Highly water-soluble derivatives of the anesthetic agent propofol: In vitro and in vivo evaluation of cyclic amino acid esters

European Journal of Pharmaceutical Sciences

Volumn 20, Issue 1, 2003, Pages 17-26

  Altomare, Cosimo ^a   Trapani, Giuseppe ^a   Latrofa, Andrea ^a   Serra, Mariangela ^b   Sanna, Enrico ^b   Biggio, Giovanni ^b   Liso, Gaetano ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Sez Microbiologia   (Italy)

Author keywords

Anesthetic activity; Lipophilicity; Propofol; Stability; Water soluble prodrugs

Indexed keywords

AMINO ACIDS; DERIVATIVES; LIQUID CHROMATOGRAPHY; SOLUBILITY; WATER;

ANESTHETIC AGENTS;

ESTERS;

4 AMINOBUTYRIC ACID A RECEPTOR; AMINO ACID DERIVATIVE; ANESTHETIC AGENT; ESTER DERIVATIVE; ESTERASE; ISONIPECOTATE; LIVER ENZYME; NIPECOTIC ACID DERIVATIVE; PRODRUG; PROLINATE; PROLINE DERIVATIVE; PROPOFOL; TERT BUTYLBICYCLOPHOSPHOROTHIOATE S 35; UNCLASSIFIED DRUG; WATER;

ALLOSTERISM; ANESTHESIA; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG MECHANISM; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MEASUREMENT; MOLECULAR CLONING; NONHUMAN; PH; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR AFFINITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0041331768     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00161-1     Document Type: Article

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