Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats

American Journal of Physiology

Volumn 280, Issue 3 PART 2, 2001, Pages

  Reidelberger, Roger D ^a   Arnelo, Urban ^b   Granqvist, Lars ^b   Permert, Johan ^b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b NONE

Author keywords

Efficacy; Intravenous; Meal patterns; Potency; Satiety; Stomach

Indexed keywords

AMYLIN; CHOLECYSTOKININ;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; EATING HABIT; FOOD INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SATIETY; SIGNAL TRANSDUCTION; STOMACH EMPTYING;

AMYLOID; ANIMALS; EATING; GASTRIC EMPTYING; GASTROINTESTINAL AGENTS; INFUSIONS, INTRAVENOUS; KINETICS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SINCALIDE;

EID: 0035019741     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2001.280.3.r605     Document Type: Review

References (35)

1. Arnelo U, Permert J, Adrian TE, Larsson J, Westermark P, and Reidelberger RD. Chronic infusion of islet amyloid polypeptide causes anorexia in rats. Am J Physiol Regulatory Integrative Comp Physiol 271: R1654-R1659, 1996.
2. Arnelo U, Reidelberger R, Adrian TE, Larsson J, and Permert J. Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in rats. Am J Physiol Regulatory Integrative Comp Physiol 275: R1537-R1542, 1998.
3. Asarian L, Eckel LA, and Geary N. Behaviorally specific inhibition of sham feeding by amylin. Peptides 19: 1711-1718, 1998.
4. Banks WA and Kastin AJ. Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin. Peptides 19: 883-889, 1998.
5. Banks WA, Kastin AJ, Huang W, Jaspan JB, and Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides 17: 305-311, 1996.
6. Banks WA, Kastin AJ, Maness LM, Huang W, and Jaspan JB. Permeability of the blood-brain barrier to amylin. Life Sci 57: 1993-2001, 1995.
7. Bhavsar S, Watkins J, and Young A. Synergy between amylin and cholecystokinin for inhibition of food intake in mice. Physiol Behav 64: 557-561, 1998.
8. Blevins JE, Hamel FG, Fairbairn E, Stanley BG, and Reidelberger RD. Effects of paraventricular nucleus injection of CCK-8 on plasma CCK-8 levels in rats. Brain Res 860: 11-20, 2000.
9. Chance WT, Balasubramaniam A, Zhang FS, Wimalawansa SJ, and Fischer JE. Anorexia following the intrahypothalamic administration of amylin. Brain Res 539: 352-354, 1991.
10. Clementi G, Caruso A, Cutuli VM, de Bernardis E, Prato A, and Amico-Roxas M. Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat. Experientia 52: 677-679, 1996.
11. Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, and Reid KB. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84: 8628-8632, 1987.
12. DeLean A, Munson PJ, and Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol Endocrinol Metab Gastrointest Physiol 235: E97-E102, 1978.
13. Folsch UR, Cantor P, Wilms HM, Schafmayer A, Becker HD, and Creutzfeldt W. Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rats. Gastroenterology 92: 449-458, 1987.
14. Gebre-Medhin S, Mulder H, Pekny M, Westermark G, Tornell J, Westermark P, Sundler F, Ahren B, and Betsholtz C. Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin). Biochem Biophys Res Commun 250: 271-277, 1998.
15. Gedulin BR and Young AA. Hypoglycemia overrides amylin-mediated regulation of gastric emptying in rats. Diabetes 47: 93-97, 1998.
16. Guidobono F, Coluzzi M, Pagani F, Pecile A, and Netti C. Amylin given by central and peripheral routes inhibits acid gastric secretion. Peptides 15: 699-702, 1994.
17. Holzer HH, Turkelson CM, Solomon TE, and Raybould HE. Intestinal lipid inhibits gastric emptying via CCK and a vagal capsaicin-sensitive afferent pathway in rats. Am J Physiol Gastrointest Liver Physiol 267: G625-G629, 1994.
18. Kalogeris TJ, Reidelberger RD, and Mendel VE. Effect of nutrient density and composition of liquid meals on gastric emptying in feeding rats. Am J Physiol Regulatory Integrative Comp Physiol 244: R865-R871, 1983.
19. Kong MF, King P, Macdonald IA, Stubbs TA, Perkins AC, Blackshaw PE, Moyses C, and Tattersall RB. Infusion of pramlintide, a human amylin analog, delays gastric emptying in men with IDDM. Diabetologia 40: 82-88, 1997.
20. Kong MF, Stubbs TA, King P, Macdonald IA, Lambourne JE, Blackshaw PE, Perkins AC, and Tattersall RB. The effect of single doses of pramlintide on gastric emptying of two meals in men with IDDM. Diabetologia 41: 577-583, 1998.
21. Meddings JB, Scott RB, and Fick GH. Analysis and comparison of sigmoidal curves: application to dose-response data. Am J Physiol Gastrointest Liver Physiol 257: G982-G989, 1989.
22. Mulder H, Ekelund M, Ekblad E, and Sundler F. Islet amyloid polypeptide in the gut and pancreas: localization, ontogeny and gut motility effects. Peptides 18: 771-783, 1997.
23. Mulder H, Leckstrom A, Uddman R, Ekblad E, Westermark P, and Sundler F. Islet amyloid polypeptide (amylin) is expressed in sensory neurons. J Neurosci 15: 7625-7632, 1995.
24. Mulder II, Lindh AC, Ekblad E, Westermark P, and Sundler F. Islet amyloid polypeptide is expressed in endocrine cells of the gastric mucosa in the rat and mouse. Gastroenterology 107: 712-719, 1994.
25. Raybould HE. Nutrient tasting and signaling mechanisms in the gut. I. Sensing of lipid by the intestinal mucosa. Am J Physiol Gastrointest Liver Physiol 277: G751-G755, 1999.
26. Reidelberger RD. Cholecystokinin and control of food intake. J Nutr 124: 1327S-1333S, 1994.
27. Reidelberger RD and Solomon TE. Comparative effects of CCK-8 on feeding, sham feeding, and exocrine pancreatic secretion in rats. Am J Physiol Regulatory Integrative Comp Physiol 251: R97-R105, 1986.
28. Rossowski WJ, Jiang N, and Coy DH. Adrenomedullin, amylin, calcitonin gene-related peptide and their fragments are potent inhibitors of gastric acid secretion in rats. Eur J Pharmacol 336: 51-63, 1997.
29. Rushing PA, Hagan MM, Seeley RJ, Lutz TA, and Woods SC. Amylin: a novel action in the brain to reduce body weight. Endocrinology 141: 850-853, 2000.
30. Rushing PA, Lutz TA, Seeley RJ, and Woods SC. Amylin and insulin interact to reduce food intake in rats. Horm Metab Res 32: 62-65, 2000.
31. Sexton PM, Paxinos G, Kenney MA, Wookey PJ, and Beaumont K. In vitro autoradiographic localization of amylin binding sites in rat brain. Neuroscience 62: 553-567, 1994.
32. Westermark P, Wernstedt C, Wilander E, and Sletten K. A novel peptide in the calcitonin gene related family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 140: 827-831, 1986.
33. Woltman T, Castellanos D, and Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic acid in rats. Am J Physiol Regulatory Integrative Comp Physiol 269: R1420-R1433, 1995.
34. Young AA, Gedulin B, Vine W, Percy A, and Rink TJ. Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin. Diabetologia 38: 642-648, 1995.
35. Young AA, Gedulin BR, and Rink TJ. Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7-36) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake. Metabolism 45: 1-3, 1996.