Cytotoxic perforin+ and TIA-1+ infiltrates are associated with cell adhesion molecule expression in dilated cardiomyopathy

European Journal of Heart Failure

Volumn 5, Issue 4, 2003, Pages 469-479

  Noutsias, Michel ^a   Pauschinger, Matthias ^a   Schultheiss, Heinz Peter ^a   Kühl, Uwe ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cell adhesion molecules; Cytotoxic T lymphocytes; Dilated cardiomyopathy; Immunohistochemistry; Inflammatory cardiomyopathy; NK cells; Perforin; TIA 1

Indexed keywords

ANTIGEN; BETA1 INTEGRIN; BETA2 INTEGRIN; CD11B ANTIGEN; CD18 ANTIGEN; CD3 ANTIGEN; CD57 ANTIGEN; CD62E ANTIGEN; CDW49D ANTIGEN; CELL ADHESION MOLECULE; CELL PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; PADGEM PROTEIN; PERFORIN; PROTEIN TIA 1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; CELL INTERACTION; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; ENDOCARDIAL BIOPSY; FEMALE; HEART DILATATION; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MYOCARDITIS; NATURAL KILLER CELL; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS GENOME;

AGED; ANTIGENS, CD18; ANTIGENS, CD3; ANTIGENS, CD57; CARDIOMYOPATHY, DILATED; CELL ADHESION MOLECULES; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA4BETA1; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PHENOTYPE; PORE FORMING CYTOTOXIC PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0041466413     PISSN: 13889842     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-9842(03)00037-0     Document Type: Article

References (37)

