Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg2+ and 8-Oxo-dGMP, a tightly bound product

Biochemistry

Volumn 42, Issue 34, 2003, Pages 10140-10154

  Massiah, Michael A ^a   Saraswat, Vibhor ^a   Azurmendi, Hugo F ^a   Mildvan, Albert S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOLUTION STRUCTURE;

CONFORMATIONS; ENZYMES; NUCLEAR MAGNETIC RESONANCE;

COMPLEXATION;

8 OXODEOXYGUANOSINE MONOPHOSPHATE; ARGININE; ASPARAGINE; DEOXYGUANOSINE PHOSPHATE; INORGANIC PYROPHOSPHATASE; MAGNESIUM ION; PURINE; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENERGY; ENZYME BINDING; ESCHERICHIA COLI; HYDROGEN BOND; ION EXCHANGE; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

5'-GUANYLIC ACID; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ARGININE; BINDING SITES; DEOXYGUANINE NUCLEOTIDES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYROPHOSPHATASES; RECOMBINANT PROTEINS; SOLUTIONS; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 0042324507     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030105p     Document Type: Article

References (42)

1. Bessman, M. J., Frick, D. N., and O'Handley, S. F. (1996) J. Biol. Chem. 271, 25059-25062.
2. Weber, D. J., Bhatnagar, S. K., Bullions, L. C., Bessman, M. J., and Mildvan, A. S. (1992) J. Biol. Chem. 267, 16939-16942.
3. Mildvan, A. S., Weber, D. J., and Abeygunawardana, C. (1999) Adv. Enzymol. Relat. Areas Mol. Biol. 73, 183-207.
4. Frick, D. N., Weber, D. J., Gillespie, J. R., Bessman, M. J., and Mildvan, A. S. (1994) J. Biol. Chem. 269, 1794-1803.
5. Saraswat, V., Massiah, M. A., Lopez, G., Amzel, L. M., and Mildvan, A. S. (2002) Biochemistry 41, 15566-15577.
6. Lin, J., Abeygunawardana, C., Frick, D. N., Bessman, M. J., and Mildvan, A. S. (1997) Biochemistry 36, 1199-1211.
7. Harris, T. K., Wu, G., Massiah, M. A., and Mildvan, A. S. (2000) Biochemistry 39, 1655-1674.
8. Maki, H., and Sekiguchi, M. (1992) Nature 355, 273-275.
9. Shibutani, S., Takeshita, M., and Grollman, A. P. (1991) Nature 349, 431-434.
10. Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S., and Loeb, L. A. (1992) J. Biol. Chem. 267, 166-172.
11. Treffers, H. P., Spinelli, V., and Belser, N. O. (1954) Proc. Natl. Acad. Sci. U.S.A. 40, 1064-1071.
12. Yanofsky, C., Cox, E. C., and Horn, V. (1966) Proc. Natl. Acad. Sci. U.S.A. 55, 274-281.
13. Tsuzuki, T., Egashira, A., Igarashi, H., Iwakuma, T., Nakatsuru, Y., Tominaga, Y., Kawate, H., Nakao, K., Nakamura, K., Ide, F., Kura, S., Nakabeppu, Y., Katsuki, M., Ishikawa, T., and Sekiguchi, M. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 11456-11461.
14. Tassotto, M. L., and Mathews, C. K. (2002) J. Biol. Chem. 277, 15807-15812.
15. Abeygunawardana, C., Weber, D. J., Gittis, A. G., Frick, D. N., Lin, J., Miller, A.-F., Bessman, M. J., and Mildvan, A. S. (1995) Biochemistry 34, 14997-15005.
16. Massiah, M. A., Saraswat, V., and Mildvan, A. S. (2002) Abstract 43rd ENC meeting, Asilomar, CA, April 14-19, 2002, Abstract no. W/T P-198, p 263.
17. Abeygunawardana, C., Weber, D. J., Frick, D. N., Bessman, M. J., and Mildvan, A. S. (1993) Biochemistry 32, 13071-13080.
18. Rückert, M., and Otting, G. (2000) J. Am. Chem. Soc. 122, 7793-7797.
19. Ottiger, M., Delaglio, F., and Bax, A. (1998) J. Magn. Reson. 131, 373-378.
20. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR 6, 277-93.
21. Johnson, B. A., and Blevins, R. A. (1994) J. Biomol. NMR 4, 603-614.
22. Lee, W., Revington, M., Arrowsmith, C., and Kay, L. E. (1994) FEBS Lett. 350, 87-90.
23. Massiah, M. A., Abeygunawardana, C., Gittis, A. G., and Mildvan, A. S. (1998) Biochemistry 37, 14701-14712.
24. Comilescu, G., Delaglio, F., and Bax, A. (1999) J. Biomol. NMR 13, 289-302.
25. Stein, E. G., Rice, L. M., and Brunger, A. T. (1997) J. Magn. Reson. 124, 154-164.
26. Brunger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
27. Frick, D. N., Weber, D. J., Abeygunawardana, C., Gittis, A. G., Bessman, M. J., and Mildvan, A. S. (1995) Biochemistry 34, 5577-5586.
28. Tolman, J. R., Flanagan, J. M., Kennedy, M. A., and Prestegard, J. H. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 9279-9283
29. Tjandra, N., and Bax, A. (1997) Science 278, 1111-1114.
30. Clore, G. M., Gronenbom, A. M., and Bax, A. (1998) J. Magn. Reson. 133, 216-221.
31. Clore, G. M., Gronenbom, A. M., and Tjandra, N. (1998) J. Magn. Reson. 131, 159-162.
32. Bai, Y., Milne, J. S., Mayne, L., and Englander, S. W. (1993) Proteins: Struct., Funct., Genet. 17, 75-86.
33. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, pp 123-125, John Wiley and Sons, New York.
34. Weber, D. J., Abeygunawardana, C., Bessman, M. J., and Mildvan, A. S. (1993) Biochemistry 32, 13081-13088.
35. Lin, J., Abeygunawardana, C., Frick, D. N., Bessman, M. J., and Mildvan, A. S. (1996) Biochemistry 35, 6715-6726.
36. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
37. Conyers, G. B., Wu, G., Bessman, M. J., and Mildvan, A. S. (2000) Biochemistry 39, 2347-2354.
38. Fletcher, J. I., Swarbrick, J. D., Maksel, D., Gayler, K. R., and Gooley, P. R. (2002) Structure 10, 205-213.
39. Graham, D. L., Lowe, P. N., Grime, G. W., Marsh, M., Rittinger, K., Smerdon, S. J., Gamblin, S. J., and Eccleston, J. F. (2002) Chem. Biol. 9, 375-381.
40. Sanner, M. F., Olson, A. J., and Spencer, J. C. (1995) Proceedings of Eleventh Association for Computational Machinery Symposium on Computational Geometry, A. C. M. Press, New York, pages C6-C7.
41. Wang, C., Pawley, N. H., and Nicholson, L. K. (2001) J. Mol. Biol. 313, 873-877.
42. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.