Antinociceptive effects of methysergide in various pain models

Pharmacology

Volumn 69, Issue 2, 2003, Pages 93-101

  Chung, Ki Myung ^a   Choi, Seong Soo ^b   Han, Ki Jung ^b   Han, Eun Jung ^b   Lee, Han Kyu ^b   Suh, Hong Won ^b  

^a Gangneung Wonju National University   (South Korea)

^b Hallym University   (South Korea)

Author keywords

5,7 Dihydroxytriptamine; Antinociception; Excitatory amino acid; Formalin test; Methysergide; N (2 chloroethyl) N ethyl 2 bromobenzylamine; Serotonin receptor antagonist; Substance P

Indexed keywords

2 BROMO N (2 CHLOROETHYL) N ETHYLBENZYLAMINE; 5,7 DIHYDROXYTRYPTAMINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; EXCITATORY AMINO ACID; FORMALDEHYDE; GLUTAMIC ACID; KAINIC ACID; METHYSERGIDE MALEATE; N METHYL DEXTRO ASPARTIC ACID; NALOXONE; SEROTONIN ANTAGONIST; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DILUTION; DISEASE DURATION; DISEASE MODEL; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; DRUG MECHANISM; FOOT; INHIBITION KINETICS; INJECTION; LICKING; MALE; MEASUREMENT; MOUSE; NONHUMAN; NORADRENERGIC SYSTEM; PAIN; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SPINAL CORD; TIME;

ANALGESIA; ANIMALS; BEHAVIOR, ANIMAL; FORMALDEHYDE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SPINAL; MALE; METHYSERGIDE; MICE; MICE, INBRED ICR; PAIN; SEROTONIN ANTAGONISTS;

EID: 0041884754     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072362     Document Type: Article

References (57)

