Expression of gastric mucin in the stomachs of two patients with Menetrier's disease: An immunohistochemical study

Journal of Gastroenterology and Hepatology (Australia)

Volumn 18, Issue 7, 2003, Pages 876-879

  Mall, Anwar S ^a   Taylor, Kathryn ^a   Barnard, Rochelle ^a   Dent, David M ^a   Kahn, Delawir ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Menetrier's disease; Mucin; Stomach

Indexed keywords

STOMACH MUCIN;

ADULT; AGED; ARTICLE; CASE REPORT; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MENETRIER DISEASE; MUCUS SECRETION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN VARIANT; STAINING; STOMACH; STOMACH MUCOSA; TISSUE DISTRIBUTION;

EID: 0041701566     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2003.02828.x     Document Type: Article

References (21)

1. Sundt TM III, Compton CC, Malt RA. Menetrier's disease, a trivalent gastropathy. Ann. Surg. 1988; 208: 694-701.
2. Dempsey PJ, Goldenring JR, Soroka CJ et al. Possible role of transforming growth factor alpha in the pathogenesis of Menetrier's Disease: Supportive evidence from human and transgenic mice. Gastroenterology 1992; 103: 1950-63.
3. Kristensen M, Nilsson T. Mucus secretion in hypertrophic, hypersecretory, protein-losing gastropathy. Am. J. Gastroenterol. 1985; 80: 77-81.
4. Mall A, Dent DM, McLeod H, Kahn D, Taylor K, Hickman R. Extraction, isolation and SDS-PAGE analysis of purified gastric mucin in a patient with Menetrier's Disease. A Case Report. Am. J. Gastroenterology 2002; 97: 752-5.
5. Allen A. Structure and function of gastrointestinal mucus. In: Johnson R, eds. Physiology of the Gastrointestinal Tract. New York: Raven Press, 1981.
6. Desseyn J-L, Aubert J-P, Porchet N, Laine A. Evolution of the large secreted gel-forming mucins. Mol. Biol. Evol. 2000; 17: 1175-84.
7. Van Klinken BJW, Dekker J, Buller HA, Einerhand AWC. Mucin gene structure and expression: protection vs adhesion. Am. J. Physiol. 1995; 269: G613-27.
8. Svitacheva N, Davies JR. Mucin biosynthesis and secretion in tracheal epithelial cells in primary culture. Biochem. J. 2001; 353: 23-32.
9. Reis CA, David L, Correa P et al. Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUCSAC, and MUC6) expression. Cancer Res. 1999; 59: 1003-7.
10. Taylor KL, Mall A, Barnard RA, Ho SB, Cruse P. Immunohistochemical detection of gastric mucin in normal and diseased states. Oncol Res. 1998; 10: 465-73.
11. Ho SB, Shekels LL, Toribara NW et al. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res. 1995; 55: 2681-90.
12. Graham RA, Burchell JM, Taylor-Papadimitriou J. The polymorphic epithelial mucin: Potential as an immunogen for a cancer vaccine. Cancer Immunol. Immunother. 1996; 42: 71-80.
13. Devine PL, McKenzie FC, Mucins. Structure, function and association with malignancy. Bioessays 1992; 14: 619-25.
14. De Bolos C, Garrido M, Real FX. MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach. Gastroenterology 1995; 109: 723-34.
15. Mall AS, McLeod HA, Hickman R, Kahn D, Dent D. Fragmentation patterns of mucins in normal and diseased gastric mucosae: a glycoprotein fractionates with gastric mucins purified from mucosal scrapings of cancer and peptic ulcer patients. Digestion 1999; 60: 216-26.
16. Mall AS, McLeod H, Hickman R, Kahn D, Dent D. The fragmentation of MUC5AC gastric mucin in diseased states. S. Afr. J. Sci. 1999; 55: 59-60.
17. Mall A, McConney Z, Lotz Z et al. Increased fragmentation of MUCSAC mucins in gastric juice of patients with ulceration and carcinoma. S. Afr. J. Sci. 2000; 96: 39-43.
18. Bradshaw E, Harington JS. The changing pattern of cancer mortality in South Africa, 1949-69. S. Afr. Med. J. 1975; 49: 919-25.
19. Wyndham CH. Comparison and ranking of cancer mortality rates in the various populations of the RSA in 1970. S. Afr. Med. J. 1985; 6: 586-7.
20. Sitas F, Isaacson M. Histologically diagnosed cancer in South Africa, 1987. S. Afr. Med. J. 1992; 81: 565-8.
21. Geist M, Fich A, Mogle P. Menetrier's disease: Evolution of disease under histamine-2 receptor antagonists. Am. J. Gastroenterol. 1992; 87: 648-50.