Syntheses of 3-ethylidenequinuclidine derivatives as squalene synthase inhibitors. Part 2: Enzyme inhibition and effects on plasma lipid levels

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 17, 2003, Pages 3735-3745

  Ishihara, Tsukasa ^a   Kakuta, Hirotoshi ^a   Moritani, Hiroshi ^a   Ugawa, Tohru ^a   Sakamoto, Shuichi ^a   Tsukamoto, Shin Ichi ^a   Yanagisawa, Isao ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (QUINUCLIDIN 3 YLIDENE)ETHOXY] 9H CARBAZOLE; 2 [2 FLUORO 2 (QUINUCLIDIN 3 YLIDENE)ETHOXY] 9H CARBAZOLE; CARBAZOLE DERIVATIVE; QUINUCLIDINE DERIVATIVE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; GUINEA PIG; HAMSTER; HEPATOMA CELL; HUMAN; HUMAN CELL; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER TOXICITY; MALE; NONHUMAN; RAT;

CRICETINAE;

EID: 0042121523     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00336-5     Document Type: Article

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