1. Vaccarino AL, Tasker RAR, Melzack R: Systemic administration of naloxone produces analgesia in BALB/c mice. Neurosci Lett 1988; 84:103-107.
2. Vaccarino AL, Tasker RAR, Melzack R: Analgesia produced by normal doses of opiate antagonists alone and in combination with morphine. Pain 1989;36:103-109.
3. Poulos CX, Knoke DM, Le AD, Cappell H: Naloxone-induced analgesia and morphine supersensitivity effects are contingent upon prior exposure to analgesic testing. Psychopharmacology 1990;100:31-35.
4. Bianchi M, Panerai AE: Naloxone-induced analgesia: Involvement of kappa-opiate receptors. Pharmacol Biochem Behav 1993;46:145-148.
5. Walker MJ, Poulos CX, Le AD: Effects of acute selective 5-HT1, 5-HT2, 5-HT3 receptor and alpha-2-adrenoceptor blockade on naloxone-induced antinociception. Psychopharmacology (Berl) 1994;113:527-533.
6. Zemlan FP, Kow L, Pfaff DW: Spinal serotonin (5-HAT) receptor subtypes and nociception. J Pharmacol Exp Ther 1983;226:477-485.
7. Solomon RE, Gebhart GF: Mechanisms of effect of intrathecal serotonin on nociception and blood pressure in rats. J Pharmacol Exp Ther 1988;245:905-912.
8. Bardin L, Tarayre JP, Koek W, Colpaert FC: In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia. Eur J Pharmacol 2001;42:109-114.
9. Wang YX, Bowersox SC, Pettus M, Gao D: Antinociceptive properties of fenfluramine, a serotonin reuptake inhibitor, in a rat model of neuropathy. J Pharmacol Exp Ther 1999;291: 1008-1016.
10. Obata H, Saito S, Sasaki M, Ishizaki K, Goto F: Antiallodynic effect of intrathecally administered 5-HT2 agonists in rats with nerve ligation. Pain 2001;90:173-179.
11. Sawynok J: The role of ascending and descending noradrenergic and serotoninergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. Can J Physiol Pharmacol 1989;67:975-988.
12. Ren K, Randich A, Gebhart GF: Spinal serotonergic and kappa opioid receptors mediate facilitation of the tail flick reflex produced by vagal afferent stimulation. Pain 1991;45:321-329.
13. Tjølsen A, Berge OG, Hole K: Lesions of bulbo-spinal serotonergic or noradrenergic pathways reduce nociception as measured by the formalin test. Acta Physiol Scand 1991;142:229-236.
14. Pertovaara A, Keski-Vakkuri U, Kalmari J, Wie H, Panula P: Response properties of neurons in the rostroventromedial medulla of neuropathic rats: Attempted modulation of responses by [1Dme]NPYF, a neuropeptideFF analogue. Neuroscience 2001;105:457-468.
15. Hunskaar S, Hole K: The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain. Pain 1987;30:103-114.
16. Wheeler-Aceto H, Porreca F, Cowan A: The rat paw formalin test: Comparison of noxious agents. Pain 1990;40:229-238.
17. Omote K, Kawamata T, Kawamata M, Namiki A: Formalin-induced nociception activates a monoaminergic descending inhibitory system. Brain Res 1998;814:194-198.
18. Martin WJ, Gupta NK, Loo CM, Rohde DS, Basbaum AI: Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain 1999;80:57-65.
19. Fasmer OB, Berge OG, Hole K: Changes in nociception after lesions of descending seroton-ergic pathways induced with 5,6-dihydroxytryptamine. Different effects in the formalin and tail-flick tests. Neuropharmacology 1985; 24:729-734.
20. Hylden JL, Wilcox GL: Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice. Brain Res 1981;217:212-215.
21. Chung KM, Lee KC, Song DK, Huh SO, Choi MR, Kim YH, Suh HW: Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice. Brain Res 2000;867:246-249.
22. Chung KM, Lee KC, Choi SS, Suh HW: Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin and substance P in mice. Brain Res Bull 2001;54: 537-542.
23. Hunskaar, Fasmer OB, Hole K: Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods 1985;14:69-76.
24. Berge OG, Fasmer OB, Tveiten L, Hole K: Selective neurotoxic lesions of descending serotonergic and noradrenergic pathways in the rat. J Neurochem 1985;44:1156-1161.
25. Suh HH, Hong JS, Tseng LF: Intrathecal DSP-4, 6-hydroxydopamine and 5,7-dihydroxytryptamine differentiate intracerebroventricular β-endorphin- from morphine-induced antinociception in the mouse. Pharmacol Commun 1992;1:227-232.
26. Zhong FX, Ji XQ, Tsou K: Intrathecal DSP4 selectively depletes spinal noradrenaline and attenuates morphine analgesia. Eur J Pharma-col 1985;116:327-330.
27. Sawynok J, Reid A, Nance D: Spinal antinociception by adenosine analogs and morphine after intrathecal administration of the neurotoxins capsaicin, 6-hydroxydopamine and 5,7-dihydroxytryptamine. J Pharmacol Exp Ther 1991;258:370-380.
28. Pang I-H, Vasko MR: Effect of depletion of spinal cord norepinephrine on morphine-induced antinociception. Brain Res 1986;371:171-176.
29. Puig S, Rivot JP, Besson JM: Effect of subcutaneous administration of the chemical algogen formalin, on 5-HT metabolism in the nucleus raphe magnus and the medullary dorsal horn: A voltammetric study in freely moving rats. Brain Res 1992;590:250-254.
30. 2A/2C receptors on nociception in rats. Pharmacol Biochem Behav 1997;56:523-527.
31. 2A/2C receptors augments nociceptive responses in the rat. Brain Res 2001; 910:179-181.
32. Coderre TJ, Yashpal K: Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model. Eur J Neurosci 1994;6:1328-1334.
33. Oyama T, Ueda M, Kuraishi Y, Akaike A, Satoh M: Dual effect of serotonin on formalin-induced nociception in the rat spinal cord. Neurosci Res 1996;25:129-135.
34. Backus LI, Sharp T, Grahame-Smith DG: Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors. Br J Pharmacol 1990;100:793-799.
35. 2 receptors in rats. Psychopharmacology 1998;140:69-74.
36. 2A receptors in the spinal cord and spinal ganglia of the adult rat. Brain Res 1998;797:118-124.
37. Hylden JLK, Wilcox GL: Intrathecal serotonin in mice: Analgesia and inhibition of a spinal action of substance P. Life Sci 1983;33:789-795.
38. 2 receptors in spinal cord in the control of nociceptive responsiveness. Neuropharmacology 1991;30:727-731.
39. Fasmer OB, Berge OG, Hole K: Similar behavioural effects of 5-hydroxytryptamine and substance P injected intrathecally in mice. Neuropharmacology 1983;22:485-487.
40. Crisp T, Stafinsky JL, Spanos LJ, Uram M, Perni VC, Donepudi HB: Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord. Gen Pharmacol 1991;22:247-251.
41. 3 receptor subtypes modulate responses to noxious colorectal distension in the rat. Brain Res 1991;538:64-75.
42. Carlton SM, Hargett GL, Coggeshall RE: Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. Neurosci Lett 1995;197:25-28.
43. Zhou S, Bonasera L, Carlton SM: Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats. Neuroreport 1996;7:895-900.
44. Lawand NB, Willis WD, Westlund KN: Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats. Eur J Pharmacol 1997;324:169-177.
45. Omote K, Kawamata M, Namiki A: Formalin-induced release of excitatory amino acids in the skin for the rat hindpaw. Brain Res 1998;787: 161-164.
46. Davidson EM, Goggeshall RE, Carlton SM: Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test. Neuroreport 1997;8: 941-946.
47. 2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation. Pain 2001;92:213-218.
48. Yashpal K, Fisher K, Chabot J, Coderre TJ: Differential effects of NMDA and group 1 mGIuR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats. Pain 2001;94:17-29.
49. Fields HL, Basbaum AI, Clanton CH, Anderson SD: Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons. Brain Res 1977;126:441-453.
50. Fields HL, Basbaum AI: Brainstem control of spinal pain transmission neurons. Annu Rev Physiol 1978;40:217-248.
51. Yaksh TL, Wilson PR: Spinal serotonin terminal system mediates antinociception. J Pharmacol Exp Ther 1979;208:446-453.
52. Aimone LD, Jones SL, Gebhart GF: Stimulation-produced descending inhibition from the periaqueductal gray and nucleus raphe magnus in the rat: Mediation by spinal monoamines but not opioids. Pain 1987;31:123-136.
53. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP: International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 1994;46:157-203.
54. Silberstein SD: Comprehensive management of headache and depression. Cephalalgia 1998; 18:50-55.
55. 1 receptor agonist after lesion of raphe-spinal serotonergic neurones. Pharmacol Toxicol 1992;71:62-64.
56. Archer T, Jonsson G, Minor BG, Post C: Noradrenergic-serotonergic interactions and nociception in the rat. Eur J Pharmacol 1986;120: 295-307.
57. Post C, Persson ML, Archer T, Minor BG, Danysz W, Sundstrom E: Increased antinociception by alpha-adrenoceptor drugs after spinal cord noradrenaline depletion. Eur J Pharmacol 1987;137:107-116.