Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content

Diabetes

Volumn 52, Issue 9, 2003, Pages 2221-2226

  Lerín, Carlos ^a   Montell, Eulàlia ^a   Nolasco, Teresa ^a   Clark, Cathy ^b   Brady, Matthew J ^c   Newgard, Christopher B ^b   Gómez Foix, Anna M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; EXERCISE; GENE DELETION; GENE FUNCTION; GENE MUTATION; GENE TARGETING; GLYCOGEN METABOLISM; GLYCOGEN SYNTHESIS; GLYCOGENOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; MEMBRANE BINDING; MUSCLE CELL; MUSCLE CONTRACTION; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; SARCOPLASMIC RETICULUM; SEQUENCE ANALYSIS;

CELLS, CULTURED; CYCLIC AMP; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; HUMANS; HYDROLYSIS; MUSCLE FIBERS; MUSCLE, SKELETAL; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN STRUCTURE, TERTIARY;

EID: 0041820144     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.9.2221     Document Type: Article

References (30)

1. Cohen PTW: Protein phosphatase 1-targeted in many directions. J Cell Sci 115:241-256, 2002
2. Tang PM, Bondor JA, Swidenck KM, DePaoli-Roach AA: Molecular cloning and expression of the regulatory (RGL) subunit of glycogen-associated protein phosphatase. J Biol Chem 266:15782-15789, 1991
3. L)-subunit of protein phosphatase-1. FEBS Lett 375:294-298, 1995
4. Printen JA, Brady MJ, Saltiel AR: PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science 275:1475-1478, 1997
5. Armstrong CG, Browne GJ, Cohen P, Cohen PTW: PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1. FEBS Lett 418:210-214, 1997
6. Newgard CB, Brady MJ, O'Doherty RM, Saltiel AR: Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes 49:1967-1977, 2000
7. Wu J, Liu J, Thompson I, Oliver CJ, Shenolikar S, Brautigan DL: A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. FEBS Lett 439:185-191, 1998
8. Zhao S, Lee EY: A protein phosphatase-1-binding motif identified by the panning of a random peptide display library. J Biol Chem 272:28368-28372, 1997
9. Bak JF, Pedersen O: Exercise enhanced activation of glycogen synthase in human skeletal muscle. Am J Physiol 259:E957-E963, 1992
10. Bonen A, Homonko DA: Effects of exercise and glycogen depletion on glyconeogenesis in muscle. J Appl Physiol 76:1753-1758, 1994
11. Laurent D, Hundal RS, Dresner A, Price TB, Vogel SM, Petersen KF, Shulman GI: Mechanism of muscle glycogen autoregulation in humans. Am J Physiol 278:E663-E668, 2000
12. Nielsen JN, Derave W, Kristiansen S, Ralston E, Ploug T, Richter EA: Glycogen synthase localization and activity in rat skeletal muscle is strongly dependent on glycogen content. J Physiol 531:757-769, 2001
13. Liu J, Brautigan DL: Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. J Biol Chem 275:26074-26081, 2000
14. M) is essential for activation of glycogen synthase by exercise. J Biol Chem 276:39959-39967, 2001
15. Walker KS, Watt PW, Cohen P: Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo. FEBS Lett 466:121-124, 2000
16. Friden J, Seger J, Ekblom B: Topographical localization of muscle glycogen: an ultrahistochemical study in human vastus lateralis. Acta Physiol Scand 125:381-391, 1989
17. Savage D, Agostini M, Barroso I, Gurnell M, Luan J, Meirhaeghe A, Harding AH, Ihrke G, Rajanayagam O, Soos MA, George S, Berger D, Thomas EL, Bell JD, Meeran K, Ross RJ, Vidal-Puig A, Wareham NJ, O'Rahilly S, Chatterjee VK, Schafer AJ: Digenic inheritance of severe insulin resistance in a human pedigree. Nat Genet 31:379-384, 2002
18. Dent P, Lavoinne A, Nakielny A, Caudwell FB, Watt P, Cohen P: The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature 348:302-308, 1990
19. GL. Mol Cell Bio 21:2683-2694, 2001
20. Nakielny S, Campbell DG, Cohen P: The molecular mechanism by which adrenalin inhibits glycogen synthesis. Eur J Biochem 199:713-722, 1991
21. Askanas V, Engel WK: Cultured normal and genetically abnormal human muscle. In Handbook of Clinical Neurology: Myophaties. Vol. 18. Rowland LP, DiMauro S, Eds. North Holland, Amsterdam, 1992, p. 85-116
22. M/RGl) expressed in hepatocytes. J Biol Chem 275:26396-26403, 2000
23. Yang R, Cao L, Gasa R, Brady MJ, Sherry AD, Newgard CB: Glycogen-targeting subunits and glucokinase differently affect pathways of glycogen metabolism and their regulation in hepatocytes. J Biol Chem 277:1514-1523, 2002
24. Berman HK, O'Doherty RM, Anderson P, Newgard CB: Overexpression of protein targeted to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms. J Biol Chem 273:26421-26425, 1998
25. Herz J, Gerard RD: Adenovirus-mediated transfer of low density-lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci U S A 90:2812-2816, 1993
26. Gilboe DP, Larson KL, Nuttall FQ: Radioactive method for the assay of glycogen phosphorylases. Anal Biochem 47:20-27, 1972
27. Thomas JA, Schlender KK, Lamer J: A rapid filter paper assay for UDP-glucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose. Anal Biochem 25:486-499, 1968
28. Montell E, Arias A, Gómez-Foix AM: Glycogen depletion rather than glucose 6-P increments controls early glycogen recovery in human cultured muscle. Am J Physiol 45:R1489-R1495, 1999
29. Lerín C, Montell E, Berman HK, Newgard CB, Gomez-Foix AM: Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels. J Biol Chem 275:39991-39995, 2000
30. Zhang W, DePaoli-Roach AA, Roach PJ: Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase. Arch Biochem Biophys 304:219-225, 1993