Cytokine release and adhesion molecule expression by stimulated human bronchial epithelial cells are downregulated by salmeterol

Respiratory Medicine

Volumn 97, Issue 9, 2003, Pages 1052-1060

  Sabatini, F ^a   Silvestri, M ^a   Sale, R ^a   Serpero, L ^a   Di Blasi, P ^b   Rossi, Giovanni A ^a  

^a G GASLINI INSTITUTE   (Italy)

^b GSK   (Italy)

Author keywords

Adhesion molecules; Asthma; Cytokine release; Epithelial cells; 2 agonists

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHEMOKINE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; INTERLEUKIN 8; RANTES; SALMETEROL; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CELL ISOLATION; CELL STIMULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; EFFECTOR CELL; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; UPREGULATION;

EID: 0042381855     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0954-6111(03)00137-9     Document Type: Article

References (48)

1. Robbins RA, Rennard SI. Biology of airway epithelial cells. In: Crystal RG, West JB, Barnes PJ, Weibel ER, editors. The lung: Scientific Foundations. Philadelphia: Lippincott-Raven Publishers Ltd.; 1997.
2. Raeburn D, Webber SE. Proinflammatory potential of the airway epithelium in bronchial asthma. Eur Respir J 1994;7: 2226-33.
3. Guidelines for the diagnosis, management of asthma: expert panel report 2. National Institutes of Health, National Heart, Lung and Blood Institutes. Publication Number 1997; 97(4051):1-4.
4. Barnes BJ. Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med 1995;152:828-60.
5. Nelson HS. β-adrenergic bronchodilators. N Engl J Med 1995;333:499-506.
6. Barnes J. Effects of beta-agonists on inflammatory cells. J Allergy Clin Immunol 1999;104:S10-7.
7. Yukawa T, Ukena D, Chanez P, Dent G, Chung KF, Barnes PJ. Beta-adrenergic receptors on eosinophils: binding and functional studies. Am Rev Respir Dis 1990;141:1446-52.
8. Busse WW, Sosman JM. Isoproterenol inhibition of isolated neutrophil function. J Allergy Clin Immunol 1984;73: 404-10.
9. Oddera S, Silvestri M, Scarso L, Testi R, Rossi GA. Salmeterol Inhibits the allergen-induced mononuclear cell proliferation and downregulates GM-CSF release and HLA-DR expression by monocytes. Pulm Pharmacol Ther 1997;10: 43-9.
10. 2-adrenoreceptor stimulation but not in cell apoptosis. J Asthma 2000;37:281-90.
11. Devalia JL, Sapsford RJ, Rusznak C, Toumbis MJ, Davies RJ. The effects of salmeterol and salbutamol on ciliary beat frequency of cultured human bronchial epithelial cells, in vitro. Pulm Pharmacol Ther 1992;5:257-63.
12. Yang B, Schlosser RJ, McCaffrey TV. Dual signal transduction mechanisms modulate ciliary beat frequency in upper airway epithelium. Am J Physiol 1996;270:745-51.
13. Nishimura K, Tamaoki J, Aoshiba K, Isono K, Nagai A. Effects of salbutamol on proliferation of human bronchial epithelial cells: role of MAP kinase. Nihon Kokyuki Gakkai Zasshi 1998;36:1428-32.
14. Hastie AT, Everts KB, Shaver JR, et al. Beta 2-agoinist-elevated stress response in human bronchial epithelial cells in vivo and in vitro. Lung 1997;175:287-98.
15. Romberger DJ, Heires P, Rennard SI, Wyatt TA. Beta-adrenergic modulation of monocyte adhesion to airway epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol 2000;278:139-47.
16. Oddera S, Silvestri M, Lantero S, Sacco O, Rossi GA. Downregulation of the expression of intercellular adhesion molecule (ICAM)-1 on bronchial epithelial cells by a beta2-adrenoceptor agonist: fenoterol. J Asthma 1998;35(5): 401-8.
17. Gormand F, Cheria-Sammari S, Aloui R, et al. Granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin 8(IL-8) production by human bronchial epithelial cells (HBEC) in asthmatics and controls lack of in vitro effect of salbutamol compared to sodium nedocromil. Pulm Pharmacol Ther 1995;8:107-13.
18. Koyama S, Sato E, Masubuchi T, et al. Procaterol inhibits IL-1 beta and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J 1999;14:767-75.
19. Korn SH, Jerre A, Brettsand R. Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by stimulated human bronchial epithelial cells. Eur Respir J 2001;17: 1070-7.
20. Lipworth B, Grove A. Evaluation of partial β2-receptor agonist activity. Br J Clin Pharmacol 1997;43:9-14.
21. Rossi GA, Sacco O, Balbi B, et al. Human ciliated bronchial epithelial cells: expression of the HLA-DR antigens and of the HLA-DR alpha gene, modulation of the HLA-DR antigens by gamma interferon and antigen presenting function in the mixed leucocyte reaction. Am J Respir Cell Mol 1990;3: 431-40.
22. Sabatini F, Silvestri M, Scarso L, Brazzola G. Rossi GA: prolonged antiinflammatory activity of budesonide on activated human airway epithelial cells. J Asthma 2002;39: 11-20.
