메뉴 건너뛰기




Volumn 3, Issue 2-3, 1999, Pages 301-320

Combinatorial Optimization in Rapidly Mutating Drug-Resistant Viruses

Author keywords

Artificial intelligence; Clinical treatment; Drug resistance; Expert system; HIV; Mutants; Mutations; Retrovirus; Virus

Indexed keywords


EID: 0042044292     PISSN: 13826905     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1009846028730     Document Type: Article
Times cited : (21)

References (29)
  • 4
    • 0345065422 scopus 로고    scopus 로고
    • Application of a genotypic driven rule-based expert artificial intelligence computer system in treatment experienced HIV-infected patients. Immunologic and virologie response
    • page extended abstract #32297, Geneva, Switzerland
    • P.J. Cimoch, D.M. See, M.J. Pazzani, W.M. Reiter, R.H. Lathrop, W.A. Fasone, and J.G. Tilles, "Application of a genotypic driven rule-based expert artificial intelligence computer system in treatment experienced HIV-infected patients. Immunologic and virologie response," in Proc. of the 12th World AIDS Conf., page extended abstract #32297, Geneva, Switzerland, 1998.
    • (1998) Proc. of the 12th World AIDS Conf.
    • Cimoch, P.J.1    See, D.M.2    Pazzani, M.J.3    Reiter, W.M.4    Lathrop, R.H.5    Fasone, W.A.6    Tilles, J.G.7
  • 6
    • 0028421858 scopus 로고
    • An expert system for the interpretation of flow cytometric immunophenotyping data
    • L. Diamond, D. Nguyen, H. Jouault, M. Imbert, and C. Sultan, "An expert system for the interpretation of flow cytometric immunophenotyping data," J. of Clinical Computing, vol. 22, pp. 50-58, 1994.
    • (1994) J. of Clinical Computing , vol.22 , pp. 50-58
    • Diamond, L.1    Nguyen, D.2    Jouault, H.3    Imbert, M.4    Sultan, C.5
  • 8
    • 0028329899 scopus 로고
    • Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene
    • Z. Gu, Q. Gao, H. Fang, M. Parniak, B. Brenner, and M. Wainberg, "Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene," Leukemia, vol. 8S1, pp. 5166-5169, 1994.
    • (1994) Leukemia , vol.8 S1 , pp. 5166-5169
    • Gu, Z.1    Gao, Q.2    Fang, H.3    Parniak, M.4    Brenner, B.5    Wainberg, M.6
  • 10
    • 0030048748 scopus 로고    scopus 로고
    • Multidrug-resistant human immunodeficiency type I strains resulting from combination antiretroviral therapy
    • A.K. Iversen, R.W. Shafer, K. Wearly et al., "Multidrug-resistant human immunodeficiency type I strains resulting from combination antiretroviral therapy," J. Virology, vol. 70, pp. 1086-1090, 1996.
    • (1996) J. Virology , vol.70 , pp. 1086-1090
    • Iversen, A.K.1    Shafer, R.W.2    Wearly, K.3
  • 13
    • 0026565278 scopus 로고
    • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
    • P. Kellam, C. Boucher, and B.A. Larder, "Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine," Proc. Natl. Acad. Sci. USA, vol. 89, pp. 1934-1938, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1934-1938
    • Kellam, P.1    Boucher, C.2    Larder, B.A.3
  • 14
    • 0029561716 scopus 로고
    • Triple combinations: Present and future
    • J. Lange, "Triple combinations: Present and future," J. of AIDS and Human Retrovirology, vol. 10, no. 1, pp. S77-82, 1995.
    • (1995) J. of AIDS and Human Retrovirology , vol.10 , Issue.1
    • Lange, J.1
  • 16
    • 57349200753 scopus 로고    scopus 로고
    • EON: A component-based approach to automation of protocol-directed therapy
    • M. Musen, S. Tu, A. Das, and Y. Shahar, "EON: A component-based approach to automation of protocol-directed therapy," J. Amer. Medical Informatics Assoc., vol. 3, pp. 367-388, 1996.
