Differential modulation of Ku70/80 DNA-binding activity in a patient with multiple basal cell carcinomas

Journal of Investigative Dermatology

Volumn 121, Issue 3, 2003, Pages 628-633

  Mazzarelli, Paola ^a,b   Rabitti, Carla ^a   Parrella, Paola ^c   Seripa, Davide ^c   Persichetti, Paolo ^a   Marangi, Giovanni Francesco ^a   Perrone, Giuseppe ^a   Poeta, Maria Luana ^a   Delfino, Mario ^b   Fazio, Vito Michele ^a,c  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

Caretaker activity; DNA doublestrand break repair; Ku70 80 heterodimer; Tumor progression

Indexed keywords

DOUBLE STRANDED DNA; KI 67 ANTIGEN; KU ANTIGEN; KU80 PROTEIN; MOLECULAR MARKER; PROTEIN; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BASAL CELL CARCINOMA; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA STRAND BREAKAGE; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; IONIZING RADIATION; MULTIPLE BASAL CELL CARCINOMA; MULTIPLE CANCER; PRIORITY JOURNAL; SKIN BIOPSY; TUMOR BIOPSY; TUMOR GROWTH;

EID: 0041333143     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12416.x     Document Type: Article

References (42)

1. Abdelsayed RA, Guijarro-Rojas M, Ibrahim NA, Sangueza OP: Immunohistochemical evaluation of basal cell carcinoma and trichepithelioma using Bcl-2, Ki67, PCNA and p53. J Cutan Pathol 27:169-175, 2000
2. Barrett TL, Smith KJ, Hodge JJ, Butler R, Hall FW, Skelton HG: Immunohistochemical nuclear staining for p53, PCNA, and Ki-67 in different histologic variants of basal cell carcinoma. J Am Acad Dermatol 37 (3: Pt 1):430-437, 1997
3. Brown KD, Lataxes TA, Shangary S, Mannino JL, Giardina JF, Chen J, Baskaran R: Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxiatelangiectasia-mutated protein-dependent mechanism. J Biol Chem 275:6651-6656, 2000
4. Chu G: Double strand break repair. J Biol Chem 272:Z4097-Z4100, 1997
5. De Vita VT Jr, Hellman S, Rosenberg SA: Cancer: Principles and Practice of Oncology, 5th edn. Philadelphia: Lippincott-Raven Publishers, 1992
6. Difilippantonio MJ, Zhu J, Chen HT, et al: A DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404:510-514, 2000
7. Dignam JD, Lebovitz RM, Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489, 1983
8. Farndon PA, Del Mastro RG, Evans DG, Kilpatrick MW: Location of gene for Gorlin syndrome. Lancet 339:581-582, 1992
9. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61:759-767, 1990
10. Featherstone C, Jackson SP: Ku, a DNA repair protein with multiple cellular functions? Mutat Res 434:3-15, 1999
11. Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW: The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 97:6630-6633, 2000
12. Frasca D, Barattini P, Goso C, et al: Cell proliferation and Ku protein expression in ageing humans. Mech Ageing Dev 100:197-208, 1998
13. Gailani MR, Bale AE: Developmental genes and cancer: Role of patched in basal cell carcinoma of the skin. J Natl Cancer Inst 89:1103-1109, 1997
14. Gao Y, Ferguson DO, Xie W, et al: Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404:897-900, 2000
15. Goldstein AM, Stewart C, Bale AE, Bale SJ, Dean M: Localization of the gene for the nevoid basal cell carcinoma syndrome. Am J Hum Genet 54:765-773, 1994
16. Gottlober P, Krahn G, Bezold G, Peter RU: Basal cell carcinomas occurring after accidental exposure to ionizing radiation. Br J Dermatol 141:383-385, 1999
17. Grossman L, Wie Q: DNA repair and epidemiology of basal cell carcinoma. Clin Chem 41:1854-1863, 1995
