Evidence for an involvement of nitric oxide and gamma aminobutyric acid in the anticonvulsant action of L-arginine on picrotoxin-induced convulsions in rats

Pharmacology Biochemistry and Behavior

Volumn 72, Issue 3, 2002, Pages 515-519

  Paul, Vanaja ^a   Subramanian, E Harihara ^a  

^a Dr ALM Postgraduate Institute of Basic Medical Sciences   (India)

Author keywords

Convulsions; Gamma aminobutyric acid; L arginine; L NAME; Nitric oxide; Picrotoxin

Indexed keywords

4 AMINOBUTYRIC ACID; ARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PICROTOXIN; ANTICONVULSIVE AGENT; ENZYME INHIBITOR;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; CONVULSION; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNTHESIS; ANIMAL; BRAIN; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; SEIZURE; WISTAR RAT;

ANIMALS; ANTICONVULSANTS; ARGININE; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GAMMA-AMINOBUTYRIC ACID; MALE; NITRIC OXIDE; PICROTOXIN; RATS; RATS, WISTAR; SEIZURES;

EID: 0036011286     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(02)00713-X     Document Type: Article

References (25)

1. Nitric oxide inhibits GABA-evoked current in dorsal root ganglion neuron via PKG-dependent pathway
2. Nitric oxide an endogenous anticonvulsant substance
3. Purification of GABA on small column of Dowex 50 W: Combination with a method for separation of biogenic amines
4. L-Arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepriform cortex
5. Nitric oxide synthase assays
6. Regional levels of GABA in the brain: Rapid semiautomatic assays and prevention of postmortem increase by 3-mercaptopropionic acid
7. Role of nitric oxide in control of synaptic transmission: Effects on neurotransmitter release
8. Nitric oxide induces neurotransmitter release from hippocampal slices
9. Evidence that L-arginine possesses proconvulsant effect mediated through nitric oxide
10. The L-arginine: Nitric oxide pathway
11. Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex
12. A role of nitric oxide as an inhibitor of γ-aminobutyric acid transaminase in rat brain
13. A technique for measurement of clonic convulsions in rats
14. The sex-related difference in the convulsant action of picrotoxin in rats
15. Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents
16. The role of nitric oxide in the kainate-induced seizures in mice
17. Effects of L-NAME, an inhibitor of nitric oxide synthesis on motor function in rats
18. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
19. Role of nitric oxide in modulating the release of dopamine, glutamate and GABA in striatum of the freely moving rat
20. A GABA receptor mechanism in the central nervous system
21. Anticonvulsant effect of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or citrulline formation
22. Effect of ageing on tissue levels of amino acids involved in the nitric oxide pathway in rat brain
23. Role of nitric oxide in the hypersusceptinility to pentylene-tetrazol-induced seizure in diazepam withdrawn mice
24. Neurons in rat hippocampus synthesize nitric oxide
25. Inhibition of nitric oxide synthase activity in cerebral cortical synaptosomes by nitric oxide donors: Evidence for feedback autoregulation