Center stage for the serotonin transporter: A gain-of-function polymorphism in persons with obsessive-compulsive disorder

Molecular Pharmacology

Volumn 64, Issue 2, 2003, Pages 196-198

  Torres, Gonzalo E ^a   Caron, Marc G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE; CELL MEMBRANE PROTEIN; COCAINE; DOPAMINE TRANSPORTER; NORADRENALIN TRANSPORTER; PSYCHOSTIMULANT AGENT; SEROTONIN TRANSPORTER;

ALLELE; ATTENTION DEFICIT DISORDER; DEPRESSION; DRUG TARGETING; EATING DISORDER; GENE MUTATION; GENE TARGETING; GENETIC POLYMORPHISM; HUMAN; MONOAMINERGIC SYSTEM; NEUROTRANSMITTER RELEASE; OBSESSIVE COMPULSIVE DISORDER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; TANDEM REPEAT;

CARRIER PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; OBSESSIVE-COMPULSIVE DISORDER; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0041341961     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.2.196     Document Type: Review

References (17)

1. Amara SG and Sonders MS (1998) Neurotransmitter transporters as molecular targets for addictive drugs. Drug Alcohol Depend 51:87-96
2. 3H]serotonin into rat brain synaptosomes. Jpn J Pharmacol 75:123-128.
3. DiMaio S, Grizenko N, and Joober R (2003) Dopamine genes and attention-deficit hyperactivity disorder: a review. J Psychiatry Neurosci 28:27-38.
4. Gainetdinov RR and Caron MG (2003) Monoamine transporters: from genes to behavior. Annu Rev Pharmacol Toxicol 43:261-284.
5. Hahn MK and Blakely RD (2002) Single nucleotide polymorphisms in the human norepinephrine transporter gene assessed by pyrosequencing. 32nd Annual Meeting of the Society for Neuroscience; 2002 Nov 2-7; Orlando, FL. Program no. 646.14.
6. Hastrup H, Karlin A, and Javitch JA (2001) Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment. Proc Natl Acad Sci USA 98:10055-10060.
7. Heils A, Mossner R and Lesch KP (1997) The human serotonin transporter gene polymorphism - basic research and clinical implications. J Neural Transm 104:1005-1014.
8. Kilic F and Rudnick G (2000) Oligomerization of serotonin transporter and its functional consequences. Proc Natl Acad Sci USA 97:3106-3111.
9. Kilic F, Murphy DL, and Rudnick G (2003) A human serotonin transporter mutation causes constitutive activation of transporter activity. Mol Pharmacol 64:440-446.
10. Lin Z and Uhl GR (2003) Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities. Pharmacogenomics, in press.
11. Mazei MS and Blakely RD (2002) Evaluation of nonsynonymous single nucleotide polymorphisms in the human dopamine transporter. 32nd Annual Meeting of the Society for Neuroscience; 2002 Nov 2-7; Orlando, FL. Program no. 442.4.
12. Miller KJ and Hoffman BJ (1994) Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP. J Biol Chem 269:27351-27356.
13. Ozaki N, Goldman D, Kaye WH, Plotnikov K, Greenberg BD, Rudnick G, and Murphy DL (2003) A missense mutation in the serotonin transporter is associated with a complex neuropsychiatric phenotype Mol Psychiatry, in press.
14. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, and Robertson D (1999) Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 342:541-549.
15. Sorkina T, Doolen S, Galperin E, Zahnisev NR, and Sorkin A (2003) Oligomerization of dopamine transporters visualized in living cells by FRET microscopy. J Biol Chem, in press.
16. Torres GE, Carneiro A, Seamans K, Fiorentini C, Sweeney A, Yao WD and Caron MG (2003a) Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. J Biol Chem 278:2731-2739.
17. Torres GE, Gainetdinov RR, and Caron MG (2003b) Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci 4:13-25.