Stimulation of T-helper cell gamma interferon and immunoglobulin G responses specific for Babesia bovis rhoptry-associated protein 1 (RAP-1) or a RAP-1 protein lacking the carboxy-terminal repeat region is insufficient to provide protective immunity against virulent B. bovis Challenge

Infection and Immunity

Volumn 71, Issue 9, 2003, Pages 5021-5032

  Norimine, Junzo ^a   Mosqueda, Juan ^a,b   Suarez, Carlos ^a   Palmer, Guy H ^a   McElwain, Terry F ^a   Mbassa, Gabriel ^a,c   Brown, Wendy C ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b INSTITUTO NACIONAL DE INVESTIGACIONES FORESTALES   (Mexico)

^c SOKOINE UNIVERSITY OF AGRICULTURE   (Tanzania)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CD4 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 12; RHOPTRY ASSOCIATED PROTEIN 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; BABESIA BOVIS; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; CATTLE; CONTROLLED STUDY; HELPER CELL; HYPOTHESIS; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; T LYMPHOCYTE; TH1 CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; BABESIA BOVIS; BABESIOSIS; CATTLE; CATTLE DISEASES; CELL LINE; EPITOPE MAPPING; IMMUNOGLOBULIN G; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MALE; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PEPTIDE FRAGMENTS; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; TH1 CELLS; VACCINES, SYNTHETIC;

EID: 0041823439     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.9.5021-5032.2003     Document Type: Article

References (46)

