Regulated expression of HIV-1 Rev function in mammalian cell lines

Canadian Journal of Microbiology

Volumn 45, Issue 6, 1999, Pages 480-490

  Swenarchuk, Lauren ^a   Harakidas, Penelope ^b   Cochrane, Alan ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Rev; Rev function; Tamoxifen; Tetracyline regulated transcription; Threshold effects

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; ESTROGEN RECEPTOR; HYBRID PROTEIN; REV PROTEIN; TAMOXIFEN; TETRACYCLINE; VIRUS ENVELOPE PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS REPLICATION;

ANIMALIA; CHRYSOMELIDAE; COLEOPTERA; FELIS CATUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA; PHRATORA; PHRATORA CALIFORNICA; POPULUS; POPULUS BALSAMIFERA SUBSP. TRICHOCARPA; RNA VIRUSES;

EID: 0040294688     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/w99-011     Document Type: Article

References (48)

1. Bogerd, H., Fridell, R., Madore, S., and Cullen, B. 1995. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell, 82: 485-494.
2. Butera, S., Roberts, B., Lam, L., Hodge, T., and Folks, T. 1994. Human immunodeficiency virus type 1 RNA expression by four chronically infected cell lines indicates multiple mechanisms of latency. J. Virol. 68: 2726-2730.
3. Charpentier, B., Stutz, F., and Rosbash, M. 1997. A dynamic in vivo view of the HIV-1 Rev-RRE interaction. J. Mol. Biol. 266: 950-962.
4. Cochrane, A.W., Chen, C.-H., and Rosen, C. 1990a. Specific interaction of the HIV Rev transactivator protein with a structured region in the env mRNA. Proc. Natl. Acad. Sci. U.S.A. 87: 1198-1201.
5. Cochrane, A.W., Perkins, A., and Rosen, C.A. 1990b. Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function. J. Virol. 64: 881-885.
6. Cohen, J. 1992.Glucocorticoid-induced apoptosis in the thymus. Semin. Immunol. 4: 363-369.
7. Cook, K.S., Fisk, G.J., Hauber, J., Usman, N., Daly, T.J., and Rusche, J.R. 1991. Characterization of HIV-1 Rev protein: binding stoichiometry and minimal RNA substrate. Nucleic Acids Res. 19: 1577-1583.
8. Emerman, M., Vazeux, R., and Peden, K. 1989. The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization. Cell, 57: 1155-1165.
9. Feinberg, M.B., Jarrett, R.F., Aldovini, A., Gallo, R.C., and Wong-Staal, F. 1986. HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA. Cell, 46: 807-817.
10. Felber, B.K., Hadzopoulou-Cladaras, M., Cladaras, C., Copeland, T., and Pavlakis, G.N. 1989. The rev protein of HIV-1 affects the stability and transport of the viral mRNA. Proc. Natl. Acad. Sci. U.S.A. 86: 1495-1499.
11. Fischer, U., Huber, J., Boelens, W., Mattaj, I., and Luhrmann, R. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific RNAs. Cell, 82: 475-483.
12. Fornerod, M., Ohno, M., Yoshida, M., and Mattaj, I. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell, 90: 1051-1060.
13. Fritz, C., Zapp, M., and Green, M. 1995. A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature (London), 376: 530-533.
14. Garvy, B., Telford, W., King, L., and Fraker, P. 1993. Glucocorticoids and irradiation-induced apoptosis in normal murine bone marrow B-lineage lymphocytes as determined by flow cytometry. Immunology, 79: 270-277.
15. Gorman, C.M., Moffatt, L.F., and Howard, B.H. 1982. Recombinant genomes which express chloramphenicol acetyl transferase in mammalian cells. Mol. Cell. Biol. 2: 1044-1051.
16. Gossen, M., and Bujard, H. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 89: 5547-5551.
17. Hadzopoulou-Cladaras, M., Felber, B.K., Cladaras, C., Athanassopoulos, A., Tse, A., and Pavlakis, G.N. 1989. The Rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J. Virol. 63: 1265-1274.
18. Hammarskjöld, M.L., Heimer, J., Hammarskjöld, B., Sangwan, I., Albert, L., and Rekosh, D. 1989. Regulation of human immunodeficiency virus env expression by the Rev gene product. J. Virol. 63: 1959-1966.
19. Heaphy, S., Dingwall, C., Ernberg, I., Gait, M.J., Green, S.M., Karn, J., Lowe, A.D., Singh, M., and Skinner, M.A. 1990. HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element. Cell, 60: 685-693.
20. Hope, T.J., Huang, X., McDonald, D., and Parslow, T.G. 1990. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping of cryptic functions of the arginine-rich motif. Proc. Natl. Acad. Sci. U.S.A. 87: 7787-7791.
21. Iacampo, S., and Cochrane, A. 1996. Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA. J. Virol. 70: 8332-8339.
22. Iwai, S., Pritchard, C., Mann, D., Karn, J., and Gait, M. 1992. Recognition of the high affinity binding site in the rev-responsive element RNA by the human immunodeficiency virus type 1 Rev protein. Nucleic Acids Res. 20: 6465-6472.
