Mitochondria and lipodystrophy: Where are we now?

Antiviral Therapy

Volumn 8, Issue 4, 2003, Pages 261-263

  Gerschenson, Mariana ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CD4 ANTIGEN; CD8 ANTIGEN; CYTOCHROME C OXIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYPEPTIDE; POLYPEPTIDE OF OXIDATIVE PHOSPHORYLATION; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NUCLEAR RESPIRATORY FACTOR 1; TRANSCRIPTION FACTOR NUCLEAR RESPIRATORY FACTOR 2; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; UNCOUPLING PROTEIN 4;

ADIPOSE TISSUE; APOPTOSIS; CELL ORGANELLE; COHORT ANALYSIS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EDITORIAL; ENERGY METABOLISM; ENZYME ACTIVITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPOATROPHY; LIPODYSTROPHY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MONONUCLEAR CELL; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DNA, MITOCHONDRIAL; HIV INFECTIONS; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; MITOCHONDRIA;

EID: 0041823260     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (24)

1. Kopecky J, Rossmeisl M, Flachs P, Bardova K & Brauner P. Mitochondrial uncoupling and lipid metabolism in adipocytes. Biochemical Society Transactions 2001; 29:791-797.
2. Dagan T, Sable C, Bray J & Gerschenson M. Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities: what is the evidence. Mitochondrion 2002; 1:397-412.
3. Wallace DC. Animal models for mitochondrial disease. Methods in Molecular Biology 2002; 197:3-54.
4. Kakuda TN. Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity. Clinical Therapeutics 2000; 22:685-708.
5. Lewis W, Gonzalez B, Chomyn A & Papoian T. Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria. Journal of Clinical Investigation 1992; 89:1354-1360.
6. Gerschenson M, Nguyen VT, St Claire MC, Harbaugh SW, Harbaugh JW, Proia LA & Poirier MC. Chronic stavudine exposure induces hepatic mitochondrial toxicity in adult Erythrocebus patas monkeys. Journal of Human Virology 2001; 4:335-342.
7. Shoffner JM. Maternal inheritance and the evaluation of oxidative phosphorylation diseases. Lancet 1996; 348:1283-1288,
8. Shoffner JM. An introduction: oxidative phosphorylation diseases. Seminars in Neurology 2001; 21:237-250.
9. Cote HC, Brumme ZL, Craib KJ, Alexander CS, Wynhoven B, Ting L, Wong H, Harris M, Harrigan PR, O'Shaughnessy MV & Montaner JS. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. New England Journal of Medicine 2002; 346:811-820.
10. Cherry CL, Gahan ME, McArthur JC, Lewin SR, Hoy JF & Wesselingh SL. Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat. Journal of Acquired Immune Deficiency Syndromes 2002; 30:271-277.
11. Leeson CR, Leeson TS & Paparo AA. Textbook of Histology. 4th edn 1985. Philadelphia: W.B. Saunders Company.
12. Miró Ò, López S, Pedrol E, Rodrí guez-Santiago B, Martínez E, Soler A, Milinkovic A, Casademont J, Nunes V, Gatell JM & Cardellach F. Mitochondrial DNA depletion and respiratory chain enzyme deficiencies are present in peripheral blood mononuclear cells of HIV-infected patients with HAART-related lipodystrophy. Antiviral Therapy 2003; 8:333-338.
13. Cossarizza A, Riva A, Pinti M, Ammannato S, Fedeli P, Mussini C, Esposito R & Galli M. Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy. Antiviral Therapy 2003; 8:315-321.
14. Shikuma CM & Shiramizu B. Mitochondrial toxicity associated with nucleoside reverse transcriptase inhibitor therapy. Current Infectious Disease Reports 2001; 3:553-560.
15. Walker UA, Bickel M, Lutke Volksbeck SI, Ketelsen UP, Schofer H, Setzer B, Venhoff N, Rickerts V & Staszewski S. Evidence of nucleoside analogue reverse transcriptase inhibitor-associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients. Journal of Acquired Immune Deficiency Syndromes 2002; 29:117-121.
16. Rolfe DF, Hulbert AJ & Brand MD. Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat. Biochimica et Biophysica Acta 1994; 1188:405-416.
17. Erlanson-Albertsson C. Uncoupling proteins - a new family of proteins with unknown function. Nutritional Neuroscience 2002; 5:1-11.
18. Hagen T & Vidal-Puig A. Mitochondrial uncoupling proteins in human physiology and disease. Minerva Medica 2002; 93:41-57.
19. Lowell BB & Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature 2000; 404:652-660.
20. Jezek P. Possible physiological roles of mitochondrial uncoupling proteins - UCPN. International Journal of Biochemistry & Cell Biology 2002; 34:1190-1206.
21. Puigserver P, Wu Z, Park CW, Graves R, Wright M & Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92:829-839.
22. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC & Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98:115-124.
23. Andersson U & Scarpulla RC. Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Molecular & Cellular Biology 2001; 21:3738-3749.
24. Pace CS, Martin AM, Hammond EL, Mamotte CD, Nolan DA & Mallal SA. Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antiviral Therapy 2003; 8:323-331.