Effects of chronic hypoxia on fetal coronary responses

High Altitude Medicine and Biology

Volumn 4, Issue 2, 2003, Pages 215-224

  Thompson, Loren P ^a  

^a NONE

Author keywords

Adaptation; Angiogenesis; Capillary growth; Cardiac metabolism; Flow; Flow reserve

Indexed keywords

ADENOSINE TRIPHOSPHATE;

ADAPTATION; ALTITUDE DISEASE; ANAEROBIC GLYCOLYSIS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR RESPONSE; CHRONIC DISEASE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; FETUS HEART; FETUS HYPOXIA; FETUS MATURITY; GESTATIONAL AGE; HEART FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART PERFUSION; HUMAN; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; REVIEW; SURVIVAL; TISSUE METABOLISM; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

EID: 0041629252     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/152702903322022811     Document Type: Review

References (91)

1. Abdel-Aleem S., St. Louis J.D., Huges G.C., and Lowe J.E. (1999). Metabolic changes in the normal and hypoxic neonatal myocardium. Ann. N.Y. Acad. Sci. 30:254-261.
2. Andres A., Satrustegui J., and Machado A. (1984). Development of enzymes of energy metabolism in rat heart. Biol. Neonate. 45:78-85.
3. Arnet U.A., McMillan A., Dinerman J.L., Ballermann B., and Lowenstein C.J. (1996). Regulation of endothelial nitric oxide synthase during hypoxia. J. Biol. Chem. 271 (25):15069-15073.
4. Ascuitto R.J., and Ross-Ascuitto N.T. (1996). Substrate metabolism in the developing heart. Semin. Perinatol. 20(6):542-563.
5. Barbera A., Giraud G.D., Reller M.D., Maylie J., Morton M.J., and Thornburg K.L. (2000). Right ventricular systolic pressure load alters myocyte maturation in fetal sheep. Am. J. Physiol. Regul. Integrative Comp. Physiol. 279:R1157-R1164.
6. Barker, D.J.P. (1995). Fetal origins of coronary heart disease. BMJ. 311:171-174.
7. Bartelds B., Gratam J.W., Knoester H., Takens J., Smid G.B., Aarnoudse J.G., Heymans. H.A.S., and Kuipers J.R.G. (1998). Perinatal changes in myocardial supply and flux of fatty acids, carbohydrates, and ketone bodies in lambs. Am. J. Physiol. 274(6):H1962-H1969.
8. Battaglia F.C., and Meschia G. (1978). Principle substrates of fetal metabolism. Physiol. Rev. 58(2):499-527.
9. Bocking A.D., Gagnon R., White S.E., Homan J., Milne K.M., and Richardson B.S. (1988). Circulatory responses to prolonged hypoxemia in fetal sheep. Am. J. Obstet. Gynecol. 159:1418-1424.
10. Bogers A.J.J.C., Gittenberger-deGroot A.C., Poelmann R.E., Peault B.M., and Huysmans H.A. (1989). Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth? Anat. Embryol. 180:437-441.
11. Bonne G., Seibel P., Possekel S., Marsac C., and Kadenbach B. (1993). Expression of human cytochrome c oxidase subunits during fetal development. Eur J. Biochem. 217:1099-1107.
12. Brown N.F., Weis B.C., Husti J.E., Foster D.W., and McGarry J.D. (1995). Mitochondrial carnitine palmitoyl-transferase I isoforms switching in the developing rat heart. J. Biol. Chem. 270:8952-8957.
13. Buschmann I., and Schaper W. (1999). Arteriogenesis versus angiogenesis: two mechanisms of vessel growth. News Physiol. Sci. 14:121-125.
14. 2-adrenergic receptors in the coronary microcirculation. Circulation. 84:2108-2122.
15. Cleaver O., and Krieg P.A. (1999). Molecular mechanisms of vascular development. In: Heart Development. R.P. Harvey and N. Rosenthal, eds. Academic Press, San Diego, CA: pp. 221-252.
