Cell-mediated cytotoxicity in hearts with dilated cardiomyopathy: Correlation with interstitial fibrosis and foci of activated T lymphocytes

Journal of the American College of Cardiology

Volumn 29, Issue 2, 1997, Pages 429-434

  Badorff, Cornel ^a   Noutsias, Michel ^b   Kühl, Uwe ^b   Schultheiss, Heinz Peter ^b  

^a NONE   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE ANTIGEN;

ADULT; AGED; ARTICLE; CARDIOMYOPATHY; CYTOTOXICITY; FEMALE; FIBROSIS; HUMAN; IDIOPATHIC DISEASE; IMMUNOHISTOLOGY; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BIOLOGICAL MARKERS; CARDIOMYOPATHY, DILATED; CYTOTOXICITY, IMMUNOLOGIC; ENDOCARDIUM; FEMALE; FIBROSIS; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MYOCARDIUM; PORE FORMING CYTOTOXIC PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031019733     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(96)00475-5     Document Type: Article

References (34)

1. Sole MJ, Liu P. Viral myocarditis: a paradigm for understanding the pathogenesis of dilated cardiomyopathy. J Am Coll Cardiol 1993;22 Suppl A:99A-105A.
2. Martino TA, Liu P, Sole MJ. Viral infection and the pathogenesis of dilated cardiomyopathy. Circ Res 1994;74:182-8.
3. Schultheiss HP. Disturbance of myocardial energy metabolism in dilated cardiomyopathy due to autoimmunological mechanisms. Circulation 1993;87 Suppl IV:IV-43-8.
4. Limas CL, Goldenberg IF, Limas C. Soluble interleukin-2 receptor levels in patients with dilated cardiomyopathy. Circulation 1995;91:631-4.
5. Mason JW, O'Connell JB. Clinical merit of endomyocardial biopsy. Circulation 1989;79:971-9.
6. Manolio TA, Baughman KL, Rodeheffer R, et al. Prevalence and etiology of idiopathic dilated cardiomyopathy (summary of a National Heart, Lung and Blood Institute Workshop). Am J Cardiol 1992;69:1458-66.
7. Roberts WC, Siegel RJ, McManus BM. Idiopathic dilated cardiomyopathy: analysis of 152 necropsy patients. Am J Cardiol 1987;60:1340-55.
8. Aretz HT. Myocarditis: the DALLAS criteria. Hum Pathol 1987;18:619-24.
9. Kasper EK, Agema WRP, Hutchins GM, Deckers JW, Hare JM, Baugham KL. The causes of dilated cardiomyopathy: a clinicopathologic review of 673 consecutive patients. J Am Coll Cardiol 1994;23:586-90.
10. Kühl U, Noutsias M, Seeberg B, Schultheiss H-P. Immunohistological evidence for a chronic intramyocardial inflammatory process in dilated cardiomyopathy. Heart 1996;75:295-300.
11. Ansari AA, Wang YC, Danner DJ, et al. Abnormal expression of histocompatibility and mitochondrial antigens by cardiac tissue from patients with myocarditis and dilated cardiomyopathy. Am J Pathol 1991;139:337-54.
12. Kühl U, Noutsias M, Seeberg B, Schanwell M, Welp LB, Schultheiss HP. Chronic inflammation in the myocardium of patients with clinically suspected dilated cardiomyopathy. J Cardiac Failure 1994;1:13-25.
13. Barry WH. Mechanisms of immune-mediated myocyte injury. Circulation 1994;89:2421-32.
14. Hudig D, Ewoldt GR, Woodard SL. Proteases and lymphocyte killing mechanisms. Curr Opin Immunol 1993;5:90-6.
15. Liu CC, Walsh CM, Young JDE. Perforin: structure and function. Immunol Today 1995;16:194-201.
16. Acha-Orchea H, Scarpellino L, Hertig S, Dupuis M, Tschopp J. Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides. EMBO J 1990;9:3815-9.
17. Kägi D, Ledermann B, Bürki K et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 1994;369:31-7.
18. Nakata M, Kawasaki A, Azuma M, et al. Expression of perforin and cytolytic potential of human peripheral blood lymphocyte subpopulations. Int Immunol 1992;4:1049-54.
19. Tian Q, Taupin J, Elledge S, Robertson M, Anderson P. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during FAS-mediated apoptosis. J Exp Med 1995;182:865-74.
20. Tian Q, Streuli M, Saito H, Schlossman SF, Anderson P. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. Cell 1991;67:629-39.
21. Report of the WHO/ISFC Task Force on the definition and classification of cardiomyopathies. Br Heart J 1980;44:672-3.
22. Hameed A, Olsen KJ, Cheng W, Fox WM III, Hruban RH, Podack ER. Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody. Am J Pathol 1992;140:1025-30.
23. Bayer EA, Wichek M. The use of avidin-biotin complex as a tool in molecular biology. Methods Biochem Anal 1980;26:1-45.
24. Felzen B, Berke G, Rosen D, et al. Effects of purified perforin and granzyme A from cytotoxic T lymphocytes on guinea pig ventricular myocytes. Cardiovasc Res 1994;28:643-9.
25. Seko Y, Shinkai Y, Kawasaki A, et al. Expression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by Coxsackie virus B3. Circulation 1991;84:788-95.
26. Seko Y, Shinkai Y, Kawasaki A, et al. Evidence of perforin-mediated cardiac myocyte injury in acute murine myocarditis caused by Coxsackie virus B3. J Pathol 1993;170:53-8.
27. Young LH, Joag SW, Zheng LM, Lee CP, Lee YS, Young JDE. Perforin-mediated myocardial damage in acute myocarditis. Lancet 1990;336:1019-21.
28. β genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. J Clin Invest 1995;96:1035-41.
29. Ojcius DM, Zheng LM, Sphicas EC, Zychlinsky A, Young JDE. Subcellular localization of perforin and serine esterase in lymphokine-activated killer cells and cytotoxic T cells by immunogold labelling. J Immunol 1991;146: 4427-32.
30. Holzinger C, Schöllhammer A, Imhof M, et al. Phenotypic pattern of mononuclear cells in dilated cardiomyopathy. Circulation 1995;92:2876-85.
31. Clark JG, Dedon TF, Wayner EA, Carter WG. Effects of interferon-γ on expression of cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts. J Clin Invest 1989;83:1505-11.
32. Keren A, Gottlieb S, Tzivoni D, et al. Mildly dilated cardiomyopathy - use of prospective diagnostic criteria and description of the clinical course without heart transplantation. Circulation 1990;81:506-17.
33. McMichel AJ, Ting A, Zweevink HF, Askonas BA. HLA restriction of cell mediated lysis of influenza virus infected human cells. Nature 1977;270: 524-6.
34. Hauck AJ, Kearney DL, Edwards WD. Evaluation of post-mortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implication for role of sampling error. Mayo Clin Proc 1989;64:1235-45.