Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans

Xenobiotica

Volumn 26, Issue 8, 1996, Pages 839-851

  Lave, Th ^a   Dupin, S ^a   Schmitt, M ^a   Kapps, M ^a   Meyer, J ^a   Morgenroth, B ^a   Chou, R C ^a   Jaeck, D ^b   Coassolo, Ph ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b HÔPITAL DE HAUTEPIERRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE INHIBITOR; TOLCAPONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DOG; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; LIVER CELL; MATHEMATICAL MODEL; METABOLIC CLEARANCE RATE; METABOLIC RATE; NONHUMAN; PLASMA CLEARANCE; PREDICTION; RABBIT; RAT; SPECIES DIFFERENCE; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0029799630     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609046754     Document Type: Article

References (21)

1. BOXENBAUM, B., and D'SOUZA, R. W., 1990, Interspecies pharmacokinetic scaling, biological design and neoteny. In Advances in Drug Research, ed. B. Testa (London: Academic Press Limited), pp. 139-196.
2. BOXENBAUM, H., and FERTIG, J. B., 1984, Scaling of antipyrine intrinsic clearance of unbound drug in 15 mammalian species. European Journal of Drug Metabolism and Pharmacokinetics, 9, 177-183.
3. DAVIES, B., and MORRIS, T., 1993, Physiological parameters in laboratory animals and humans. Pharmaceutical Research, 10, 1093-1095.
4. DEDRICK, R. L., BISCHOFF, K. B., and ZAHARKO, D. S., 1970, Interspecies correlation of plasma concentrations of methotrexate (NSC-740). Cancer Chemotherapy Reports, 54, 95-101.
5. EFTHYMIOPOULOS, C., BATTAGLIA, R., and STROLIN-BENEDETTI, M., 1991, Animal pharmacokinetics and interspecies scaling of FCE 22010, a penem antibiotic. Journal of Antimicrobial Chemotherapy, 27, 517-526.
6. HEINZEL, G., WOBSZCZAK, R., and THOMANN, P., 1993, Pharmacokinetic and Pharmacodynamic Data Analysis System for the PC (Stuttgart: Gustav Fischer).
7. HOENER, B. A., 1994, Predicting the hepatic clearance of xenobiotics in humans from in vitro data. Biopharmaceutics and Drug Disposition, 15, 295-304.
8. HOUSTON, J. B., 1994, Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochemical Pharmacology, 47, 1469-1479.
9. LAVE, TH., COASSOLO, P., UBEAUD, G., BRANDT, R., SCHMITT, C., DUPIN, S., JAECK, D., and CHOC, R. C., 1996, Interspecies scaling of bosentan, a new endothelin receptor antagonist and integration of in vitro data into allometric scaling. Pharmaceutical Research, 13, 97-101.
10. LAVE, TH., SCHMITT-HOFFMANN, A. H., COASSOLO, P., UBEAUD, G., VALLÈS, B., BA, B., BRANDT, R., and CHOU, R. C., 1995, A new extrapolation method from animal to man; application to a metabolized compound, mofarotene. Life Sciences, 56, 473-478.
11. MORDENTI, J., 1986, Man versus beast: pharmacokinetic scaling in mammals. Journal of Pharmaceutical Sciences, 75, 1028-1040.
12. MORDENTI, J., CHEN, S. A., MOORE, J. A., FERRAIOLO, B. L., and GREEN, J. D., 1991, Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins. Pharmaceutical Research, 8, 1351-1359.
13. PANG, K. S., KONG, P., TERRELL, J. A., and BILLINGS, R. E., 1985, Metabolism of acetaminophen and phenacetin by isolated rat hepatocytes. A system in which the spatial organization inherent in the liver is disrupted. Drug Metabolism and Disposition, 13, 42-50.
14. RANE, A., WILKINSON, G. R., and SHAND, D. G., 1977, Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance. Journal of Pharmacologv and Experimental Therapeutics, 200, 420-424
15. ROWLAND, M., and TOZER, T., 1989, Clinical Pharmacokinetics : Concepts and Applications (Philadelphia, London: Lea and Febiger).
16. SAWADA, Y., HANANO, M., SUGIYAMA, Y., and IGA, T., 1984, Prediction of the disposition of beta-lactam antibiotics in humans from pharmacokinetic parameters in animals. Journal of Pharmacokinetics and Biopharmaceutics, 12, 241-261.
17. SEDDON, T., MICHELLE, I., and CHENERY, R. J., 1989, Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog. Biochemical Pharmacology, 38, 1657-1665.
18. SEGLEN, P. P., 1976, Preparation of isolated rat liver cells. Methods in Cellular Biology, 13, 29-83.
19. SWABB, E. A., and BONNER, D. P., 1983, Prediction of aztreonam pharmacokinetics in humans based on data from animals. Journal of Pharmacokinetics and Biopharmaceutics, 11, 215-223.
20. UBEAUD, G., SCHMITT, C., JAECK, D., LAVE, TH., and COASSOLO, P., 1995, Bosentan, a new endothelin receptor antagonist: Prediction of the systemic plasma clearance in man from combined in vivo and in vitro data. Xenobiotica, 25, 1381-1390.
21. ZŨRCHER, G., KELLER, H. H., KETTLER, R., BORGULYA, J., BONETTI, E. P., EIGENMANN, R., and DA PRADA, M., 1990, Ro 40-7592, a novel, very potent and orally active inhibitor of catechol-O-methyltransferase: a pharmacological study in rats. Advances in Neurology, 53, 497-503.