메뉴 건너뛰기




Volumn 41, Issue 2, 2000, Pages 113-127

Dose and dose-rate effects of X rays and fission neutrons on lymphocyte apoptosis in p53(+/+) and p53(-/-) mice

Author keywords

Dose rate independent apoptosis; Hyperplasia; p53; RBE of fission neutrons; Thymus atrophy

Indexed keywords

FISSION REACTIONS; LYMPHOCYTES; MAMMALS; NEUTRON IRRADIATION; NEUTRONS; THYMUS;

EID: 0041082929     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.41.113     Document Type: Article
Times cited : (35)

References (28)
  • 1
    • 0040340740 scopus 로고
    • Relative radiosensitivities of the thymus, spleen and lymphohemopoietic systems
    • Maruyama, Y. and Feola, J. M. (1987) Relative radiosensitivities of the thymus, spleen and lymphohemopoietic systems. Adv. Radiat. Biol. 12: 1-82.
    • (1987) Adv. Radiat. Biol. , vol.12 , pp. 1-82
    • Maruyama, Y.1    Feola, J.M.2
  • 2
    • 0040340756 scopus 로고
    • Cytologic changes in thymic glands exposed in vivo to X rays
    • Schrek, R. (1948) Cytologic changes in thymic glands exposed in vivo to X rays. Am. J. Pathol. 24: 1055-1067.
    • (1948) Am. J. Pathol. , vol.24 , pp. 1055-1067
    • Schrek, R.1
  • 3
    • 84965183644 scopus 로고
    • The reaction of the mouse thymus to X-rays measured by changes in organ weight
    • Kallman, R. F. and Kohn, H. I. (1955) The reaction of the mouse thymus to X-rays measured by changes in organ weight. Radiat. Res. 2: 280-293.
    • (1955) Radiat. Res. , vol.2 , pp. 280-293
    • Kallman, R.F.1    Kohn, H.I.2
  • 4
    • 0005499465 scopus 로고
    • The relative biological effectiveness of various ionizing radiations in mammalian systems
    • Storer, J. B., Harris, P. S., Furchner, J. E. and Langham, W. H. (1957) The relative biological effectiveness of various ionizing radiations in mammalian systems. Radiat. Res. 6: 188-288.
    • (1957) Radiat. Res. , vol.6 , pp. 188-288
    • Storer, J.B.1    Harris, P.S.2    Furchner, J.E.3    Langham, W.H.4
  • 5
    • 0023847959 scopus 로고
    • Radiation-induced interphase death of rat lymphocytes is internally programmed (apoptosis)
    • Yamada, T. and Ohyama, H. (1988) Radiation-induced interphase death of rat lymphocytes is internally programmed (apoptosis). Int. J. Radiat. Biol. 53: 65-75.
    • (1988) Int. J. Radiat. Biol. , vol.53 , pp. 65-75
    • Yamada, T.1    Ohyama, H.2
  • 6
    • 0026824656 scopus 로고
    • Programmed cell death in whole body and organ systems by low dose radiation
    • Nomura, T., Kinuta, M., Hongyo, T., Nakajima, H. and Hatanaka, T. (1992) Programmed cell death in whole body and organ systems by low dose radiation. J. Radiat. Res. Suppl. 33: 109-123.
    • (1992) J. Radiat. Res. Suppl. , vol.33 , pp. 109-123
    • Nomura, T.1    Kinuta, M.2    Hongyo, T.3    Nakajima, H.4    Hatanaka, T.5
  • 7
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • Surh, C. D. and Sprent, J. (1994) T-Cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372: 100-103.
    • (1994) Nature , vol.372 , pp. 100-103
    • Surh, C.D.1    Sprent, J.2
  • 8
    • 0027319521 scopus 로고
    • p53 is required for radiation induced apoptosis in mouse thymocytes
    • Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborn, B. A. and Jacks, T. (1993) p53 is required for radiation induced apoptosis in mouse thymocytes. Nature 362: 847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborn, B.A.4    Jacks, T.5
  • 10
    • 0031715345 scopus 로고    scopus 로고
    • The high susceptibility of heterozygous p53(+/-) mice to malformation after fetal irradiation is related to sub-competent apoptosis
