Generation of 2,3,7,8-TCDD-metabolizing enzyme by modifying rat CYP1A1 through site-directed mutagenesis

Biochemical and Biophysical Research Communications

Volumn 308, Issue 3, 2003, Pages 511-517

  Shinkyo, Raku ^a   Sakaki, Toshiyuki ^a   Takita, Teisuke ^a   Ohta, Miho ^b   Inouye, Kuniyo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Koshien Junior College   (Japan)

Author keywords

CYP1A1; Cytochrome P450; Metabolism of dioxin; Site directed mutagenesis; TCDD

Indexed keywords

CYTOCHROME P450 1A1; DIOXIN; POLYCHLORINATED DIBENZODIOXIN;

AMINO ACID SUBSTITUTION; ARTICLE; AUXOTROPHIC MUTANT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; GEL CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHYTOREMEDIATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; SOIL POLLUTION;

MAMMALIA;

EID: 0042165052     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01439-6     Document Type: Article

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