16. Dalshaug G.B., Scholz T.D., Smith O.M., Bedell K.A., Caldarone C.A., and Segar J.L. (2002). Effects of gestational age on myocardial blood flow and coronary flow reserve in pressure-loaded ovine fetal hearts. Am. J. Physiol. Heart Circ. Physiol. 282:H1359-H1369.
17. Davis L.E., and Hohimer A.R. (1991). Hemodynamics and organ blood flow in fetal sheep subjected to chronic anemia. Am. J. Physiol. 261:R1542-1548.
18. Davis L.E., Hohimer A.R., and Morton M.J. (1999). Myocardial blood flow and coronary reserve in chronically anemic fetal lambs. Am. J. Physiol. 277(1 Pt 2):R306-313.
19. Dunker D., Zhang J., Pavek T., Crampton M., and Bache R. (1995). Effect of exercise on coronary pressure-flow relationship in hypertrophied left ventricle. Am. J. Physiol. Heart Circ. Physiol. 269:H271-H281.
20. Fisher D.J. (1984). Oxygenation and metabolism in the developing heart. Semin. Perinatal. 8:217-225.
21. Fisher D.J., Heymann M.A., and Rudolph A.M. (1980). Myocardial oxygen and carbohydrate consumption in fetal lambs in utero and in adult sheep. Am. J. Physiol. 238 (Heart Circ. Physiol. 9):H399-H405.
22. Fisher D.J., Heymann M.A., and Rudolph A.M. (1982a). Fetal myocardial oxygen and carbohydrate consumption during acutely induced hypoxemia. Am. J. Physiol. 242 (Heart Circ. Physiol. 11):H657-661.
23. Fisher D.J., Heymann M.A., and Rudolph A.M. (1982b). Regional myocardial blood flow and oxygen delivery in fetal, newborn, and adult sheep. Am. J. Physiol. 243 (Heart Circ. Physiol. 12):H729-H731.
24. Flanagan M.F., Aoyagi T., Currier J., Colan S., and Fujii A. (1994). Effect of young age on coronary adaptations to left ventricular pressure overload hypertrophy in sheep. J. Am. Coll. Cardiol. 24:1786-1796.
25. Garcia F.C., Stiffel V.M., and Gilbert R.D. (2000). Effects of long-term high-altitude hypoxia on isolated fetal ovine coronary arteries. J. Soc. Gynecol. Invest. 7:211-217.
26. Georgieff M.K., Schmidt R.L., Mills M.M., Radmer W.J., and Widness J.A. (1992). Fetal iron and cytochrome c status after intrauterine hypoxemia and erythropoietin administration. Am. J. Physiol. 262:R485-R491.
27. Giussani D.A., Riquelme R.A., Moraga F.A., McGarrigle H.H., Gaete C.R., Sanhueza E.M., Hanson M.A., and Llanos A.J. (1996). Chemoreflex and endocrine components of cardiovascular responses to acute hypoxemia in the llama fetus. Am. J. Physiol. 271(1 Pt 2):R73-R83.
28. Giussani D.A., Riquelme R.A., Sanhueza E.M., Hanson M.A., Blanco C.E., and Llanos A.J. (1999). Adrenergic and vasopressinergic contributions to the cardiovascular response to acute hypoxaemia in the llama fetus. J. Physiol. 515 (Pt 1):233-241.
29. Grandtner M., Turek Z., and Kreuzer F. (1974). Cardiac hypertrophy in first generation of rats native to simulated high altitude. Pflugers Arch. 350:241-248.
30. Hanson M. (1998). Role of chemoreceptors in effects of chronic hypoxia. Comp. Biochem. Physiol. A. Mol. Integrative Physiol. 119(3):695-703.
31. Hoerter J. (1976). Changes in the sensitivity to hypoxia and glucose deprivation in the isolated perfused rabbit heart during perinatal development. Pfluegers Arch. 363:1-6.
32. Hoerter J.A., and Opie L.H. (1978). Perinatal changes in glycolytic flux in response to hypoxia in the incubated or perfused rat heart. Biol. Neonate. 33:144-161.
33. Hoerter J.A., Ventura-Clapier R., and Kuznetsov A. (1994). V-1 Compartmentation of creatine kinases during perinatal development of mammalian heart. Mol. Cell. Biochem. 133/134:277-286.
34. Hoffman, J.I. (1984). Maximal coronary flow and the concept of coronary vascular reserve. Circulation. 70: 153-159.
