Endogenous nitric oxide modulates GABAergic transmission to granule cells in adult rat cerebellum

European Journal of Neuroscience

Volumn 18, Issue 4, 2003, Pages 869-878

  Wall, Mark J ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

6 subunit; Cerebellum; Golgi cell; Nitric oxide synthase

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CEREBELLUM VERMIS; CONTROLLED STUDY; GABAERGIC TRANSMISSION; GOLGI COMPLEX; GRANULE CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CEREBELLUM; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GAMMA-AMINOBUTYRIC ACID; MEMBRANE POTENTIALS; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION;

EID: 0042318593     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02822.x     Document Type: Article

References (47)

1. + channels. J. Physiol. (Lond.), 520, 165-176.
2. Alderton, W.K., Cooper, C.E. & Knowles, R.G. (2001) Nitric oxide synthases: structure, function and inhibition. Biochem. J., 357, 593-615.
3. Borden, L.A., Murali Dhar, T.G., Smith, K.E., Weinshank, R.L., Branchek, T.A. & Gluchowski, C. (1994) Tiagabine, SK & F 89976-A and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur. J. Pharm., 269, 219-224.
4. A receptors. J. Physiol. (Lond.), 497, 753-759.
5. Clarke, J.A. & Amara, S.G. (1994) Stable expression of a neuronal γ-aminobutyric acid transporter, GAT-3 in mammalian cells demonstrates unique pharmacological properties and ion dependence. Mol. Pharm., 46, 550-557.
6. Cupello, A., Mainardi, P., Robello, M. & Thellung, S. (1997) Effect of nitric oxide donors on GABA uptake by rat brain synaptosomes. Neurochem. Res., 22, 1517-1521.
7. D'Angelo, E., De Filippi, G., Rossi, P. & Taglietti, V. (1995) Synaptic excitation of individual rat cerebellar granule cells in situ: evidence for the role of NMDA receptors. J. Physiol. (Lond.), 484, 397-413.
8. Daniel, H., Hemart, N., Jaillard, D. & Crepel, F. (1993) Long-term depression requires nitric oxide and guanosine 3,5 cyclic monophosphate production in rat cerebellar Purkinje cells. Eur. J. Neurosci., 5, 1079-1082.
9. Dieudonné, S. (1998) Submillisecond kinetics and low efficacy of parallel fibre-Golgi cell synaptic currents in the rat cerebellum. J. Physiol. (Lond.), 510, 845-866.
10. Dinnerman, J.L., Dawson, T.M., Schell, M.J., Snowman, A. & Snyder, S.H. (1994) Endothelial nitric oxide synthase localised to hippocampal pyramidal cells: implications for synaptic plasticity. Proc. Natl. Acad. Sci. USA, 91, 4214-4218.
11. Eccles, J.C., Ito, M. & Szentagothai, J. (1967) The cerebellum as a neuronal machine. Springer-Verlag, Berlin.
12. Esplugues, J.V. (2002) NO as a signalling molecule in the nervous system. Br. J. Pharm., 135, 1079-1095.
13. A receptor. Neuroreport, 9, 1089-1092.
14. Garthwaite, J. & Boulton, C.L. (1995) Nitric oxide signalling in the central nervous system. Annu. Rev. Physiol., 57, 683-706.
15. Hamann, M., Rossi, D.J. & Atwell, D. (2002) Tonic and spillover inhibition of granule cells control information flow through the cerebellar cortex. Neuron, 33, 625-633.
16. Hartell, N.A. (1994) cGMP acts within Purkinje cells to produce long term depression via mechanisms involving PKC and PKG. Neuroreport, 5, 833-836.
17. Hartell, N.A., Furuya, S., Jacoby, S. & Okada, D. (2001) Intracellular action of nitric oxide increases cGMP in cerebellar Purkinje cells. Neuroreport, 12, 25-28.
18. Itouji, A., Sakai, N., Tanaka, C. & Saito, N. (1996) Neuronal and glial localization of two GABA transporters (GAT1 and GAT3) in the rat cerebellum. Mol. Brain. Res., 37, 309-316.
19. Kaneda, M., Farrant, M. & Cull-Candy, S.G. (1995) Whole-cell and single channel currents activated by GABA and glycine in granule cells of the rat cerebellum. J. Physiol. (Lond.), 485, 419-435.
20. Korpi, E.R., Kuner, T., Seeburg, P.H. & Luddens, H. (1995) Selecetive antagonist for the cerebellar granule cell specific γ-aminobutyric acid type A receptor. Mol. Pharm., 47, 283-289.
21. Korpi, E.R. & Luddens, H. (1993) Regional gamma-aminobutyric acid sensitivity of t-butylbicyclophosphoro[35s]thionate binding depends on gamma-aminobutyric acid receptor alpha subunit. Mol. Pharm., 44, 97-92.
