RPR 101821, a new potent cholesterol-lowering agent: Inhibition of squalene synthase and 7-dehydrocholesterol reductase

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 2, 1996, Pages 233-240

  Amin, Dilip ^a   Rutledge, Ruth Z ^a   Needle, Saul J ^a   Hele, Dave J ^b   Neuenswander, Kent ^a   Bush, Ray C ^b   Bilder, Glenda E ^a   Perrone, Mark H ^a  

^a SANOFI   (France)

^b Dagenham Research Center   (United Kingdom)

Author keywords

7 Dehydrocholesterol; Cholesterol; Lovastatin; Reductase; Squalene synthase

Indexed keywords

2 [4 (2 BENZOXAZOLYL)BENZYLOXY]CYCLOHEXYLAMINE; 4 [2 [1 (4 CHLOROCINNAMYL) 4 PIPERAZINYL]ETHYL]BENZOIC ACID; 7 DEHYDROCHOLESTEROL; 7 DEHYDROCHOLESTEROL REDUCTASE; 7 DEHYDROCHOLESTEROL REDUCTASE INHIBITOR; CHOLESTEROL; COLESTYRAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; MEVINOLIN; SQUALENE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; LIVER MICROSOME METABOLISM; MALE; MARMOSET; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0030034123     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00168762     Document Type: Article

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