Single histidine residue in head-group region is sufficient to impart remarkable gene transfection properties to cationic lipids: Evidence for histidine-mediated membrane fusion at acidic pH

Gene Therapy

Volumn 10, Issue 15, 2003, Pages 1206-1215

  Kumar, V V ^a   Pichon, C ^b   Refregiers, M ^b   Guerin, B ^b   Midoux, P ^b   Chaudhuri, A ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

Author keywords

Cationic lipids; Gene transfer; Liposomes

Indexed keywords

AMPHOPHILE; CATION; CHOLESTEROL; HISTIDINE; HISTIDINE(N,N DI N HEXADECYLAMINE N METHYL)ETHYLAMIDE; HISTIDINE(N,N DI N HEXADECYLAMINE)ETHYLAMIDE; LIPID; LIPOSOME; LUCIFERASE; PLASMID DNA; POLYLYSINE; POLYMER; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CELL STRAIN HEPG2; CHEMICAL STRUCTURE; CONTROLLED STUDY; COVALENT BOND; CYTOSOL; ENDOSOME; ENERGY TRANSFER; EXPRESSION VECTOR; FLUORESCENCE; GENE EXPRESSION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; MEMBRANE FUSION; NONVIRAL GENE DELIVERY SYSTEM; PH; PRIORITY JOURNAL; PROMOTER REGION; SYNTHESIS; TRANSGENE;

CELL LINE; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; LIPOSOMES; MEMBRANE FUSION; TRANSFECTION;

BACTERIA (MICROORGANISMS); VECTORS;

EID: 0041672210     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301979     Document Type: Article

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