23. Kim, S., Byrn, R., Groopman, J., and Baltimore, D. 1989. Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. J. Virol. 63: 3708-3713.
24. Kjems, J., Brown, M., Chang, D., and Sharp, P. 1991. Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev responsive element. Proc. Natl. Acad. Sci. U.S.A. 88: 683-687.
25. Kubota, S., Siomi, H., Satoh, T., Endo, S., Maki, M., and Hatanaka, M. 1989. Functional similarity of HIV-1 Rev and HTLV-1 Rex proteins: identification of a new nucleolar-targeting signal in Rev protein. Biochem. Biophys. Res. Commun. 162: 963-970.
26. Littlewood, T., Hancock, D., Danielian, P., Parker, M., and Evan, G. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23: 1686-1690.
27. Malim, M.H., and Cullen, B.R. 1991. HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency. Cell, 65: 241-248.
28. Malim, M., and Cullen, B. 1993. Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. Mol. Cell. Biol. 13: 6180-6189.
29. Malim, M.H., Bohnlein, S., Hauber, J., and Cullen, B.R. 1989a. Functional dissection of the HIV-1 rev trans-activator - derivation of a trans-dominant represser of rev function. Cell, 58: 205-214.
30. Malim, M.H., Hauber, J., Le, S.-Y., Maizel, J.V., and Cullen, B.R. 1989b. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature (London), 338: 254-257.
31. Mann, R., Mulligan, R., and Baltimore, D. 1983. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell, 33: 153-159.
32. Mergenstern, J., and Land, H. 1990. Advanced mammalian gene transfer: high titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18: 3587-3597.
33. Meyer, B., Meinkoth, J., and Malim, M. 1996. Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals. J. Virol. 70: 2350-2359.
34. Michael, N., Morrow, P., Mosca, J., Vahey, M., Burke, D., and Redfield, R. 1991. Induction of human immunodeficiency virus type 1 expression in chronically infected cells is associated primarily with a shift in RNA splicing patterns. J. Virol. 65: 1291-1303.
35. Michael, N., Mo, T., Merzouki, A., O'Shaughnessy, M., Oster, C., Burke, D., Redfield, R., Birx, D., and Cassol, S. 1995. Human immunodeficiency virus type 1 cellular RNA load and splicing patterns predict disease progression in a longitudinal cohort. J. Virol. 69: 1868-1877.
36. Miller, A., and Buttimore, C. 1986. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol. Cell. Biol. 6: 2895-2902.
37. Olsen, H.S., Cochrane, A.W., Dillon, P.J., Nalin, C.M., and Rosen, C.A. 1990. Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent upon multimer formation mediated through a basic stretch of amino acids. Genes Dev. 4: 1357-1364.
38. Perkins, A., Cochrane, A.W., Ruben, S.M., and Rosen, C.A. 1989. Structural and functional characterization of the human immunodeficiency virus Rev protein. J. Acquir. Immune. Defic. Syndr., 2: 256-263.
39. Pomerantz, R., Trono, D., Feinberg, M., and Baltimore, D. 1990. Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency. Cell, 61: 1271-1276.
40. Pomerantz, R., Seshamma, T., and Trono, D. 1992. Efficient replication of human immunodeficiency virus type 1 requires threshold level of Rev: potential implications for latency. J. Virol. 66: 1809-1813.
41. Rosen, C.A., Terwilliger, E., Dayton, A., Sodroski, J.G., and Haseltine, W.A. 1988. Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus. Proc. Natl. Acad. Sci. U.S.A. 85: 2071-2075.
42. Ruhl, M., Himmelspach, M., Bahr, G., Hammarschmid, F., Jaksche, H., Wolff, B., Aschauer, H., Farrington, G., Probst, H., Bevec, D., and Hauber, J. 1993. Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type I Rev activation domain mediating trans-Activation. J. Cell Biol. 123: 1309-1320.
43. Seshamma, T., Bagrasa, D., Trono, D., Baltimore, D., and Pomerantz, R. 1992. Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. U.S.A. 89: 10 663-10 667.
44. Sodroski, J., Goh, W.C., Rosen, C., Dayton, A., Terwilliger, E., and Haseltine, W.A. 1986. A second post-transcriptional trans-activator gene required for the HTLV-III replication. Nature (London), 321: 412-417.
45. Stade, K., Ford, C., Guthrie, C., and Weis, K. 1997. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell, 90: 1041-1050.
46. Wolff, B., Sanglier, J., and Wang, Y. 1997. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol. 4: 139-147.
47. Zapp, M., and Green, M. 1989. Sequence-specific RNA binding by the HIV-1 Rev protein. Nature (London), 342: 714-716.
48. Zapp, M.L., Hope, T.J., Parslow, T.G., and Green, M.R. 1991. Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif. Proc. Natl. Acad. Sci. U.S.A. 88: 7734-7738.