Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol

Carcinogenesis

Volumn 24, Issue 7, 2003, Pages 1247-1255

  Mammen, Jennifer S ^a   Pittman, Gary S ^b   Li, Ying ^a   Abou Zahr, Fadi ^c   Bejjani, Bassem A ^c   Bell, Douglas A ^b   Strickland, Paul T ^a   Sutter, Thomas R ^a,d  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c Houston   (United States)

^d UNIVERSITY OF MEMPHIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; ALANINE; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; CARCINOGEN; CYTOCHROME P450 1B1; GLUTAMIC ACID; GLYCINE; LEUCINE; PROLINE; SERINE; TRYPTOPHAN; VALINE;

AFRICA; ALLELE; ARTICLE; ASIAN; CANCER SUSCEPTIBILITY; CONGENITAL GLAUCOMA; CONTROLLED STUDY; DELETION MUTANT; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; ETHNOLOGY; EUROPE; GENE FREQUENCY; GENE MUTATION; GENETIC DIFFERENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; METABOLISM; MICHAELIS MENTEN KINETICS; MICROSOME; MISSENSE MUTATION; NONHUMAN; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; STATISTICAL SIGNIFICANCE;

AFRICAN CONTINENTAL ANCESTRY GROUP; ARYL HYDROCARBON HYDROXYLASES; DIHYDROXYDIHYDROBENZOPYRENES; DNA PRIMERS; GENE FREQUENCY; GENOTYPE; GLAUCOMA; HAPLOTYPES; HUMANS; MICROSOMES; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NADH DEHYDROGENASE; OXIDATION-REDUCTION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; SACCHAROMYCES CEREVISIAE;

EID: 0042168972     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgg088     Document Type: Article

References (38)

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