-
1
-
-
0001863268
-
-
1999, 1639.
-
Dispiroketals in synthesis. Part 24: D. Laine, M. Fujita and S. V. Ley,/ Chem. Soc,Perkin Trans, l, 1999, 1639.
-
Chem. Soc,Perkin Trans, L
-
-
Laine, D.1
Fujita, M.2
Ley, S.V.3
-
3
-
-
0001568915
-
-
1979, 51, 1875
-
Y. Hirata, D. Uemura, K. Ueda and S. Takano, Pure Appl. Chem., 1979, 51, 1875;
-
Pure Appl. Chem.
-
-
Hirata, Y.1
Uemura, D.2
Ueda, K.3
Takano, S.4
-
4
-
-
0019470355
-
-
1981, 22, 1909, 2781
-
D. Uemura, K. Ueda, Y. Hirata, H. Naoki and T. Iwashita, Tetrahedron Lett., 1981, 22, 1909, 2781;
-
Tetrahedron Lett.
-
-
Uemura, D.1
Ueda, K.2
Hirata, Y.3
Naoki, H.4
Iwashita, T.5
-
5
-
-
0015245199
-
-
1971, 172, 495; R. E. Moore and G. Bartoiini, J. Am. Chem. Soc., 1981,103,2491.
-
P. J. Scheuer and R. E. Moore, Science, 1971, 172, 495; R. E. Moore and G. Bartoiini, J. Am. Chem. Soc., 1981,103,2491.
-
Science
-
-
Scheuer, P.J.1
Moore, R.E.2
-
6
-
-
0001233216
-
-
1982, 104, 1109
-
N. Minami, S. S. Ko and Y. Kishi, J. Am. Chem. Soc., 1982, 104, 1109;
-
J. Am. Chem. Soc.
-
-
Minami, N.1
Ko, S.S.2
Kishi, Y.3
-
7
-
-
33746456715
-
-
1982,104, 3315
-
A. \V. M. Lee, V. S. Martin, S. Masamune, K. B. Sharpless and F. J. Walker, J. Am. Chem. Soc., 1982,104, 3315;
-
J. Am. Chem. Soc.
-
-
Lee, A.V.M.1
Martin, V.S.2
Masamune, S.3
Sharpless, K.B.4
Walker, F.J.5
-
8
-
-
0020645466
-
-
1983,220, 949.
-
S. Y. Ko, A. W. M. Lee, S. Masamune, L. A. Reed, III, K. B. Sharpless and F. J. Walker, Science, 1983,220, 949.
-
Science
-
-
Ko, S.Y.1
Lee, A.W.M.2
Masamune, S.3
Reed III, L.A.4
Sharpless, K.B.5
Walker, F.J.6
-
9
-
-
0001412181
-
-
1995,2,365.
-
For a comprehensive review of dispiroketal chemistry see: S. V. Ley, R. Downham, P. J. Edwards, t. E. Innés and M. Woods, Contemp. Org.Synth., 1995,2,365.
-
T. E. Innés and M. Woods, Contemp. Org.Synth.
-
-
Ley, S.V.1
Downham, R.2
Edwards, P.J.3
-
13
-
-
33748601612
-
-
1998, 51
-
N. L. Douglas, S. V. Ley, U. Lucking and S. L. Warriner, J. Chem. Soc., Perkin Trans. 1, 1998, 51;
-
J. Chem. Soc., Perkin Trans. 1
-
-
Douglas, N.L.1
Ley, S.V.2
Lucking, U.3
Warriner, S.L.4
-
14
-
-
0027772575
-
-
1993,34, 8523.
-
G.-J. Boons, P. Grice, R. Leslie, S. V. Ley and L. L. Yeung, Tetrahedron Lett., 1993,34, 8523.
-
Tetrahedron Lett.
-
-
Boons, G.-J.1
Grice, P.2
Leslie, R.3
Ley, S.V.4
Yeung, L.L.5
-
15
-
-
0028129922
-
-
1994, 35, 7447
-
B. C. B. Bezuidenhoudt, G. H. Castle and S. V. Ley, Tetrahedron Lett., 1994, 35, 7447;
-
Tetrahedron Lett.
-
-
Bezuidenhoudt, B.C.B.1
Castle, G.H.2
Ley, S.V.3
-
16
-
-
0028129923
-
-
1994, 35, 7451
-
B. C. B. Bezuidenhoudt, G. H. Castle, J. V. Geden and S. V. Ley, Tetrahedron Lett., 1994, 35, 7451;
-
Tetrahedron Lett.
-
-
Bezuidenhoudt, B.C.B.1
Castle, G.H.2
Geden, J.V.3
Ley, S.V.4
-
18
-
-
33746466428
-
-
In referring to diastereoisomers obtained from reaction of nonchiral starting materials, their racemic nature is assumed and only one enantiomeric form is depicted in their formulae.
-
In referring to diastereoisomers obtained from reaction of nonchiral starting materials, their racemic nature is assumed and only one enantiomeric form is depicted in their formulae.
-
-
-
-
19
-
-
0028284175
-
-
1994,50, 7157.
