Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA

Journal of Virology

Volumn 70, Issue 12, 1996, Pages 8332-8339

  Iacampo, Sandra ^a   Cochrane, Alan ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DACTINOMYCIN; MESSENGER RNA; REV PROTEIN; STRUCTURAL PROTEIN;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; RNA SYNTHESIS;

EID: 0029961361     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.12.8332-8339.1996     Document Type: Article

References (60)

1. Bogerd, H., R. Fridell, S. Madore, and B. Cullen. 1995. Identification of a novel cellular cotactor for the Rev/Rex class of retroviral regulatory proteins. Cell 82:485-494.
2. Chang, D. D., and P. A. Sharp. 1989 Regulation by HIV Rev depends upon recognition of splice sites. Cell 59:789-795.
3. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
4. Cochrane, A. W., C.-H. Chen, and C. Rosen. 1990. Specific interaction of the HIV Rev transactivator protein with a structured region in the env mRNA. Proc. Natl. Acad. Sci. USA 87:1198-1201.
5. Cochrane, A. W., K. S. Jones, S. Beidas, P. J. Dillon, A. M. Skalka, and C. A. Rosen. 1991. Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expression. J. Virol. 65:5305-5313.
6. Cochrane, A. W., A. Perkins, and C. A. Rosen. 1990. Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function. J. Virol. 64:881-885.
7. Cullen, B. R. 1988. Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol. 152:684-704.
8. Cullen, B. R., and W. C. Greene. 1990. Functions of the auxiliary gene products of the human immunodeficiency virus type 1. Virology 178:1-5.
9. D'Agostino, D., V. Ciminale, G. Pavlakis, and L. Chiecho-Bianchi. 1995. Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention. AIDS Res. Hum. Retroviruses 11:1063-1070.
10. Daly, T., K. Cook, G. Gray, T. Maione, and J. Rusche. 1989. Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro. Nature (London) 342:816-819.
11. Dinter, H., and H. Hauser. 1987. Superinduction of the human interferon-beta promoter. EMBO J. 6:599-604.
12. Edwards, D., and L. Mahadevan. 1992. Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three different mechanisms: lack of evidence for labile repressors. EMBO J. 11:2415-2424.
13. Emerman, M., R. Vazeux, and K. Peden. 1989. The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization. Cell 57:1155-1165.
14. Felber, B. K., M. Hadzopoulou-Cladaras, C. Cladaras, T. Copeland, and G. N. Pavlakis. 1989. The rev protein of HIV-1 affects the stability and transport of the viral mRNA. Proc. Natl. Acad. Sci. USA 86:1495-1499.
15. Fischer, U., J. Huber, W. Boelens, I. Mattaj, and R. Luhrmann. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific RNAs. Cell 82:475-483.
16. Fritz, C., M. Zapp, and M. Green. 1995. A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature (London) 376:530-533.
17. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
18. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells bv tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
19. Granick, D. 1975. Nucleolar necklaces in chick embryo fibroblasts. 1. Formation of necklaces by dichlororibobenzimidazole and other adenosine analogs that decrease RNA synthesis and degrade preribosomes. J. Cell Biol. 65:398-417.
20. Greenberg, M., and E. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (London) 311:433-438.
21. Hadzopoulou-Cladaras, M., B. K. Felber, C. Cladaras, A. Athanassopoulos, A. Tse, and G. N. Pavlakis. 1989. The Rev (Trs/Art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J. Virol. 63:1265-1274.
22. Hammarskjöld, M. L., J. Heimer, B. Hammarskjöld, I. Sangwan, L. Albert, and D. Rekosh. 1989. Regulation of human immunodeficiency virus env expression by the rev gene product. J. Virol. 63:1959-1966.
23. Heaphy, S., C. Dingwall, I. Ernberg, M. J. Gait, S. M. Green, J. Karn, A. D. Lowe, M. Singh, and M. A. Skinner. 1990. HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element. Cell 60:685-693.
24. Holland, S. M., N. Ahmad, R. K. Maitra, P. Wingfield, and S. Venkatesan. 1990. Human immunodeficiency virus Rev protein recognizes a target sequence in Rev-responsive element RNA within the context of RNA secondary structure. J. Virol. 64:5966-5975.
25. Hope, T. J., X. Huang, D. McDonald, and T. G. Parslow. 1990. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping of cryptic functions of the arginine-rich motif. Proc. Natl. Acad. Sci. USA 87:7787-7791.
26. Kalland, K., A. M. Szilvay, K. Brokstad, W. Saetrevik, and G. Haukenes. 1994. The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments. Mol. Cell. Biol. 14:7436-7444.
27. Kriegler, M. 1990. Gene transfer and expression: a laboratory manual. Stockton Press. New York.
28. Kubota, S., H. Siomi, T. Satoh, S. Endo, M. Maki, and M. Hatanaka. 1989. Functional similarity ot HIV-1 Rev and HTLV-1 Rex proteins: identification of a new nucleolar-targeting signal in Rev protein. Biochem. Biophys. Res. Commun. 162:963-970
29. Lebendiker, M. A., C. Tal, S. Dror, S. Pilo, A. Eilon, Y. Banai, and R. Kaempfer. 1987. Superinduction of the human gene encoding immune interferon. EMBO J. 6:585-589.
