A threonine residue (Thr71) at the intracellular end of the M1 helix plays a critical role in the gating of Kir6.2 channels by intracellular ATP and protons

Journal of Membrane Biology

Volumn 192, Issue 2, 2003, Pages 111-122

  Cui, N ^a   Wu, J ^a   Xu, H ^a   Wang, R ^a   Rojas, A ^a   Piao, H ^a   Mao, J ^a   Abdulkadir, L ^a   Li, L ^a   Jiang, C ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

ATP; Coronary heart disease; Diabetes; Hypercapnia; KATP; Kir6.2; pH

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTAMIC ACID; POTASSIUM CHANNEL; PROTEIN SUBUNIT; PROTON; THREONINE;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; GENE MUTATION; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PH;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARBON DIOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICE; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN CONFORMATION; PROTONS; RECOMBINANT PROTEINS; THREONINE; XENOPUS LAEVIS;

ANIMALIA;

EID: 0041426763     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-002-1069-6     Document Type: Article

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