1. Bennett, S., and E. M. Riley. 1992. The statistical analysis of data from immunoepidemiological studies. J. Immunol. Methods 146:229-239.
2. Beyer, J. C., R. W. Stich, W. C. Brown, and W. P. Cheevers. 1998. Cloning and expression of caprine interferon-gamma. Gene 210:103-108.
3. Brown, W. C., K. S. Logan, G. G Wagner, and C. L. Tetzlaff. 1991. Cell-mediated immune responses to Babesia bovis antigens in cattle following infection with tick-derived or cultured parasites. Infect. Immun. 59:2418-2426.
4. Brown, W. C., T. F. McElwain, I. Hötzel, B. J. Ruef, A. C. Rice-Ficht, R. W. Stich, C. E. Suarez, D. M. Estes, and G. H. Palmer. 1998. Immunodominant T-cell antigens and epitopes of Babesia bovis and Babesia bigemina. Ann. Trop. Med. Parasitol. 92:473-482.
5. + T-lymphocyte clones specific for rhoptry-associated protein 1 of Babesia bigemina stimulate enhanced immunoglobulin G1 (IgG1) and IgG2 synthesis. Infect. Immun. 67:155-164.
6. Brown, W. C., T. F. McElwain, B. J. Ruef, C. E. Suarez, V. Shkap, C. G. Chitko-McKown, A. C. Rice-Ficht, and G. H. Palmer. 1996. Babesia bovis rhoptry-associated protein-1 is immunodominant for T helper cells of immune cattle and contains T-cell epitopes conserved among geographically distant B. bovis strains. Infect. Immun. 64:3341-3350.
7. + T lymphocyte epitopes that elicit strong recall responses. J. Immunol. 166:1114-1124.
8. Brown, W. C., and G. H. Palmer. 1999. Designing blood stage-vaccines against Babesia bovis and B. bigemina. Parasitol. Today 15:275-281.
9. + T lymphocyte responses in B. bovis-immune cattle. Mol. Biochem. Parasitol. 118:97-109.
10. + T-lymphocyte and immunoglobulin G2 responses in calves immunized with Anaplasma marginale outer membranes and protected against homologous challenge. Infect. Immun. 66:5406-5413.
11. Commins, M. A., B. V. Goodger, and I. G. Wright. 1985. Proteinases in the lysate of bovine erythrocytes infected with Babesia bovis: initial vaccination studies. Int. J. Parasitol. 15:491-495.
12. Dalrymple, B. P. 1993. Molecular variation and diversity in candidate vaccines from Babesia. Acta Trop. 53:227-238.
13. Dalrymple, B. P., R. E. Casu, J. M. Peters, C. M. Dimmock, K. R. Gale, R. Boese, and I. G. Wright. 1993. Characterisation of a family of multi-copy genes encoding rhoptry protein homologues in Babesia bovis, Babesia ovis and Babesia canis. Mol. Biochem. Parasitol. 57:181-192.
14. Dalrymple, B. P., J. M. Peters, R. Bose, and I. G. Wright. 1996. A polymerase chain reaction method for the identification of genes encoding members of the Bv60/p58 family of rhoptry protein homologues in the genus Babesia. Exp. Parasitol. 84:96-100.
15. Forsthuber, T., H. C. Yip, and P. V. Lehmann. 1996. Induction of Th1 and Th2 immunity in neonatal mice. Science 271:1728-1730.
16. Goff, W. L., W. C. Davis, G. H. Palmer, T. F. McElwain, W. C. Johnson, J. F. Bailey, and T. C. McGuire. 1988. Identification of Babesia bovis merozoite surface antigens by using bovine sera and monoclonal antibodies. Infect. Immun. 56:2363-2368.
17. Goff, W. L., W. C. Johnson, S. M. Parish, G. M. Barrington, W. Tuo, and R. A. Valdez. 2001. The age-related immunity in cattle to Babesia bovis infection involves the rapid induction of interleukin-12, interferon-γ, and inducible nitric oxide synthase mRNA expression in the spleen. Parasite Immunol. 23:463-471.
18. Hines, S. A., T. F. McElwain, G. M. Buening, and G. H. Palmer. 1989. Molecular characterization of Babesia bovis merozoite surface proteins bearing epitopes immunodominant in protected cattle. Mol. Biochem. Parasitol. 37:1-9.
19. Hines, S. A., G. H. Palmer, D. P. Jasmer, T. C. McGuire, and T. F. McElwain. 1992. Neutralization-sensitive merozoite surface antigens of Babesia bovis encoded by members of a polymorphic gene family. Mol. Biochem. Parasitol. 55:85-94.
20. Homer, M. J., I. Aguilar-Delfin; S. R. Telford III, P. J. Krause, and D. H. Persing. 2000. Babesiosis. Clin. Microbiol. Rev. 13:451-469.
21. Kiemtrup, A. M., and P. A. Conrad. 2000. Human babesiosis: an emerging tick-borne disease. Int. J. Parasitol. 30:1323-1337.
22. McElwain, T. F., L. E. Perryman, W. C. Davis, and T. C. McGuire. 1987. Antibodies define multiple proteins with epitopes exposed on the surface of live Babesia bigemina merozoites. J. Immunol. 138:2298-2304.
23. McElwain, T. F., L. E. Perryman, A. J. Musoke, and T. C. McGuire. 1991. Molecular characterization and immunogenicity of neutralization-sensitive Babesia bigemina merozoite surface proteins. Mol. Biochem. Parasitol. 47:213-222.
