Effects of peripheral CCK receptor blockade on food intake in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 285, Issue 2 54-2, 2003, Pages

  Reidelberger, Roger D ^a,b,d   Castellanos, Daniel A ^a,b   Hulce, Martin ^c  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CREIGHTON UNIVERSITY   (United States)

^d NONE   (United States)

Author keywords

A 70104; Devazepide; Receptor antagonist; Satiety

Indexed keywords

A 70104; CHOLECYSTOKININ; CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEVAZEPIDE; N (3 QUINOLYLCARBONYL) DEXTRO GLUTAMIC ACID ALPHA DIPENTYLAMIDE; PEPTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG PENETRATION; FOOD INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SATIETY;

EID: 0041808024     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00176.2003     Document Type: Article

References (45)

1. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
2. Arnelo U, Permert J, Larsson J, Reidelberger RD, Arnelo C, and Adrian TE. Chronic low dose islet amyloid polypeptide infusion reduces food intake, but does not influence glucose metabolism, in unrestrained conscious rats: studies using a novel aortic catheterization technique. Endocrinology 138: 4081-4085, 1997.
3. Asin KE, Bednarz L, Nikkel AL, Gore PA Jr, Montana WE, Cullen MJ, Shiosaki K, Craig R, and Nadzan AM. Behavioral effects of A71623, a highly selective CCK-A agonist tetrapeptide. Am J Physiol Regul Integr Comp Physiol 263: R125-R135, 1992.
4. Asin KE, Bednarz L, Nikkel AL, Gore PA Jr, and Nadzan AM. A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol Biochem Behav 42: 699-704, 1992.
5. Baldwin BA, de la Riva C, and Gerskowitch VP. Effect of a novel CCKA receptor antagonist (2-NAP) on the reduction in food intake produced by CCK in pigs. Physiol Behav 55: 175-179, 1994.
6. Baldwin BA, Parrott RF, and Ebenezer IS. Food for thought: a critique on the hypothesis that endogenous cholecystokinin acts as a physiological satiety factor. Prog Neurobiol 55: 477-507, 1998.
7. Beglinger C, Degen L, Matzinger D, D'Amato M, and Drewe J. Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans. Am J Physiol Regul Integr Comp Physiol 280: R1149-R1154, 2001.
8. Berthoud HR and Patterson LM. Anatomical relationship between vagal afferent fibers and CCK-immunoreactive enteroendocrine cells in the rat small intestinal mucosa. Acta Anat (Basel) 156: 123-131, 1996.
9. Blevins JE, Stanley BG, and Reidelberger RD. Brain regions where cholecystokinin suppresses feeding in rats. Brain Res 860: 1-10, 2000.
10. Britton DR, Yahiro L, Cullen MJ, Kerwin JF Jr, Kopecka H, and Nadzan AM. Centrally administered CCK-8 suppresses activity in mice by a "peripheral-type" CCK receptor. Pharmacol Biochem Behav 34: 779-783, 1989.
11. Choi BR, Palmquist DL, and Allen MS. Cholecystokinin mediates depression of feed intake in dairy cattle fed high fat diets. Domest Anim Endocrinol 19: 159-175, 2000.
12. Covasa M and Forbes JM. Effects of the CCK receptor antagonist MK-329 on food intake in broiler chickens. Pharmacol Biochem Behav 48: 479-486, 1994.
13. Davison JS and Clarke GD. Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechanoreceptors. Am J Physiol Gastrointest Liver Physiol 255: G55-G61, 1988.
14. De Fanti BA, Backus RC, Hamilton JS, Gietzen DW, and Horwitz BA. Lean (Fa/Fa) but not obese (fa/fa) Zucker rats release cholecystokinin at PVN after a gavaged meal. Am J Physiol Endocrinol Metab 275: E1-E5, 1998.
15. Della-Fera MA, Baile CA, Schneider BS, and Grinker JA. Cholecystokinin antibody injected in cerebral ventricles stimulates feeding in sheep. Science 212: 687-689, 1981.
16. Eastwood C, Maubach K, Kirkup AJ, and Grundy D. The role of endogenous cholecystokinin in the sensory transduction of luminal nutrient signals in the rat jejunum. Neurosci Lett 254: 145-148, 1998.
17. Ebenezer IS. Effects of intracerebroventricular administration of the CCK(1) receptor antagonist devazepide on food intake in rats. Eur J Pharmacol 441: 79-82, 2002.
18. Ebenezer IS. The effects of a peripherally acting cholecystokinin(1) receptor antagonist on food intake in rats: implications for the cholecystokinin-satiety hypothesis. Eur J Pharmacol 461: 113-118, 2003.
19. Ebenezer IS and Baldwin BA. 2-Naphthalenesulphanyl-L-aspartyl-2-(phenethyl) amide (2-NAP) and food intake in rats: evidence that endogenous peripheral CCK does not play a major role as a satiety factor. Br J Pharmacol 116: 2371-2374, 1995.