1. Liu PP, Mason JW. Advances in the understanding of myocarditis. Circulation 2001;104:1076-82.
2. Richardson P, McKenna W, Bristow M, et al. Report of the 1995 world health organisation/international society and federation of cardiology task force on the definition and classification of cardiomyopathies. Circulation 1996;93:841-2.
3. Aretz HT. Myocarditis: the Dallas criteria. Hum Pathol 1987;18:619-24.
4. Strauer BE, Kandolf R, Mall G, et al. Myocarditis-cardiomyopathy. Consensus Report of the German Association for Internal Medicine, presented at the 100th annual meeting, Wiesbaden, 13 April 1994. Acta Cardiol 1996;51:347-371.
5. Kuhl U, Noutsias M, Seeberg B, Schultheiss HP. Immunohistological evidence for a chronic intramyocardial inflammatory process in dilated cardiomyopathy. Heart 1996;75:295-300.
6. Caforio AL, Baboonian C, McKenna WJ. Postviral autoimmune heart disease-fact or fiction? Eur Heart J 1997;18:1051-5.
7. Noutsias M, Seeberg B, Schultheiss HP, Kuhl U. Expression of cell adhesion molecules in dilated cardiomyopathy: evidence for endothelial activation in inflammatory cardiomyopathy. Circulation 1999;99:2124-31.
8. Badorff C, Noutsias M, Kuhl U, Schultheiss HP. Cell-mediated cytotoxicity in hearts with dilated cardiomyopathy: correlation with interstitial fibrosis and foci of activated T lymphocytes. J Am Coll Cardiol 1997;29:429-34.
9. Wojnicz R, Nowalany-Kozielska E, Wojciechowska C, et al. Randomised, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results. Circulation 2001;104:39-45.
10. Mason JW, O'Connell JB, Herskowitz A, et al. A clinical trial of immunosuppressive therapy for myocarditis. The myocarditis treatment trial investigators. N Engl J Med 1995;333:269-75.
11. Parrillo JE. Inflammatory cardiomyopathy (myocarditis): which patients should be treated with anti-inflammatory therapy? Circulation 2001;104:4-6.
12. van den Broek MF, Hengartner H. The role of perforin in infections and tumour surveillance. Exp Physiol 2000;85:681-5.
13. Berke G. The CTL's kiss of death. Cell 1995;81:9-12.
14. Matsumoto G, Nghiem MP, Nozaki N, Schmits R, Penninger JM. Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicity. J Immunol 1998;160:5781-9.
15. Ritz J, Schmidt RE, Michon J, Hercend T, Schlossman SE Characterisation of functional surface structures on human natural killer cells Adv Immunol 1988;42:181-211.
16. World medical association declaration of helsinki. Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc Res 1997;35:2-3.
17. Pauschinger M, Bowles NE, Fuentes-Garcia FJ, et al. Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. Circulation 1999;99:1348-54.
18. Wojnicz R, Nowaany-Kozielska E, Wodniecki J, et al. Immunohistological diagnosis of myocarditis. Potential role of sarcolemmal induction of the MHC and ICAM-1 in the detection of autoimmune mediated myocyte injury. Eur Heart J 1998;19:1564-72.
19. Ino T, Kishiro M, Okubo M, et al. Late persistent expressions of ICAM-1 and VCAM-1 on myocardial tissue in children with lymphocytic myocarditis. Cardiovasc Res 1997;34:32-38.
20. Berke G. Unlocking the secrets of CTL and NK cells. Immunol Today 1995;16:343-6.
21. Devaux B, Scholz D, Hirche A, Klovekorn WP, Schaper J. Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur Heart J 1997;18:470-9.
22. Noutsias M, Pauschinger M, Kuhl U, Schultheiss HP. Myocarditis and dilated cardiomyopathy. New methods in diagnosis and therapy. MMW Fortschr Med 2002;144:36-40.
23. Noutsias M, Pauschinger M, Ostermann K, et al. Digital image analysis system for the quantification of infiltrates and cell adhesion molecules in inflammatory cardiomyopathy. Med Sci Monit 2002;8:59-71.
24. Terasaki F, Okabe M, Hayashi T, et al. Myocardial inflammatory cell infiltrates in cases of dilated cardiomyopathy: light microscopic, immunohistochemical, and virological analyses of myocardium specimens obtained by partial left ventriculectomy. J Card Surg 1999;14:141-6.
25. Liu CC, Walsh CM, Young JD. Perforin: structure and function. Immunol Today 1995;16:194-201.
26. Seko Y, Shinkai Y, Kawasaki A, et al. Evidence of perforin-mediated cardiac myocyte injury in acute murine myocarditis caused by Coxsackievirus B3. J Pathol 1993;170:53-8.
27. Griffiths GM, Namikawa R, Mueller C, et al. Granzyme A and perforin as markers for rejection in cardiac transplantation. Eur J Immunol 1991;21:687-93.
28. Yannelli JR, Sullivan JA, Mandell GL, Engelhard VH. Reorientation and fusion of cytotoxic T-lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography. J Immunol 1986;136:377-82.
29. Gebhard JR, Perry CM, Harkins S, et al. Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance. Am J Pathol 1998;153:417-28.
30. Springer TA. Adhesion receptors of the immune system. Nature 1990;346:425-34.
31. Staudt A, Schaper F, Stangl V, et al. Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution. Circulation 2001;103:2681-6.
32. Baboonian C, Treasure T. Meta-analysis of the association of enteroviruses with human heart disease. Heart 1997;78:539-43.
33. Pauschinger M, Doemer A, Kuehl U, et al. Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis. Circulation 1999;99:889-95.
34. Andreoletti L, Bourlet T, Moukassa D, et al. Enteroviruses can persist with or without active viral replication in cardiac tissue of patients with end-stage ischemic or dilated cardiomyopathy. J Infect Dis 2000;182:1222-7.
35. Hauck AJ, Kearney DL, Edwards WD. Evaluation of postmorrem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error. Mayo Clin Proc 1989;64:1235-45.
36. Dettmeyer R, Reith K, Madea B. Alcoholic cardiomyopathy vs. chronic myocarditis-immunohistological investigations with LCA, CD3, CD68 and tenascin. Forensic Sci Int 2002;126:57-62.
37. Mahon NG, Madden BP, Caforio AL, et al. Immunohistologic evidence of myocardial disease in apparently healthy relatives of patients with dilated cardiomyopathy. J Am Coll Cardiol 2002;39:455-62.