35. Hudlicka O., and Brown M.D. (1996). Postnatal growth of the heart and its blood vessels. J. Vascular Res. 33:266-287.
36. 2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 12:149-162.
37. Jarmakani J.H., Nagatomo T., Nakazawa M., and Langer G.A. (1978a). Effect of hypoxia on myocardial high-energy phosphates in the neonatal mammalian heart. Am. J. Physiol. 235:H475-H481.
38. Jarmakani J.H., Nakazawa M., Nagatomo T., and Langer G.A. (1978b). Effect of hypoxia on mechanical function in the neonatal mammalian heart. Am. J. Physiol. 235:H469-H474.
39. Jensen A., Garnier Y., and Berger R. (1999). Dynamics of fetal circulatory responses to hypoxia and asphyxia. Eur. J. Obstet. Gynecol. Reprod. Biol. 84:155-172.
40. 2 tension. Am. J. Physiol. 271:C1172-C1180.
41. Kamitomo M., Alonso J.G., Okai T., Longo L.D., and Gilbert R.D. (1993). Effects of long-term, high altitude hypoxemia on ovine fetal cardiac output and blood flow distribution. Am. J. Obstet. Gynecol. 169:701-707.
42. Kamitomo M., Longo L.D., and Gilbert R.D. (1994). Cardiac function in fetal sheep during two weeks of hypoxemia. Am. J. Physiol. 266:(Regul. Integrative Comp. Physiol. 35):R1778-R1785.
43. Kamitomo M., Onishi J., Gutierrez I., Stiffel V.M., and Gilbert T.D. (2002). Effects of long-term hypoxia and development on cardiac contractile proteins in fetal and adult sheep. J. Soc. Gynecol. Invest. 9(6):335-341.
44. Kanatsuka H., Lamping K.G., Eastham C.L., Dellsperger K.C., and Marcus M.L. (1989). Comparison of the effects of increased myocardial oxygen consumption and adenosine on the coronary microvascular resistance. Circ. Res. 65:1296-1305.
45. Kayar S.R., and Banchero N. (1985). Myocardial capillarity in acclimation to hypoxia. Pflugers Arch. 404:319-325.
46. Kinnula V.L., and Hassinen I. (1977). Effect of hypoxia on mitochondrial mass and cytochrome concentrations in rat heart and liver during postnatal development. Acta Physiol. Scand. 99:462-466.
47. Kourembanas S., Morita T., Liu Y., and Christou H. (1997). Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. Kidney Int. 51(2):438-443.
48. Kuo L., Davis M.J., and Chilian W.M. (1995). Longitudinal gradients for endothelium-dependent and -independent vascular responses in the coronary circulation. Circulation. 92:518-525.
49. Ladoux A., and Frelin C. (1993). Hypoxia is a strong inducer of vascular endothelial growth factor messenger RNA expression in the heart. Biochem. Biophys. Res. Commun. 195:1005-1010.
50. Lee Y.M., Jeong C.H., Koo SY, Son M.J., Song H.S., Bae S.K., Raleigh J.A., Chung H.Y., Yoo M.A., and Kim K.W. (2001). Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development. Dev. Dyn. 220(2): 175-186.
51. Lewis A.M., Mathieu-Costello C., McMillan P.J., and Gilbert R.D. (1999). Effects of long-term, high-altitude hypoxia on the capillarity of the ovine fetal heart. Am. J. Physiol. 277:(2 Pt2):H756-62.
52. Lopaschuk G.D., Spafford M.A., and Marsh D.R. (1991). Glycolysis is predominant source of myocardial ATP production immediately after birth. Am. J. Physiol. 261(Heart Circ. Physiol. 30):H1698-H1705.
53. Manohar M., Parks C.R., Busch M.A., and Bisgard G.E. (1985). Transmural coronary vasodilator reserve and flow distribution in unanesthetized calves sojourning at 3500m. J. Surg. Res. 39:499-509.
54. Manohar M., Parks C.R., Busch M.A., Tranquelli W.J., and Bisgard G.E. (1982). Regional myocardial blood flow and coronary vascular reserve in unanesthetized young calves exposed to a simulated high altitude or 3500m for 8 to 10 weeks. Circ. Res. 50:714-726.
