Potential of statins for the treatment of multiple sclerosis

Lancet Neurology

Volumn 2, Issue 1, 2003, Pages 9-10

  Baker, David ^a   Adamson, Peter ^b   Greenwood, John ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CYTOKINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON BETA SERINE; MEVINOLIN; PYROPHOSPHORIC ACID DERIVATIVE; SIMVASTATIN; IMMUNOLOGICAL ADJUVANT;

ALLERGIC ENCEPHALOMYELITIS; CLINICAL TRIAL; CYTOKINE RELEASE; DRUG APPROVAL; DRUG EFFECT; DRUG EFFICACY; HUMAN; IMMUNOMODULATION; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SIDE EFFECT; TH1 CELL; TH2 CELL; TREATMENT OUTCOME; ARTICLE; AUTOIMMUNE DISEASE; CENTRAL NERVOUS SYSTEM; LEUKOCYTE; PATHOLOGY;

ADJUVANTS, IMMUNOLOGIC; AUTOIMMUNE DISEASES; CENTRAL NERVOUS SYSTEM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKOCYTES; MULTIPLE SCLEROSIS;

EID: 0041677693     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(03)00256-4     Document Type: Letter

References (5)

1. Stanislaus R., Singh A.K., Singh I. Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis. J Neurosci Res. 66:2001;155-162.
2. Neuhaus O., Strasser-Fuchs S., Fazekas F., et al. Statins as immunomodulators. Comparison with interferon-ß1b in MS. Neurology. 59:2002;990-997.
3. Youssef S., Stuve O., Patarroyo J.C., et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature. 420:2002;78-84.
4. Walters C.E., Pryce G., Baker D., Sebti S.M., Greenwood J., Adamson P. Inhibition of rho GTPases with protein prenyl transferase inhibitors prevent leukocyte recruitment to the CNS and attenuate clinical signs of disease in an animal model of multiple sclerosis. J Immunol. 168:2002;4087-4094.
5. Kwak B., Mulhaupt F., Myit S., Mach F. Statins as a newly recognised type of immunomodulator. Nat Med. 6:2000;1399-1402.