22. Kriegsfeld, L.J., Eliasson, M.J.L., Demas, G.E., Blackshaw, S., Dawson, T.M., Nelson, R.J. & Snyder, S.H. (1999) Nocturnal motor co-ordination deficits in neuronal nitric oxide synthase knock-out mice. Neuroscience, 89, 311-315.
23. Kumamoto, E. & Murata, Y. (1995) Characterization of GABA current in rat septal cholinergic neurons in culture and its modulation by metal cations. J. Neurophysiol., 74, 2012-2027.
24. Larsson, O.M., Falch, E., Krogsgaard-Larsen, P. & Schousboe, A. (1988) Kinetic characterization of inhibition of γ-aminobutyric acid uptake into cultured neurons and astrocytes by 4,4-diphenyl-3-butenyl derivatives of nipecotic acid and guvacine. J. Neurochem., 50, 818-823.
25. 2+ transients. Neuron, 15, 407-415.
26. Li, J., Chen, S., Lin, R.C. & Smith, S.S. (1997) Cerebellar nitric oxide synthase is expressed within granule cell patches innervated by specific mossy fiber terminals: a developmental profile. Dev. Neurosci., 19, 274-282.
27. Liu, Q-Y., Lopez-Corcuera, B., Mandiyan, S., Nelson, H. & Nelson, N. (1993) Molecular characterization of four pharmacologically distinct γ-aminobutyric acid transporters in mouse brain. J. Biol. Chem., 268, 2106-2112.
28. Llinas, R.R. & Sugimori, M. (1980) Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J. Physiol. (Lond.), 305, 171-195.
29. Palmer, R.M.J., Ashton, D.S. & Moncada, S. (1988) Vascular endothelial cells synthesise nitric oxide from 1-arginine. Nature, 333, 664-666.
30. Paul, V. & Jayakumar, A.R. (2000) A role of nitric oxide as an inhibitor of γ-aminobutyric acid transaminase in rat brain. Brain. Res. Bull., 51, 43-46.
31. Paul, V. & Subramanian, E.H. (2002) Evidence for an involvement of nitric oxide and gamma aminobutyric acid in the anticonvulsant action of 1-arginine on picrotoxin-induced convulsions in rats. Pharm. Bio. Behav., 72, 515-519.
32. Robello, M., Amico, C., Bucossi, G., Cupello, A., Rapallino, M.V. & Thellung, S. (1996) Nitric oxide and GABAA receptor function in the rat cerebral cortex and cerebellar granule cells. Neuroscience, 74, 99-105.
33. Rodrigo, J., Alonso, D., Fernández, A.P., Serrano, J., Richart, A., López, J.C., Santacana, M., Martínez-Murillo, R., Bentura, M.L., Ghiglione, M. & Uttenthal, L.O. (2001) Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation. Brain Res., 909, 20-45.
34. A receptors and glomerular geometry. Neuron, 20, 782-795.
35. Rossi, D.J., Hamann, M. & Attwell, D. (2003) Multiple modes of GABAergic inhibition of rat cerebellar granule cells. J. Physiol. (Lond.), 548, 97-110.
36. A receptor isoforms. Mol. Pharm., 49, 567-579.
37. Southam, E., Morris, R. & Garthwaite, J. (1992) Sources and targets of nitric oxide in rat cerebellum. Neurosci. Lett., 137, 241-244.
38. Spanswick, D., Clark, V.J., Logan, S.D. & Renaud, L.P. (1996) Action of nitric oxide and noradrenaline on sympathetic preganglionic neurones. J. Physiol. (Lond.), 494, P78.
39. A receptor α6 subunit. J. Neurosci., 16, 3630-3640.
40. Vincent, S.R., Williams, J.A., Reiner, P.B. & El-Husseini, A.E.D. (1998) Monitoring neuronal NO release in vivo in cerebellum, thalamus and hippocampus. Prog. Brain Res., 118, 27-35.
41. A receptor expression at adult rat Golgi cell to granule cell synapses. Neuropharmacology, 43, 737-749.
42. A receptor-mediated currents in granule cells of postnatal rat cerebellum. Eur. J. Neurosci., 9, 533-548.
43. Wang, W., Nakayama, T., Inoue, N. & Kato, T. (1998) Quantitative analysis of nitric oxide synthase expressed in developing and differentiating rat cerebellum. Dev. Brain Res., 111, 65-75.
44. A receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase. J. Neurosci., 18, 2342-2349.
45. Wiencken, A.E. & Casagrande, V.A. (1999) Endothelial nitric oxide synthetase (eNOS) in astrocytes: another source of nitric oxide in neocortex. Glia, 26, 280-290.
46. Wu, Y., Wang, W. & Richerson, G.B. (2001) GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of GABA transporter. J. Neurosci., 21, 2630-2639.
47. ω-propyl-L-arginine. J. Med. Chem., 40, 3869-3870.