18. Healy E, Angus B, Lawrence CM, Rees JL: Prognostic value of Ki67 antigen expression in basal cell carcinomas. Br J Dermatol 133:737-741, 1995
19. Jacobs GH, Rippey JJ, Altini M: Prediction of aggressive behavior in basal cell carcinoma. Cancer 49:533-537, 1982
20. Jin S, Weaver D: Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. EMBO J 16:6874-6885, 1997
21. Karagas MR, McDonald JA, Greenberg R, Stukel TA, Weiss JE, Baron JA, Stevens MM: Risk of basal cell and squamous cell skin cancers after ionizing radiation therapy. J Natl Cancer Inst 88:1848-1853, 1996
22. Khanna KK, Jackson SP: DNA double-strand breaks: Signaling, repair and the cancer connection. Nature Gen 27:247-254, 2001
23. Kinzler KW, Vogelstein B: Gatekeepers and caretakers. Nature 386:761-763, 1997
24. Lichter MD, Karagas MR, Mott LA, Spencer SK, Stukel TA, Greenberg ER: Therapeutic ionizing radiation and the incidence of basal cell carcinoma and squamous cell carcinoma. Arch Dermatol 136:1007-1011, 2000
25. Lim DS, Vogel H, Willerford DM, Sands AT, Platt KA, Hasty P: Analysis of Ku80-mutant mice and cells with deficient levels of p53. Mol Cell Biol 20:3772-3780, 2000
26. Milroy CJ, Horlock N, Wilson GD, Sanders R: Aggressive basal cell carcinoma in young patients: Fact or fiction? Br J Plast Surg 53:393-596, 2000
27. Parrella P, Xiao Y, Fliss M, et al: Detection of mitochondrial DNA mutations in primary breast cancer and fine needle aspirates. Cancer Res 61:7623-7626, 2001
28. Prives C, Hall PA: The p53 pathway. J Pathol 187:112-126, 1999
29. Pucci S, Mazzarelli P, Rabitti C, et al: Tumor specific modulation of Ku70/80 DNA binding activity in breast and bladder human tumor biopsies. Oncogene 20:739-747, 2001
30. Ramdial PK, Madaree A, Reddy R, Chetty R: Bcl-2 protein expression in aggressive and non-aggressive basal cell carcinomas. J Cutan Pathol 27:283-291, 2000
31. Rigas B, Borgo S, Elhosseiny A, et al: Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis. Cancer Res 61:8381-8384, 2001
32. Rippey JJ: Why classify basal cell carcinomas? Histopathology 32:393-398, 1998
33. Rippey JJ, Rippey E: Characteristics of incompletely excised basal cell carcinomas of the skin. Med J Aust 166:581-583, 1997
34. Ron E, Preston DL, Kishikawa M, et al: Skin tumor risk among atomic-bomb survivors in Japan. Cancer Causes Control 9:393-401, 1998
35. Roth DB, Gellert M: New guardians of the genome. Nature 404:823-825, 2000
36. Seripa D, Parrella P, Gallucci M, et al: Sensitive detection of transitional cell carcinoma of the bladder by microsatellite analysis of cells exfoliated in urine. Int J Cancer 93:364-369, 2001
37. Smider V, Chu G: The end-joining reaction in V(D)J recombination. Semin Immunol 9:189-197, 1997
38. Staibano S, Lo Muzio L, Pannone G, et al: Interaction between bcl-2 and p53 in neoplastic progression of basal cell carcinoma of the head and neck. Anticancer Res 21 (6A):3757-3764, 2001
39. Umekita Y, Kobayashi K, Saheki T, Yoshida H: Nuclear accumulation of p53 protein correlates with mutations in the p53 gene on archival paraffin-embedded tissues of human breast cancer. Jpn J Cancer Res 85:825-830, 1994
40. UNSCEAR Report: Annex D: Exposures from the Chernobyl Accident. UNSCEAR, 1988; p 1-74
41. Wicking C, Berkman J, Wainwright B, Chenevix-Trench G: Fine genetic mapping of the gene for nevoid basal cell carcinoma syndrome. Genomics 22:505-511, 1994
42. Zhang WW, Yaneva M: On the mechanism of Ku protein binding to DNA. Biochem Biophys Res Commun 186:574-579, 1992