55. Martin C., Yu A.Y., Jiang B.H., Davis L., Kimberly D., Hohimer A.R., and Semenza G.L. (1998). Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. Am. J. Obstet. Gynecol. 178(3):527-534.
56. Muller D.M., Davis M.J., and Chilian W.M. (1996). Integrated regulation of pressure and flow in the coronary microcirculation. Cardiovasc. Res. 32(4):668-678.
57. Ohtsuka T., and Gilbert R.D. (1995). Cardiac enzyme activities in fetal and adult pregnant and nonpregnant sheep exposed to high-altitude hypoxemia. J. Appl. Physiol. 79(4):1286-1289.
58. Ostadal B., Ostadalova I., Dhalla N.S. (1999). Development of cardiac sensitivity to oxygen deficiency: comparative and ontogenetic aspects. Physiol. Rev. 79(3):635-659.
59. Page A.W.A., Kleinman C.S., Lister G., and Talner N.S. (1998). Cardiovascular function during normal fetal and neonatal development and with hypoxic stress. In: Fetal and Neonatal Physiology, 2nd ed. R. Polin and W. Fox, eds. Saunders, Philadelphia; pp. 837-876.
60. Peeters L.L.H., Sheldon R.E., Jones M.D., Makowski E.L., and Meschia G. (1979). Blood flow to fetal organs as a function of arterial oxygen content. Am. J. Obstet. Gynecol. 135:637-646.
61. Pietschmann M., and Bartels H. (1985). Cellular hyperplasia and hypertrophy, capillary proliferation and myoglobin concentration in the heart of newborn and adult rats at high altitude. Resp. Physiol. 59:347-360.
62. Pinson, C.W., Morton M.J., and Thornburg, K.L. (1987). An anatomic basis for fetal right ventricular dominance and arterial pressure sensitivity. J. Dev. Physiol. 9:253-269.
63. Poelmann R.E., Gittenberger-deGroot A.C., Metink M.M.T., Bokenkamp R., and Hogers B. (1993). Development of the cardiac vascular endothelium, studied with anti-endothelial antibodies in chicken-quail chimeras. Circ. Res. 73:559-568.
64. Pohl U. (1990). Endothelial cells as part of a vascular oxygen-sensing system: hypoxia-incluced release of autacoids. Experientia 46:1175-1179.
65. Reller M.D., Burson M.A., Lohr, J.L., Morton M.J., and Thornburg, K.L. (1995). Nitric oxide is an important determinant of coronary flow at rest and during hypoxemic stress in fetal lambs. Am. J. Physiol. 269(Heart Circ. Physiol. 38):H2074-H2081.
66. Reller, M.D., Morton M.J., Giraud G.D., Wu D.E., and Thornburg, K.L. (1992a). Severe right ventricular pressure loading in fetal sheep augments global myocardial blood flow to submaximal levels. Circulation. 86:581-588.
67. Reller, M.D., Morton M.J., Giraud G.D., Wu D.E., and Thornburg, K.L. (1992b). Maximal myocardial blood flow is enhanced by chronic hypoxemia in late gestation fetal sheep. Am. J. Physiol. 263(Heart Circ. Physiol. 32):H1327-H1329.
68. Richardson B.J., and Bocking A.D. (1998). Metabolic and circulatory adaptations to chronic hypoxia in the fetus. Comp. Biochem. Physiol. 119A:3:717-723.
69. Rudolph A.M. (1981). Fetal cardiovascular responses to stress. Semin. Perinatal. 5(2):109-121.
70. Rudolph A.M. (2000). Myocardial growth before and after birth: clinical implications. Acta Paediatr. 89:129-133.
71. Saiki Y., Konig A., Waddell J., and Rebeyka I.M. (1997). Hemodynamic alteration by fetal surgery accelerates myocyte proliferation in fetal guinea pig hearts. Surgery. 122:412-419.
72. Schaper W., and Ito W.D. (1996). Molecular mechanisms of coronary collateral vessel growth. Circ. Res. 79: 911-919.