24. Mosqueda, J., T. F. McElwain, and G. H. Palmer. 2002. Babesia bovis merozoite surface antigen 2 proteins are expressed on the merozoite and sporozoite surface, and specific antibodies inhibit attachment and invasion of erythrocytes. Infect. Immun. 70:6448-6455.
25. Mosqueda, J., T. F. McElwain, D. Stiller, and G. H. Palmer. 2002. Babesia bovis merozoite surface antigen 1 and rhoptry-associated protein 1 are expressed in sporozoites, and specific antibodies inhibit sporozoite attachment to erythrocytes. Infect. Immun. 70:1599-1603.
26. +-T-lymphocyte responses in B. bovis-immune individuals are located in the amino-terminal domain. Infect. Immun. 70:2039-2048.
27. Persing, D. H., R. N. Coler, M. J. Lacy, D. A. Johnson, J. R. Baldrige, R. M. Hershberg, and S. G. Reed. 2002. Taking toll: lipid A mimetics as adjuvants and immunomodulators. Trends Microbiol. 10:S32-S37.
28. Ramasamy, R. 1998. Molecular basis for evasion of host immunity and pathogenesis in malaria. Biochim. Biophys. Acta 1406:10-27.
29. + T helper lymphocyte responses against Babesia bigemina rhoptry-associated protein-1. Infect. Immun. 64:2079-2087.
30. Schetters, T. P. M., and S. Montenegro-James. 1995. Vaccines against babesiosis using soluble parasite antigens. Parasitol. Today 11:456-462.
31. Schofield, L. 1991. On the function of repetitive domains in protein antigens of Plasmodium and other eukaryotic parasites. Parasitol. Today 7:99-105.
32. Shoda, L. K. M., J. Florin-Christensen, M. Florin-Christensen, G. H. Palmer, and W. C. Brown. 2000. Babesia bovis-stimulated macrophages express interleukin-1β, interleukin-12, tumor necrosis factor alpha, and nitric oxide and inhibit parasite replication in vitro. Infect. Immun. 68:5139-5145.
33. Skuce, P. J., T. R. Mallon, and S. B. Taylor. 1996. Molecular cloning of a putative rhoptry protein homologue from Babesia divergens. Mol. Biochem. Parasitol. 77:99-102.
34. Suarez, C. E., T. F. McElwain, E. B. Stephens, V. S. Misha, and G. H. Palmer. 1991. Sequence conservation among merozoite apical complex proteins of Babesia bovis, Babesia bigemina and other apicomplexa. Mol. Biochem. Parasitol. 49:329-332.
35. Suarez, C. E., G. H. Palmer, S. A. Hines, and T. F. McElwain. 1993. Immunogenic B-cell epitopes of Babesia bovis rhoptry-associated protein 1 are distinct from sequences conserved between species. Infect. Immun. 61:3511-3517.
36. Suarez, C. E., G. H. Palmer, I. Hötzel, and T. F. McElwain. 1998. Structure, sequence, and transcriptional analysis of the Babesia bovis rap-1 multigene locus. Mol. Biochem. Parasitol. 93:215-224.
37. Suarez, C. E., G. H. Palmer, D. P. Jasmer, S. A. Hines, L. E. Perryman, and T. F. McElwain. 1991. Characterization of the gene encoding a 60-kilodalton Babesia bovis merozoite protein with conserved and surface exposed epitopes. Mol. Biochem. Parasitol. 46:45-52.
38. Suarez, C. E., S. M. Thompson, T. F. McElwain, S. A. Hines, and G. H. Palmer. 1994. Conservation of oligopeptide motifs in rhoptry protein from different genera of erythroparasitic protozoa. Exp. Parasitol. 78:246-251.
39. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 12:251-276.
40. Trueman, K. F., and G. W. Blight. 1978. The effect of age on resistance of cattle to Babesia bovis. Aust. Vet. J. 54:301-305.
41. Tuo, W., G. H. Palmer, T. C. McGuire, D. Zhu, and W. C. Brown. 2000. Interleukin-12 as an adjuvant promotes immunoglobulin G and type 1 cytokine recall responses to major surface protein 2 of the ehrlichial pathogen Anaplasma marginale. Infect. Immun. 68:270-280.
42. van Eijk, M. J. T., J. A. Stewart-Haynes, and H. A. Lewin. 1992. Extensive polymorphism of the BoLA-DRB3 gene distinguished by PCR-RFLP. Anim. Genet. 23:483-496.
43. Wright, I. G., R. Casu, M. A. Commins, B. P. Dalrymple, K. R. Gale, B. V. Goodger, P. W. Riddles, D. J. Waltisbuhl, I. Abetz, D. A. Berrie, Y. Bowles, C. Dimmock, T. Hayes, H. Kalnins, G. Leatch, R. McCrae, P. E. Montague, I. T. Nisbet, F. Parrodi, J. M. Peters, P. C. Scheiwe, W. Smith, K. Rode-Bramanis, and M. A. White. 1992. The development of a recombinant Babesia vaccine. Vet. Parasitol. 44:3-13.
44. Wright, I. G., B. V. Goodger, and I. A. Clark. 1988. Immunopathophysiology of Babesia bovis and Plasmodium falciparum infections. Parasitol. Today 4:214-218.
45. Yokoyama, N., B. Suthisak, H. Hirata, T. Matsuo, N. Inoue, C. Sugimoto, and I. Igarashi. 2002. Cellular localization of Babesia bovis merozoite rhoptry-associated protein-1 and its erythrocyte-binding activity. Infect. Immun. 70:5822-5826.
46. Zhang, Y., G. H. Palmer, J. R. Abbott, C. J. Howard, J. C. Hope, and W. C. Brown. 2003. CpG ODN 2006 and IL-12 are comparable for priming Th1 lymphocyte and IgG responses in cattle immunized with a rickettsial outer membrane protein in alum. Vaccine 21:3307-3318.