    • Nomoto, H., Ootsuyama, A., Shioyama, Y., Katsuki, M., Kondo, S. and Norimura, T. (1998) The high susceptibility of heterozygous p53(+/-) mice to malformation after fetal irradiation is related to sub-competent apoptosis. Int. J. Radiat. Biol. 74: 419-429.
    • (1998) Int. J. Radiat. Biol. , vol.74 , pp. 419-429
    • Nomoto, H.1    Ootsuyama, A.2    Shioyama, Y.3    Katsuki, M.4    Kondo, S.5    Norimura, T.6
  • 11
    • 0033088948 scopus 로고    scopus 로고
    • Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation
    • Ghosh, J. C., Suzuki, K., Kodama, S. and Watanabe, M. (1998) Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation. J. Radiat. Res. 40: 23-37.
    • (1998) J. Radiat. Res. , vol.40 , pp. 23-37
    • Ghosh, J.C.1    Suzuki, K.2    Kodama, S.3    Watanabe, M.4
  • 12
    • 0029874308 scopus 로고    scopus 로고
    • p53-dependent apoptosis suppresses radiation-induced teratogenesis
    • Norimura, T., Nomoto, S., Katsuki, M., Gondo, Y. and Kondo, S. (1996) p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nature Med. 2: 577-580.
    • (1996) Nature Med. , vol.2 , pp. 577-580
    • Norimura, T.1    Nomoto, S.2    Katsuki, M.3    Gondo, Y.4    Kondo, S.5
  • 13
    • 0025086048 scopus 로고
    • Induced rates of mitotic crossing over and possible mitotic gene conversion per wing anlage cell in Drosophila melanogaster by X rays and fission neutrons
    • Ayaki, T., Fujikawa, K., Ryo, H., Itoh, T. and Kondo, S. (1990) Induced rates of mitotic crossing over and possible mitotic gene conversion per wing anlage cell in Drosophila melanogaster by X rays and fission neutrons. Genetics 126: 157-166.
    • (1990) Genetics , vol.126 , pp. 157-166
    • Ayaki, T.1    Fujikawa, K.2    Ryo, H.3    Itoh, T.4    Kondo, S.5
  • 14
    • 0020364208 scopus 로고
    • Cell death (apoptosis) in the mouse small intestine after low doses; effects of dose-rate, 14.7 MeV neutrons, and 600 MeV (maximum energy) neutrons
    • Hendry, J. H., Potten, C. S., Chadwick, C. and Bianchi, M. (1982) Cell death (apoptosis) in the mouse small intestine after low doses; effects of dose-rate, 14.7 MeV neutrons, and 600 MeV (maximum energy) neutrons. Int. J. Radiat. Biol. 42: 611-620.
    • (1982) Int. J. Radiat. Biol. , vol.42 , pp. 611-620
    • Hendry, J.H.1    Potten, C.S.2    Chadwick, C.3    Bianchi, M.4
  • 15
    • 0031941549 scopus 로고    scopus 로고
    • RBE for the induction of apoptosis in human peripheral lymphocytes exposed in vitro to high-LET radiation generated by accelerated nitrogen ions
    • Meijer, A. E., Kronqvist, U.-S. E., Lewensohn, R. and Marms-Gingdahl, M. (1998) RBE for the induction of apoptosis in human peripheral lymphocytes exposed in vitro to high-LET radiation generated by accelerated nitrogen ions. Int. J. Radiat. Biol. 73: 169-177.
    • (1998) Int. J. Radiat. Biol. , vol.73 , pp. 169-177
    • Meijer, A.E.1    Kronqvist, U.-S.E.2    Lewensohn, R.3    Marms-Gingdahl, M.4
  • 17
    • 0026648674 scopus 로고
    • Identification of programmed death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli, Y., Sherman, Y.S. and Ben-Sasson, S. (1992) Identification of programmed death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119: 493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.S.2    Ben-Sasson, S.3
  • 18
    • 0031422897 scopus 로고    scopus 로고
    • Quantitative comparison of in situ methods for detecting apoptosis induced by X ray irradiation in mouse thymus
    • Fujita, K., Ohyama, H. and Yamada, T. (1997) Quantitative comparison of in situ methods for detecting apoptosis induced by X ray irradiation in mouse thymus. Histochem. J. 29: 823-830.
