Effects of low-level lead exposure on cell survival and neurite length in primary mesencephalic cultures

Neurotoxicology and Teratology

Volumn 25, Issue 5, 2003, Pages 555-559

  Schneider, J S ^a   Huang, F N ^a   Vemuri, M C ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Development; Lead; Neurons; Ventral mesencephalon

Indexed keywords

LEAD ACETATE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL CULTURE; ARTICLE; BRAIN DEVELOPMENT; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; FEMALE; MESENCEPHALON; NERVE CELL; NERVE FIBER GROWTH; NEURITE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0042334899     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(03)00018-7     Document Type: Article

References (32)

1. Bressler J., Kim K.A., Chakraborti T., Goldstein G. Molecular mechanisms of lead neurotoxicity. Neurochem. Res. 24:1999;595-600.
2. Bressler J.P., Goldstein G.W. Mechanisms of lead neurotoxicity. Biochem. Pharmacol. 41:1991;479-484.
3. Brockel B.J., Cory-Slechta D.A. Lead, attention and impulsive behavior: changes in a fixed ratio waiting-for-reward paradigm. Pharmacol. Biochem. Behav. 60:1998;545-552.
4. Brown L.L., Schneider J.S., Lidsky T.I. Sensory and cognitive functions of the basal ganglia. Curr. Opin. Neurobiol. 7:1997;157-163.
5. Brozoski T., Brown R.M., Rosvold H.E., Goldman P.S. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science. 2015:1979;929-931.
6. Centers for Disease Control and Prevention Preventing Lead Poisoning in Young Children: A Statement by the US Centers for Disease Control - October 1991. 1991;U.S. Department of Health and Human Services, Atlanta, GA.
7. Cline H.T., Witte S., Jones K.W. Low lead levels stunt neuronal growth in a reversible manner. Proc. Natl. Acad. Sci. 93:1996;9915-9920.
8. Crumpton T., Atkins D.S., Zawia N.H., Barone S. Jr. Lead exposure in pheochromocytoma (PC12) cells alters neural differentiation and Sp1 DNA-binding. Neurotoxicology. 22:2001;49-62.
9. Devoto P., Flore G., Ibba A., Fratta W., Pani L. Lead intoxication during intrauterine life and lactation but not during adulthood reduces nucleus accumbens dopamine release as studied by brain microdialysis. Toxicol. Lett. 121:2001;199-206.
10. Faust D., Brown J. Moderately elevated blood lead levels: effects on neuropsychologic functioning in children. Pediatrics. 80:1987;623-629.
11. Gardella C. Lead exposure in pregnancy: a review of the literature and argument for routine prenatal screening. Obstet. Gynecol. Surv. 56:2001;231-238.
12. Gomaa A., Hu H., Bellinger D., Schwartz J., Tsaih S.W., Gonzalez-Cossio T., Schnaas L., Peterson K., Aro A., Hernandez-Avila M. Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective study. Pediatrics. 110:2002;110-118.
13. Kern M., Audesirk G. Inorganic lead may inhibit neurite development in cultured rat hippocampal neurons through hyperphosphorylation. Toxicol. Appl. Pharmacol. 134:1995;111-123.
14. Kern M., Audesirk T., Audesirk G. Effects of inorganic lead on the differentiation and growth of cortical neurons in culture. Neurotoxicology. 14:1993;319-328.
15. Kohler K., Lilienthal H., Guenther E., Winneke G., Zrenner E. Persistent decrease of the dopamine-synthesizing enzyme tyrosine hydroxylase in the rhesus monkey retina after chronic lead exposure. Neurotoxicology. 18:1997;623-632.
16. Lange K.W., Robbins T.W., Marsden C.D., James M., Owen A.M., Paul G.M. L-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction. Psychopharmacology. 107:1992;394-404.
17. Lanphear B.P., Dietrich K., Auinger P., Cox C. Cognitive deficits associated with blood lead concentrations <10 μg/dl in US children and adolescents. Public Health Rep. 115:2000;521-529.
18. Lasley S.M., Green M.C., Gilbert M.E. Influence of exposure period on in vivo hippocampal glutamate and GABA release in rats chronically exposed to lead. Neurotoxicology. 20:1999;619-630.
19. Lidsky T.I., Schneider J.S. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain. 126:2003;5-19.
20. Lohmann C., Myhr K.L., Wong R.O. Transmitter-evoked local calcium release stabilizes developing neurites. Nature. 418:2002;177-181.
21. McIntosh M.J., Meredith P.A., Petty M.A., Reid J.L. Influence of lead exposure on catecholamine metabolism in discrete rat brain nuclei. Comp. Biochem. Physiol. 89:1988;211-213.
22. Nachsen D.A. Selectivity of the Ca binding site in the synaptosome Ca channels. Inhibition of Ca influx by multivalent metal cations. J. Gen. Physiol. 83:1984;941-967.
23. Nieoullon A. Dopamine in the regulation of cognition and attention. Prog. Neurobiol. 67:2002;53-83.
24. Schneider J.S., Kovelowski C.J. Chronic exposure to low doses of MPTP: I. Cognitive deficits in motor asymptomatic monkeys. Brain Res. 519:1990;122-128.
25. Schwartz J. Low-level lead exposure and children's IQ: a meta analysis and search for a threshold. Environ. Res. 65:1994;42-55.
26. Scortegagna M., Chikhale E., Hanbauer I. Effect of lead on cytoskeletal proteins expressed in E14 mesencephalic primary cultures. Neurochem. Int. 32:1998;353-359.
27. Scortegagna M., Hanbauer I. The effect of lead exposure and serum deprivation on mesencephalic primary cultures. Neurotoxicology. 18:1997;331-340.
28. Selvin-Testa A., Loidl C.F., Lopez E.M., Capani F., Lopez-Costa J.J., Pecci-Saavedra J. Prolonged lead exposure modifies astrocyte cytoskeletal proteins in the rat brain. Neurotoxicology. 16:1995;389-401.
29. Shulman L.M., Kala S.V., Jadhav A.L., Fox D.A. Alterations in the regulation of retinal dopamine content and release following lead exposure during development. Toxicologist. 30:1996;26.
30. Stokes L., Letz R., Gerr F., Kolczak M., McNeil F.E., Chettle D.R., Kaye W.E. Neurotoxicity in young adults 20 years after childhood exposure to lead: the Bunker Hill experience. Occup. Environ. Med. 55:1998;507-516.
31. Williams T.M., Ndifor A.M., Neary J.T., Reams-Brown R.R. Lead enhances NGF-Induced neurite outgrowth in PC12 cells by potentiating ERK/MAPK activation. Neurotoxicology. 21:2000;1081-1090.
32. Yokoyama K., Araki S. Assessment of slow axonal transport in lead-exposed rats. Environ. Res. 59:1992;440-446.