Détermination du sexe des mammifères: La mise à jour d’un trafic?

Medecine/Sciences

Volumn 19, Issue 1, 2003, Pages 25-26

  Gasca, Stéphan ^a   Boizet Bonhoure, Brigitte ^a   Poulat, Francis ^a   Berta, Philippe ^a  

^a INSTITUTE OF HUMAN GENETICS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HIGH MOBILITY GROUP PROTEIN; LEPTOMYCIN B; NUCLEAR PROTEIN; SOX-9 TRANSCRIPTION FACTOR; TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX9; UNSATURATED FATTY ACID;

ANIMAL; BIOLOGICAL MODEL; CELL NUCLEUS; CONFERENCE PAPER; CYTOPLASM; DRUG EFFECT; FEMALE; GENDER AND SEX; GENE EXPRESSION REGULATION; GENETICS; GERM CELL; GONAD; HUMAN; MALE; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PRENATAL DEVELOPMENT; SEX CHROMOSOME; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CYTOPLASM; DNA-BINDING PROTEINS; FATTY ACIDS, UNSATURATED; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GERM CELLS; GONADS; HIGH MOBILITY GROUP PROTEINS; HUMANS; MALE; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; ORGAN CULTURE TECHNIQUES; SEX CHROMOSOMES; SEX DETERMINATION (GENETICS); SEX-DETERMINING REGION Y PROTEIN; TRANSCRIPTION FACTORS;

EID: 0041306053     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/200319125     Document Type: Article

References (10)

1. The genetics and biology of sex determination. In: Chadwick D, Goode J, eds. Novartis found symposium 244. London: John Wiley and Sons Ltd, 2002: 266 p.
2. Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990; 346: 240-4.
3. Schmahl J, Eicher EM, Washburn LL, Capel B. Sry induces cell proliferation in the mouse gonad. Development 2000; 127:65-73.
4. Bowles J, Schepers G, Koopman P. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 2000; 227:239-55.
5. De Santa Barbara P, Bonneaud N, Boizet B, et al. Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene. Mol Cell Biol 1998; 18: 6653-65.
6. Arango NA, Lovell-Badge R, Behringer RR. Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Cell 1999; 99: 409-19.
7. Morais da Silva S, Hacker A, Harley V, Goodfellow P, Swain A, Lovell-Badge R. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet 1996; 14: 62-8.
8. Sudbeck P, Scherer G. Two independent nuclear localization signals are present in the DNA- binding high-mobility group domains of SRY and SOX9. J Biol Chem 1997; 272: 27848-52.
9. De Santa Barbara P, Moniot B, Poulat F, Berta P. Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development. Dev Dyn 2000; 217: 293-8.
10. Gasca S, Cañizares J, de Santa Barbara P, et al. A nuclear export signal within the HMG domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination. Proc Natl Acad Sci USA 2002; 99: 11199-204.