30. Lu, X., J. Heimer, D. Rekosh, and M.-L. Hammarskjold. 1990. U1 small nuclear RNA plays a direct role in the formation of a rev-regulated human immunodeficiency virus env mRNA that remains unspliced. Proc. Natl. Acad. Sci. USA 87:7598-7602.
31. Maldarelli, F., M. A. Martin, and K. Strebel. 1991. Identification of post-transcriptionally active inhibitory sequences in human immunodeficiency virus type I RNA: novel level of gene regulation. J. Virol. 65:5732-5743.
32. Malim, M., and B. Cullen. 1993. Rev and the fate of Pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. Mol. Cell. Biol. 13:6180-6189.
33. Malim, M. H., S. Bohnlein, J. Hauber, and B. R. Cullen. 1989. Functional dissection of the HIV-1 rev trans-activator - derivation of a trans-dominant repressor of rev function. Cell 58:205-214.
34. Malim, M. H., J. Hauber, S.-Y. Le, J. V. Maizel, and B. R. Cullen. 1989. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature (London) 338:254-257.
35. Malim, M. H., L. S. Tiley, D. F. McCarn, J. R. Rusche, J. Hauber, and B. R. Cullen. 1990. HIV-1 structural gene expression requires binding of the Rev trars-activator to its RNA target sequence. Cell 60:675-683.
36. Mermer, B., B. Felber, M. Campbell, and G. N. Pavlakis. 1990. Identification of transdominant HIV-1 Rev protein mutants by direct transfer of bacterially produced proteins into human cells. Nucleic Acids Res. 18:2037-2044.
37. Meyer, B., and M. Malim. 1994. The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev. 8:1538-1547.
38. Meyer, B., J. Meinkoth, and M. Malim. 1996. Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals. J. Virol. 70:2350-2359.
39. Olsen, H., P. Nelbock, A. Cochrane, and C. Rosen. 1990. Secondary structure is the major determinant for interaction of HIV Rev protein with RNA. Science 247:845-848.
40. Olsen, H. S., A. W. Cochrane, P. J. Dillon, C. M. Nalin, and C. A. Rosen. 1990. Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent upon multimer formation mediated through a basic stretch of amino acids. Genes Dev. 4:1357-1364.
41. Perkins, A., A. W. Cochrane, S. M. Ruben, and C. A. Rosen. 1989. Structural and functional characterization of the human immunodeficiency virus rev protein. J. Acquired Immune Defic. Syndr. 2:256-263.
42. Perry, R., and D. Kelley. 1970. Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species. J. Cell Physiol. 76:127-140.
43. Richard, N., S. Iacampo, and A. Cochrane. 1994. HIV-1 Rev is capable of shuttling between the nucleus and cytoplasm. Virology 204:123-131.
44. Ringold, G., B. Dieckmann, J. Vannice, M. Trahey, and F. McCormick. 1984. Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells. Proc. Natl. Acad. Sci. USA 81:3964-3968.
45. Ringold, G. M., B. Dieckmann, J. L. Vannice, M. Trahey, and F. McCormick. 1984. Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells. Proc. Natl. Acad. Sci. USA 81:3964-3968.
46. Rosen, C. A., E. Terwilliger, A. Dayton, J. G. Sodroski, and W. A. Haseltine. 1988. Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 85:2071-2075.
47. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
48. Schwartz, S., B. K. Felber, D. M. Benko, E.-M. Fenyo, and G. N. Pavlakis. 1990. Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1. J. Virol. 64:2519-2529.
49. Schwartz, S., B. K. Felber, E. V. Fenyo, and G. N. Pavlakis. 1990. Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs. J. Virol. 64:5448-5456.
50. Schwartz, S., B. K. Felber, and G. N. Pavlakis. 1992. Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decreases RNA stability and inhibit expression in the absence of Rev protein. J. Virol. 66:150-159.
51. Sehgal, P. B., and I. Tamm. 1978. Halogenated benzimidazole ribosides: novel inhibitors of RNA synthesis. Biochem. Pharmocol. 27:2475-2485.
52. Southgate, C., M. L. Zapp, and M. R. Green. 1990. Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein. Nature (London) 345:640-642.
53. Stauber, R., G. Gaitanaris, and G. Pavlakis. 1995. Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm. Virology 213:439-449.
54. Szilvay, A. M., K. Brokstad, R. Kopperud, G. Haukenes, and K.-H. Kalland. 1995. Nuclear export of the human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev is mediated by its activation domain and is blocked by transdominant negative mutants. J. Virol. 69:3315-3323.
55. Tan, Y., J. Armstrong, Y. Ke, and M. Ho. 1970. Regulation of cellular interferon production: enhancement by antimetabolites. Proc. Natl. Acad. Sci. USA 67:464-471.
56. Tiley, L., S. Madore, M. Malim, and B. Cullen. 1992. The VP16 transcription activation domain is functional when targetted to a promoter-proximal RNA sequence. Genes Dev. 6:2077-2087.
57. Trono, D. 1995. HIV accessory proteins: Leading roles for the supportive cast. Cell 82:189-192.
58. Wolff, B., G. Cohen, J. Hauber, D. Meshcheryakova, and C. Rabeck. 1995. Nucleocytoplasmic transport of the Rev protein of human immunodeficiency virus type 1 is dependent on the activation domain of the protein. Exp. Cell Res. 217:31-41.
59. Zapp, M., and M. Green. 1989. Sequence-specific RNA binding by the HIV-1 Rev protein. Nature (London) 342:714-716.
60. Zapp, M. L., T. J. Hope, T. G. Parslow, and M. R. Green. 1991. Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif. Proc. Natl. Acad. Sci. USA 88:7734-7738.