95:1998;5527-5532.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 5527-5532
    • Yeh, S.1    Miyamoto, H.2    Shima, H.3    Chang, C.4
  • 54
    • 0029963510 scopus 로고    scopus 로고
    • Estrogen reduction by aromatase inhibition for benign prostatic hyperplasia: Results of a double-blind, placebo-controlled, randomized clinical trial using two doses of the aromatase-inhibitor atamestane. Atamestane Study Group
    • Radlmaier A., Eickenberg H.U., Fletcher M.S., Fourcade R.O., Reis Santos J.M., van Aubel O.G., Bono A.V. Estrogen reduction by aromatase inhibition for benign prostatic hyperplasia: results of a double-blind, placebo-controlled, randomized clinical trial using two doses of the aromatase-inhibitor atamestane. Atamestane Study Group. Prostate. 29:1996;199-208.
    • (1996) Prostate , vol.29 , pp. 199-208
    • Radlmaier, A.1    Eickenberg, H.U.2    Fletcher, M.S.3    Fourcade, R.O.4    Reis Santos, J.M.5    Van Aubel, O.G.6    Bono, A.V.7
  • 56
    • 0033754872 scopus 로고    scopus 로고
    • Prostate cancer: How much do we know and how do we know it?
    • Kleinman K.J.P., McKinlay J.B. Prostate cancer: how much do we know and how do we know it? Aging Male. 3:2000;115-123.
    • (2000) Aging Male , vol.3 , pp. 115-123
    • Kleinman, K.J.P.1    McKinlay, J.B.2
  • 58
    • 0028358995 scopus 로고
    • Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age-matched normal controls
    • Behre H.M., Bohmeyer J., Nieschlag E. Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age-matched normal controls. Clin. Endocrinol. (Oxford). 40:1994;341-349.
    • (1994) Clin. Endocrinol. (Oxford) , vol.40 , pp. 341-349
    • Behre, H.M.1    Bohmeyer, J.2    Nieschlag, E.3
  • 59
    • 0024992178 scopus 로고
    • Volume change of the prostate and seminal vesicles in male hypogonadism after androgen replacement therapy
    • Sasagawa I., Nakada T., Kazama T., Satomi S., Terada T., Katayama T. Volume change of the prostate and seminal vesicles in male hypogonadism after androgen replacement therapy. Int. Urol. Nephrol. 22:1990;279-284.
    • (1990) Int. Urol. Nephrol. , vol.22 , pp. 279-284
    • Sasagawa, I.1    Nakada, T.2    Kazama, T.3    Satomi, S.4    Terada, T.5    Katayama, T.6
  • 60
    • 0027514228 scopus 로고
    • Prostate-specific antigen and prostate gland size in men receiving exogenous testosterone for male contraception
    • Wallace E.M., Pye S.D., Wild S.R., Wu F.C. Prostate-specific antigen and prostate gland size in men receiving exogenous testosterone for male contraception. Int. J. Androl. 16:1993;35-40.
    • (1993) Int. J. Androl. , vol.16 , pp. 35-40
    • Wallace, E.M.1    Pye, S.D.2    Wild, S.R.3    Wu, F.C.4
  • 61
    • 0027425903 scopus 로고
    • Effect of long-term oral testosterone undecanoate treatment on prostate volume and serum prostate-specific antigen concentration in eugonadal middle-aged men
    • Holmang S., Marin P., Lindstedt G., Hedelin H. Effect of long-term oral testosterone undecanoate treatment on prostate volume and serum prostate-specific antigen concentration in eugonadal middle-aged men. Prostate. 23:1993;99-106.
    • (1993) Prostate , vol.23 , pp. 99-106
    • Holmang, S.1    Marin, P.2    Lindstedt, G.3    Hedelin, H.4
  • 62
    • 0027299036 scopus 로고
    • 7 Alpha-methyl-nortestosterone (MENT): The optimal androgen for male contraception
    • Sundaram K., Kumar N., Bardin C.W. 7 alpha-methyl-nortestosterone (MENT): the optimal androgen for male contraception. Ann. Med. 25:1993;199-205.
    • (1993) Ann. Med. , vol.25 , pp. 199-205
    • Sundaram, K.1    Kumar, N.2    Bardin, C.W.3
  • 63
    • 0013540319 scopus 로고    scopus 로고
    • Development of criteria to monitor the occurrence of prostate cancer in testosterone clinical trials
    • S. Bhasin, H.L. Gabelnick, R.S. Swerdloff, C. Wang (Eds.), Wiley, New York
    • P.J. Snyder, Development of criteria to monitor the occurrence of prostate cancer in testosterone clinical trials, in: S. Bhasin, H.L. Gabelnick, R.S. Swerdloff, C. Wang (Eds.), Pharmacology, Biology, and Clinical Applications of Androgens, Wiley, New York, 1996, pp. 143-150.
    • (1996) Pharmacology, Biology, and Clinical Applications of Androgens , pp. 143-150
    • Snyder, P.J.1
  • 64
    • 0032844250 scopus 로고    scopus 로고
    • Andropause, androgen therapy and prostate safety
    • Morales A. Andropause, androgen therapy and prostate safety. Aging Male. 2:1999;81-87.
    • (1999) Aging Male , vol.2 , pp. 81-87
    • Morales, A.1


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