Synthesis of enantiomers of butane-1,2-diacetal-protected glyceraldehyde and of (R,R)-butane-1,2-diacetal-protected glycolic acid

Synthesis

Volumn , Issue 10, 2003, Pages 1598-1602

  Michel, Patrick ^a   Ley, Steven V ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

D mannitol; Diacetal; Glyceraldehydes; L ascorbic acid; hydroxy acid

Indexed keywords

ALDEHYDES; BUTANE; ISOMERS;

SCALABILITY;

SYNTHESIS (CHEMICAL);

ASCORBIC ACID; BUTANE; BUTANE 1,2 DIACETAL GLYCERALDEHYDE; BUTANE 1,2 DIACETAL GLYCOLIC ACID; GLYCERALDEHYDE; GLYCOLIC ACID; MANNITOL; UNCLASSIFIED DRUG;

ARTICLE; ENANTIOMER; ISOMERISM; OXIDATION; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0042243690     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-40519     Document Type: Article

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33. 13 is not reliable because the value increases from-110 to -160 in two hours possibly due to an acid-catalysed decomposition. Nevertheless, the enantiomeric excess of 1 determined by chiral GC proved that the enantiomeric excess of 6 is at least 99%.