    • (1997) Histochem. J. , vol.29 , pp. 823-830
    • Fujita, K.1    Ohyama, H.2    Yamada, T.3
  • 19
    • 0040340739 scopus 로고    scopus 로고
    • Biphasic induction of apoptosis in the spleen after fractionated exposure of mice to very low doses of ionizing radiation
    • edited by T. Yamada and Y. Hashimoto (Business Center for Academic Societies, Japan)
    • Fujita, K., Ohtomi, M., Ohyama, H. and Yamada, T. (1998) Biphasic induction of apoptosis in the spleen after fractionated exposure of mice to very low doses of ionizing radiation. In: Apoptosis; Its role and mechanism, edited by T. Yamada and Y. Hashimoto (Business Center for Academic Societies, Japan), pp. 201-218.
    • (1998) Apoptosis; Its Role and Mechanism , pp. 201-218
    • Fujita, K.1    Ohtomi, M.2    Ohyama, H.3    Yamada, T.4
  • 20
    • 0028168643 scopus 로고
    • p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
    • Kemp, C. J., Wheldon, T. and Balmain, A. (1994) p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nature Genet. 8: 66-69.
    • (1994) Nature Genet. , vol.8 , pp. 66-69
    • Kemp, C.J.1    Wheldon, T.2    Balmain, A.3
  • 21
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt, M. S., Bennett, W. P., Hollstein, M. and Harris, C. C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54: 4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 22
    • 0033517244 scopus 로고    scopus 로고
    • Akt is more than just a bad kinase
    • Khwaja, A. (1999) Akt is more than just a Bad kinase. Nature 401: 33-34.
    • (1999) Nature , vol.401 , pp. 33-34
    • Khwaja, A.1
  • 23
    • 0032962641 scopus 로고    scopus 로고
    • Requirement of ATM in phosphorylation of the human p53 protein at serine 15
    • Nakagawa, K., Taya, Y., Tamai, K. and Yamaizumi, M. (1999) Requirement of ATM in phosphorylation of the human p53 protein at serine 15. Mol. Cell. Biol. 19: 2828-2834.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2828-2834
    • Nakagawa, K.1    Taya, Y.2    Tamai, K.3    Yamaizumi, M.4
  • 24
    • 0032950961 scopus 로고    scopus 로고
    • Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells
    • Zhao, Q. -L., Kondo, T., Noda, A. and Fujiwara, Y., 1999, Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells. Int. J. Radiat. Biol. 75: 493-504.
    • (1999) Int. J. Radiat. Biol. , vol.75 , pp. 493-504
    • Zhao, Q.-L.1    Kondo, T.2    Noda, A.3    Fujiwara, Y.4
  • 25
    • 0040340744 scopus 로고    scopus 로고
    • Threshold effects in radiation risks arising from concerted DNA repair and apoptosis
    • in press
    • Kondo, S. (2000) Threshold effects in radiation risks arising from concerted DNA repair and apoptosis. Proc. 11th Int. Congr. Radiat. Res., Radiat. Res. (in press).
    • (2000) Proc. 11th Int. Congr. Radiat. Res., Radiat. Res.
    • Kondo, S.1
  • 26
    • 0033594509 scopus 로고    scopus 로고
    • Gatekeepers of recombination
    • Haber, J. E. (1999) Gatekeepers of recombination. Nature 398: 665-666.
    • (1999) Nature , vol.398 , pp. 665-666
    • Haber, J.E.1
  • 28
    • 0029858143 scopus 로고    scopus 로고
    • V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
    • Guidos, C. J., Williams, C. J., Grandal, I., Knowles, G., Huan, M. T. F. and Danska, J. S. (1996) V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev. 10: 2038-2054.
    • (1996) Genes Dev. , vol.10 , pp. 2038-2054
    • Guidos, C.J.1    Williams, C.J.2    Grandal, I.3    Knowles, G.4    Huan, M.T.F.5    Danska, J.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.