20. Ebenezer IS, de la Riva C, and Baldwin BA. Effects of the CCK receptor antagonist MK-329 on food intake in pigs. Physiol Behav 47: 145-148, 1990.
21. Ebenezer IS and Parrott RF. A70104 and food intake in pigs: implication for the CCK "satiety" hypothesis. Neuroreport 4: 495-498, 1993.
22. Hull RA, Shankley NP, Harper EA, Gerkowitch VP, and Black JW. 2-Naphthalenesulphonyl L-aspartyl-(2-phenethyl) amide (2-NAP)-a selective cholecystokinin CCKA-receptor antagonist. Br J Pharmacol 108: 734-740, 1993.
23. Kerwin JF Jr, Nadzan AM, Kopecka H, Lin CW, Miller T, Witte D, and Burt S. Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists. J Med Chem 32: 739-742, 1989.
24. Lal S, Kirkup AJ, Brunsden AM, Thompson DG, and Grundy D. Vagal afferent responses to fatty acids of different chain length in the rat. Am J Physiol Gastrointest Liver Physiol 281: G907-G915, 2001.
25. 3H]pentyl-N-(3-quinolinoyl)glutamic acid amide. J Label Compd Radiopharm 43: 77-99, 2000.
26. Meddings JB, Scott RB, and Fick GH. Analysis and comparison of sigmoidal curves: application to dose-response data. Am J Physiol Gastrointest Liver Physiol 257: G982-G989, 1989.
27. Moran TH, Ameglio PJ, Peyton HJ, Schwartz GJ, and McHugh PR. Blockade of type A, but not type B, CCK receptors postpones satiety in rhesus monkeys. Am J Physiol Regul Integr Comp Physiol 265: R620-R624, 1993.
28. Moran TH, Norgren R, Crosby RJ, and McHugh PR. Central and peripheral vagal transport of cholecystokinin binding sites occurs in afferent fibers. Brain Res 526: 95-102, 1990.
29. Pullen RG and Hodgson OJ. Penetration of diazepam and the non-peptide CCK antagonist, L-364,718, into rat brain. J Pharm Pharmacol 39: 863-864, 1987.
30. Reidelberger RD. Abdominal vagal mediation of the satiety effects of exogenous and endogenous cholecystokinin in rats. Am J Physiol Regul Integr Comp Physiol 263: R1354-R1358, 1992.
31. Reidelberger RD, Arnelo U, Granqvist L, and Permert J. Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats. Am J Physiol Regul Integr Comp Physiol 280: R605-R611, 2001.
32. Reidelberger RD, Heimann D, Kelsey L, and Hulce M. Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats. Am J Physiol Regul Integr Comp Physiol 284: R389-R398, 2003.
33. Reidelberger RD, Kelsey L, Heimann D, and Hulce M. Effects of peripheral CCK receptor blockade on gastric emptying in rats. Am J Physiol Regul Integr Comp Physiol 284: R66-R75, 2003.
34. Reidelberger RD and O'Rourke MF. Potent cholecystokinin antagonist L-364718 stimulates food intake in rats. Am J Physiol Regul Integr Comp Physiol 257: R1512-R1518, 1989.
35. Reidelberger RD, Varga G, Liehr RM, Castellanos DA, Rosenquist GL, Wong HC, and Walsh JH. Cholecystokinin suppresses food intake by a nonendocrine mechanism in rats. Am J Physiol Regul Integr Comp Physiol 267: R901-R908, 1994.
36. Ritter RC, Covasa M, and Matson CA. Cholecystokinin: proofs and prospects for involvement in control of food intake and body weight. Neuropeptides 33: 387-399, 1999.
37. Ritter RC and Malbasa Z. CCK-A receptor antagonist increases food intake in capsaicin-treated rats. Soc Neurosci Abstr 21: 460, 1995.
38. Schick RR, Reilly WM, Roddy DR, Yaksh TL, and Go VL. Neuronal cholecystokinin-like immunoreactivity is postprandially released from primate hypothalamus. Brain Res 418: 20-26, 1987.
39. Schick RR, Schusdziarra V, Yaksh TL, and Go VL. Brain regions where cholecystokinin exerts its effect on satiety. Ann NY Acad Sci 713: 242-254, 1994.
40. Walsh JH. Gastrointestinal hormones. In: Physiology of the Gastrointestinal Tract, edited by Johnson LR. New York: Raven, 1987, p. 181-253.
41. Woltman T, Castellanos D, and Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic acid in rats. Am J Physiol Regul Integr Comp Physiol 269: R1420-R1433, 1995.
42. Woltman T and Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of glucose in rats. Am J Physiol Regul Integr Comp Physiol 271: R1521-R1528, 1996.
43. Woltman T and Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of peptone in rats. Am J Physiol Regul Integr Comp Physiol 276: R1701-R1709, 1999.
44. Woltman TA, Hulce M, and Reidelberger RD. Relative blood-brain barrier permeabilities of the cholecystokinin receptor antagonists devazepide and A-65186 in rats. J Pharm Pharmacol 51: 917-920, 1999.
45. Zarbin MA, Wamsley JK, Innis RB, and Kuhar MJ. Cholecystokinin receptors: presence and axonal flow in the rat vagus nerve. Life Sci 29: 697-705, 1981.