Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes: Increased bilirubin and uroporphyrinogen oxidation in vitro

Biochemical Pharmacology

Volumn 66, Issue 3, 2003, Pages 405-414

  Pons, Nicoletta ^a   Pipino, Sandra ^a,c   De Matteis, Francesco ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c GSK   (Italy)

Author keywords

Bilirubin degradation; CYP102; CYP1A1; CYP1A2; Perfluorododecanoic acid; Polyhalogenated biphenyls; Uroporphyrinogen oxidation

Indexed keywords

3,4,3'4' TETRACHLOROBIPHENYL; BACTERIAL ENZYME; BILIRUBIN; BIPHENYL DERIVATIVE; CYTOCHROME P450 102; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DRUG ANALOG; ENZYME; LAURIC ACID; LAURIC ACID DERIVATIVE; PERFLUORODODECANOIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; UROPORPHYRINOGEN;

ARTICLE; BACTERIUM; BINDING AFFINITY; CHEMICAL INTERACTION; DRUG POTENCY; DRUG SCREENING; HALOGENATION; IN VITRO STUDY; MAMMAL; MEASUREMENT; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; STIMULATION; STOICHIOMETRY;

EID: 0041695664     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00284-3     Document Type: Article

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