    • (1996) J. Amer. Medical Informatics Assoc. , vol.3 , pp. 367-388
    • Musen, M.1    Tu, S.2    Das, A.3    Shahar, Y.4
  • 17
    • 0028907609 scopus 로고
    • Development of a controlled medical terminology: Knowledge acquisition and knowledge representation
    • M. Musen, K. Wieckert, E. Miller, K. Campbell, and L. Fagan, "Development of a controlled medical terminology: Knowledge acquisition and knowledge representation," Methods of Information in Medicine, vol. 34, pp. 85-95, 1995.
    • (1995) Methods of Information in Medicine , vol.34 , pp. 85-95
    • Musen, M.1    Wieckert, K.2    Miller, E.3    Campbell, K.4    Fagan, L.5
  • 18
  • 20
    • 0030723424 scopus 로고    scopus 로고
    • Application of an expert system in the management of HIV-infected patients
    • M. Pazzani, D. See, E. Shroeder, and J. Tilles, "Application of an expert system in the management of HIV-infected patients," J. of AIDS and Human Retrovirology, vol. 15, pp. 356-362, 1997.
    • (1997) J. of AIDS and Human Retrovirology , vol.15 , pp. 356-362
    • Pazzani, M.1    See, D.2    Shroeder, E.3    Tilles, J.4
  • 21
    • 0032568196 scopus 로고    scopus 로고
    • The frequency of resistant mutant virus before antiviral therapy
    • R.M. Ribeiro, S. Bonhoeffer, and M.A. Nowak, "The frequency of resistant mutant virus before antiviral therapy," J. AIDS, vol. 12, pp. 461-465, 1998.
    • (1998) J. AIDS , vol.12 , pp. 461-465
    • Ribeiro, R.M.1    Bonhoeffer, S.2    Nowak, M.A.3
  • 24
    • 0029687620 scopus 로고    scopus 로고
    • Development of a knowledge-based electronic patient record
    • C. Safran, D. Rind, D. Sands, R. Davis, J. Wald, and W. Slack, "Development of a knowledge-based electronic patient record," M.D. Computing, vol. 13, pp. 46-54, 1996.
    • (1996) M.D. Computing , vol.13 , pp. 46-54
    • Safran, C.1    Rind, D.2    Sands, D.3    Davis, R.4    Wald, J.5    Slack, W.6
  • 25
    • 0028483123 scopus 로고
    • Methods in the Virtual Wetlab I: Rule-based reasoning driven by nearest-neighbor lattice dynamics
    • H. Sieburg, "Methods in the Virtual Wetlab I: Rule-based reasoning driven by nearest-neighbor lattice dynamics," AI in Medicine, vol. 6, pp. 301-319, 1994.
    • (1994) AI in Medicine , vol.6 , pp. 301-319
    • Sieburg, H.1
  • 27
    • 0028057488 scopus 로고
    • An architecture for knowledge-based construction of decision models
    • F. Sonnenberg, C. Hagerty, and C. Kulikowski, "An architecture for knowledge-based construction of decision models," Medical Decision Making, vol. 14, pp. 27-39, 1994.
    • (1994) Medical Decision Making , vol.14 , pp. 27-39
    • Sonnenberg, F.1    Hagerty, C.2    Kulikowski, C.3
  • 28
    • 0029311031 scopus 로고
    • Ontology-based configuration of problem-solving methods and generation of knowledge-acquisition tools
    • S. Tu, H. Eriksson, J. Gennari, Y. Shahar, and M. Musen, "Ontology-based configuration of problem-solving methods and generation of knowledge-acquisition tools," AI in Medicine, vol. 7, pp. 257-289, 1995.
    • (1995) AI in Medicine , vol.7 , pp. 257-289
    • Tu, S.1    Eriksson, H.2    Gennari, J.3    Shahar, Y.4    Musen, M.5
  • 29
    • 0029932553 scopus 로고    scopus 로고
    • An integrated rule- and case-based approach to AIDS initial assessment
    • L. Xu, "An integrated rule- and case-based approach to AIDS initial assessment," Intl. J. of Bio-Medical Computing, vol. 40, pp. 197-207, 1996.
    • (1996) Intl. J. of Bio-Medical Computing , vol.40 , pp. 197-207
    • Xu, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.