-
G.-J. Boons, R. Downham, K. S. Kim, S. V. Ley and M. Woods, Tetrahedron, 1994,50, 7157.
-
Tetrahedron
-
-
Boons, G.-J.1
Downham, R.2
Kim, K.S.3
Ley, S.V.4
Woods, M.5
-
21
-
-
19644376049
-
-
1990, 55, 1957
-
J.-N. Denis, A. Correa and A. E. Greene, J. Org. Chem., 1990, 55, 1957;
-
J. Org. Chem.
-
-
Denis, J.-N.1
Correa, A.2
Greene, A.E.3
-
22
-
-
0028058771
-
-
1994,59, 5104.
-
Z.-M. Wang, H. C. Kolb and K. B. Sharpless, J. Org. Chem., 1994,59, 5104.
-
J. Org. Chem.
-
-
Wang, Z.-M.1
Kolb, H.C.2
Sharpless, K.B.3
-
23
-
-
84970564830
-
-
1990,43, 1195.
-
B. R. Matthews, W. R. Jackson, H. A. Jacobs and K. G. Watson, Aiist. J. Chcm., 1990,43, 1195.
-
Aiist. J. Chcm.
-
-
Matthews, B.R.1
Jackson, W.R.2
Jacobs, H.A.3
Watson, K.G.4
-
24
-
-
33746394934
-
-
During further studies of these aldol reactions, it was found that replacing DMPU by HMPA enhanced the nucleophilicity of the enolate of 18 (antipode of 4). Under these conditions it was possible (Figure Presented) Reagents and conditions: i, Pr"2NH, Bu"Li, THF-HMPA (3:1 mixture), -78 °C, 30 min then pivaldehyde at -78 °C, 30 min. to carry out the reaction with pivalaldehyde and a single compound was isolated in 58% yield. The stereochemistry of this compound was not formally established but was predicted to be erythro according to the transition states shown in Scheme 2.
-
During further studies of these aldol reactions, it was found that replacing DMPU by HMPA enhanced the nucleophilicity of the enolate of 18 (antipode of 4). Under these conditions it was possible (Figure Presented) Reagents and conditions: i, Pr"2NH, Bu"Li, THF-HMPA (3:1 mixture), -78 °C, 30 min then pivaldehyde at -78 °C, 30 min. to carry out the reaction with pivalaldehyde and a single compound was isolated in 58% yield. The stereochemistry of this compound was not formally established but was predicted to be erythro according to the transition states shown in Scheme 2.
-
-
-
-
25
-
-
34250667360
-
-
1986, 42, 447.
-
For a general review, see: J. Jurczak, S. Pikul and T. Bauer, Tetrahedron, 1986, 42, 447.
-
Tetrahedron
-
-
Jurczak, J.1
Pikul, S.2
Bauer, T.3
-
26
-
-
0021775497
-
-
1985,24, 1.
-
For a general review, see: S. Masamune, W. Choy, J. S. Petersen and L. R. Site, Angew. Clieni., Int. Ed. Engl., 1985,24, 1.
-
Angew. Clieni., Int. Ed. Engl.
-
-
Masamune, S.1
Choy, W.2
Petersen, J.S.3
Site, L.R.4
-
27
-
-
33845556810
-
-
1981,46, 1296
-
(a) C. H. Heathcock, C. T. White, J. J. Morrison and D. vanDerveer, J. Org. Chem., 1981,46, 1296;
-
J. Org. Chem.
-
-
Heathcock, C.H.1
White, C.T.2
Morrison, J.J.3
Vanderveer, D.4
-
29
-
-
0000101367
-
-
1979,101,7077.
-
C. H. Heathcock, M. C. Pirrung, C. T. Buse, J. P. Hagan, S. D. Young and J. E. Sohn, J. Am. Chem. Soc., 1979,101,7077.
-
J. Am. Chem. Soc.
-
-
Heathcock, C.H.1
Pirrung, M.C.2
Buse, C.T.3
Hagan, J.P.4
Young, S.D.5
Sohn, J.E.6
-
32
-
-
0000679560
-
-
1980,45,3846.
-
C. H. Heathcock, S. D. Young, J. P. Hagan, M. C. Pirrung, C. T. White and D. vanDerveer, J. Org. Chem., 1980,45,3846.
-
J. Org. Chem.
-
-
Heathcock, C.H.1
Young, S.D.2
Hagan, J.P.3
Pirrung, M.C.4
White, C.T.5
Vanderveer, D.6
-
34
-
-
33748730701
-
-
1977, 33, 2933.
-
Y. Senda, B. Kamiyama and S. Imaizumi, Tetrahedron, 1977, 33, 2933.
-
Tetrahedron
-
-
Senda, Y.1
Kamiyama, B.2
Imaizumi, S.3
-
36
-
-
0342767432
-
-
1979,35, 2583 .
-
S. Hagen, T. Anthonsen and L. Kilaas, Tetrahedron, 1979,35, 2583 .
-
Tetrahedron
-
-
Hagen, S.1
Anthonsen, T.2
Kilaas, L.3
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