73. Semenza G.L. (2000). HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88:1474-1480.
74. Semenza G.L., Agani F., Iyer N., Kotch L., Laughner E., Leung S., and Yu A. (1999). Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1. Ann. N.Y. Acad. Sci. 874:262-268.
75. Sheldon R.E., Peeters L.L.H., Jones M.D., Makowski E.L., and Meschia G. (1979). Redistribution of cardiac output and oxygen delivery in the hypoxemic fetal lamb. Am. J. Obstet. Gynecol. 135:1071-1078.
76. Sunderkotter C., Steinbrink K., Groebeler M., Bhardwaj R., and Sorg C. (1994). Macrophages and angiogenesis. J. Leukocyte Biol. 55:410-422.
77. Thompson, L.P., Aguan K., Pinkas G., and Weiner C.P. (2000). Chronic hypoxia increases the NO contribution of acetylcholine vasodilation of the fetal guinea pig heart. Am. J. Physiol. Regul. Integrative. Comp. Physiol. 279:R1813-R1820.
78. Thornburg K.L., and Reller, M.D. (1999). Coronary flow regulation in the fetal sheep. Am. J. Physiol. 277(Regulatory Integrative Comp. Physiol. 46):R1249-R1260.
79. Toma B.S., Wangler R.D., Dewitt D.F., and Sparks H.V. (1985). Effect of development on coronary vasodilator reserve in the isolated guinea pig heart. Circ. Res. 57:538-544.
80. Tomanek R.J. (1990). Response of the coronary vasculature to myocardial hypertrophy. J. Am. Coll. Cardiol. 15:528-533.
81. Tomanek R.J., Ratajska A., Kitten G.T., Yue X., and Sandra A. (1999). Vascular endothelial growth factor expression coincides with coronary vasculogenesis and angiogenesis. Dev. Dyn. 215(1):54-61.
82. Turek Z., Gandtner M., and Kreuzer F. (1972). Cardiac hypertrophy, capillary and muscle fiber density, muscle fiber diameter, capillary radius and diffusion distance in the myocardium of growing rats adapted to a simulated altitude of 3500m. Pflugers Arch. 335:19-28.
83. Turek Z., Turek-Maischeider M., Classens R.A., Rignalda B.E.M., and Kreutzer F. (1975). Coronary blood flow in rats native to simulated high altitude and in rats exposed to it later in life. Pflugers Arch. 335:49-62.
84. Vlahakes G.J., Turley K., Uhlig P.N., Verrier E.D., and Hoffman J.I.E. (1981). Experimental model of congenital hypertrophy created by pulmonary artery banding in utero. Surg. Forum. 32:233-236.
85. Wothe D., Hohimer A., Morton M., Thornburg K., Giraud G., and Davis L. (2002). Increased coronary blood flow signals growth of coronary resistance vessels in near-term ovine fetuses. Am. J. Physiol. Regul. Integrative Comp. Physiol. 282:R295-R302.
86. Wu D.E., and Thornburg K.L. (1993). Perinatal expression of carnitine palmitoyl transferase II in newborn rat (Abstract). Circulation. 88:I-436.
87. Xiao D., Ducsay C.A., and Zhang L. (2000). Chronic hypoxia and developmental regulation of cytochrome c expression in rats. J. Soc. Gynecol. Invest. 7:279-283.
88. Xu X-P., Pollock J.S., Tanner M.A., and Myers P.R. (1995). Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells. Cardiovasc. Res. 30:841-847.
89. Xue C., Rengasamy A., Le Cras T.D., Koberna P.A., Dailey G.C., and Johns R.A. (1994). Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia. Am. J. Physiol. 267(6 Pt 1):L667-L678.
90. Yu A.Y., Shimoda L.A., Iyer N.V., Huso D.L., Sun X., McWillians R., Beaty T., Sham J.S., Wiener C.M., Sylvester J.T., and Semenza G.L. (1999). Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. J. Clin. Invest. 103:691-696.
91. Yue X., and Tomanek R.J. (1999). Stimulation of coronary vasculogenesis/angiogenesis by hypoxia in cultured embryonic hearts. Dev. Dyn. 216:28-36.