23. Striz I, Mio T, Adachi Y, et al. IL-4 induces ICAM-1 expression in human bronchial epithelial cells. Am J Physiol 1999;227: 58-64.
24. Fujisawa T, Kato Y, Atsuta J, et al. Chemokine production by the BEAS-2B human bronchial epithelial cells: differential regulation of eotaxin, IL-8, and RANTES by TH2- and TH1-derived cytokines. J Allergy Clin Immunol 2000;105: 126-33.
25. Montefort S, Holgate ST. Adhesion molecules and their role in inflammation. Respir Med 1991;85:91-9.
26. Montefort S, Roche WR, Howarth PH, et al. Intracellular adhesion molecule-1 (ICAM -1) and endothelial leukocyte adhesion molecule-1 (ELAM -1) expression in the bronchial mucosa of normal and asthmatic subjects. Eur Respir J 1992; 90:1379-85.
27. Tosi MF, Stark JM, Smith CW, Hamedani A, Gruenert DC, Infeld MD. Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines: effects on neutrophil epithelial cells adhesion. Am J Respir Cell Mol Biol 1992;7:214-21.
28. Tessier PA, Cattaruzzi P, McColl SR. Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 gene expression. Arthritis Rheum 1996;39:226-34.
29. Atsuta J, Plitt J, Bochner BS, Schleimer RP. Inhibition of VCAM-1 expression in humanbronchial epithelial cells by glucocorticoids. Am J Respir Cell Mol Biol 1999;20: 643-50.
30. Cromwell O, Hamid Q, Corrigan CJ, et al. Expression and generation of interleukin-8, IL-6 and granulocyte/macrophage colony stimulating factor by bronchial epithelial cells and enhancement by IL-1β and tumour necrosis factor-α. Immunology 1992;77:330-7.
31. Lantero S, Sacco O, Scaja C, Rossi GA. Stimulation of blood mononuclear cells of atopic children with the relevant allergen induces the release of eosinophil chemotaxins such as IL-3 , IL-5 and GM-CSF. J Asthma 1997;34: 141-52.
32. Schall T. Biology of the RANTES/SIS cytokine family. Biology 1991;3:165-83.
33. Kameyoshi Y, Dorschner A, Mallet AL, Christophers E, Schroder J-M. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 1992;176:587-92.
34. +-channels in trachealis muscle. Br J Pharmacol 1993;109:1140-8.
35. Johnson M. The β-adrenoceptor. J Respir Cril Care Med 1998;158:8146-53.
36. 2-agonists prevent Thl development by selective inhibition of interleukin 12. J Clin Invest 1997;100:1513-9.
37. Standiford TJ, Kunkel SL, Rolfe MW, Evanoll HL, Allen RM, Strieter RM. Regulation of human alveolar macrophage- and blood monocyte-derived interleukin-8 by prostaglandin E2 and dexamethasone. Am J Respir Cell Mol Biol 1992;6: 75-81.
38. Silvestri M, Fregonese L, Sabatini F, Dasic G, Rossi GA. Downregulation of fibroblast functions by fluticasone and salmeterol: inhibition of cell proliferation and adhesion molecule ICAM-1 and CD44 expression. Eur Respir J 2001;18: 139-45.
39. Momose T, Okubo Y, Horie S, Suzuki J, Isobe M, Sekiguchi M. Effects of intracellular cyclic AMP modulators on human eosinophils survival, degranulation and CD 11 expression. Int Arch Allergy Immunol 1998;117:138-45.
40. Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R. Association between genetic polymorphism of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997;100: 3184-8.
41. 2-adrenoceptor polymorphisms: are they clinically important? Thorax 1996;51:351-3.
42. Mary D, Aussel C, Ferrua B, Fehlmann M. Regulation of interleukin-2 synthesis by cAMP in human T-cells. J Immunol 1987;139:1179-84.
43. McGraw DW, Liggett SB. Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitisation of beta2-adrenergic receptor. J Biol Chem 1997;272:7338-44.
44. Kelsen SG, Anakwe OO, Aksoy MO, et al. Chronic effects of catecholamines on beta2-adrenoreceptor system in cultured human airway epithelial cells. Am J Physiol 1997;272: 916-24.
45. Pedersen B, Dahl R, Larsen BB, Venge P. The effects of salmeterol on the early and late-phase reaction to bronchial allergen and postchallenge variation in bronchial reactivity, blood eosinophils, serum eosinophil cationic protein and serum eosinophil protein X. Allergy 1993;48:377-82.
46. Taylor IK, O'Shaughnessy KM, Choudry NB, Adachi M, Palmer JBD, Fuller RW. A comparative study in atopic subject with asthma of effects of salmeterol and salbutamol on allergen-induced bronchoconstriction, increase in airway reactivity and increase in urinary leukotriene E4 excretion. J Allergy Clin Immunol. 1992;89:574-83.
47. 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma. J Allergy Clin Immunol 1992;90: 32-42.
48. Gardiner PV, Ward C, Booth H, Allison A, Hendrick DJ, Walter EH. Effects of eight weeks of treatment with salmeterol on bronchoalveolar lavage on inflammatory indices in asthmatics. Am J Respir Crit Care Med 1994;150: 1006-11.