Effect of 2'-OH acetylation on the bioactivity and conformation of 7-O-[N-(4'-fluoresceincarbonyl)-L-alanyl]taxol. A NMR-fluorescence microscopy study

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 10, 1998, Pages 1857-1863

  Jiménez Barbero, Jesús ^a   Souto, André A ^a   Abal, Miguel ^b   Barasoain, Isabel ^b   Evangelio, Juan A ^b   Acuña, A Ulises ^c   Andreu, José M ^b   Amat Guerri, Francisco ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

Fluorescence; Microtubule probes; NMR; Paclitaxel structure activity relationship

Indexed keywords

7 O [N (4 FLUORESCEINCARBONYL)ALANYL]TAXOL; FLUORESCENT DYE; TAXOID; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ACETYLATION; DRUG ACTIVITY; DRUG CONFORMATION; FLUORESCENCE MICROSCOPY; FLUORESCENCE SPECTROSCOPY; MICROTUBULE; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ACETYLATION; ANIMALS; CELLS, CULTURED; CYTOSKELETON; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PACLITAXEL; TAXOIDS; TUBULIN;

EID: 0040283025     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00149-7     Document Type: Article

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