메뉴 건너뛰기




Volumn 27, Issue 11, 1999, Pages 2399-2406

The effect of acidified enteral feeds on gastric colonization in critically ill patients: Results of a multicenter randomized trial

Author keywords

Acidemia; Critical care; Enteral nutrition; Gastric colonization; Gastric pH; Nosocomial pneumonia; Randomized trial

Indexed keywords

ACIDIFICATION; ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; BACTERIAL COLONIZATION; CANDIDA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; DOUBLE BLIND PROCEDURE; ENTERIC FEEDING; ENTEROBACTER; ENTEROCOCCUS; ESCHERICHIA COLI; FEMALE; HAEMOPHILUS; HUMAN; KLEBSIELLA; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS; RANDOMIZED CONTROLLED TRIAL; SERRATIA; STAPHYLOCOCCUS AUREUS; STOMACH; STOMACH PH;

EID: 0038983091     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199911000-00013     Document Type: Article
Times cited : (81)

References (41)
  • 1
    • 0026317030 scopus 로고
    • Incidence, etiology and outcome of nosocomial pneumonia in mechanically ventilated patients
    • 1. Rello J, Quintana E, Ausine V, et al: Incidence, etiology and outcome of nosocomial pneumonia in mechanically ventilated patients. Chest 1991; 100:439-444.
    • (1991) Chest , vol.100 , pp. 439-444
    • Rello, J.1    Quintana, E.2    Ausine, V.3
  • 2
    • 0027466159 scopus 로고
    • Nosocomial pneumonia in ventilated patients: A cohort study evaluation of attributable mortality and hospital stay
    • 2. Fagon JY, Chastre J, Hance A, et al: Nosocomial pneumonia in ventilated patients: A cohort study evaluation of attributable mortality and hospital stay. Am J Med 1993; 94:281-288
    • (1993) Am J Med , vol.94 , pp. 281-288
    • Fagon, J.Y.1    Chastre, J.2    Hance, A.3
  • 3
    • 0026014715 scopus 로고
    • The gastropulmonary route of infection: Fact or fiction
    • 3. Tryba M: The gastropulmonary route of infection: Fact or fiction. Am J Med 1991; 91(Suppl 2A):135S-146S
    • (1991) Am J Med , vol.91 , Issue.SUPPL. 2A
    • Tryba, M.1
  • 4
    • 0026582655 scopus 로고
    • Gastric colonization and nosocomial pneumonia: Evidence for causation
    • 4. Heyland DK, Mandell LA: Gastric colonization and nosocomial pneumonia: Evidence for causation. Chest 1992; 101:187-193
    • (1992) Chest , vol.101 , pp. 187-193
    • Heyland, D.K.1    Mandell, L.A.2
  • 5
    • 0024536918 scopus 로고
    • Nosocomial pneumonia in the intubated patient: Role of gastric colonization
    • 5. Craven DE, Daschner FD: Nosocomial pneumonia in the intubated patient: Role of gastric colonization. Eur J Clin Microbiol Infect Dis 1989; 8:40-50
    • (1989) Eur J Clin Microbiol Infect Dis , vol.8 , pp. 40-50
    • Craven, D.E.1    Daschner, F.D.2
  • 6
    • 0020043864 scopus 로고
    • Aspiration of gastric bacteria in antacid-treated patients: A frequent cause of post-operative colonization of the airway
    • 6. Du Moulin GC, Hedley-Whyte J, Paterson DJ, et al: Aspiration of gastric bacteria in antacid-treated patients: A frequent cause of post-operative colonization of the airway. Lancet 1982; i:242-245
    • (1982) Lancet , vol.1 , pp. 242-245
    • Du Moulin, G.C.1    Hedley-Whyte, J.2    Paterson, D.J.3
  • 7
    • 0001886180 scopus 로고
    • Gastric colonization in patients receiving antacids and mechanical ventilation: A mechanism for pharyngeal colonization
    • 7. Goularte TA, Lichtenberg DA, Craven DE: Gastric colonization in patients receiving antacids and mechanical ventilation: A mechanism for pharyngeal colonization. Am J Infect Control 1986; 14:88
    • (1986) Am J Infect Control , vol.14 , pp. 88
    • Goularte, T.A.1    Lichtenberg, D.A.2    Craven, D.E.3
  • 8
    • 0023957103 scopus 로고
    • Stress ulcer prophylaxis and ventilation pneumonia: Prevention by antibacterial cytoprotective agents
    • 8. Daschner F, Kappstein I, Engels I, et al: Stress ulcer prophylaxis and ventilation pneumonia: Prevention by antibacterial cytoprotective agents. Infect Control Hosp Epidemiol 1988; 9:59-65
    • (1988) Infect Control Hosp Epidemiol , vol.9 , pp. 59-65
    • Daschner, F.1    Kappstein, I.2    Engels, I.3
  • 9
    • 0023612057 scopus 로고
    • Nosocomial pneumonia in intubated patients given sucralfate as compared with antacids or histamine type 2 blockers
    • 9. Driks MR, Craven DE, Celli BR, et al: Nosocomial pneumonia in intubated patients given sucralfate as compared with antacids or histamine type 2 blockers. N Engl J Med 1987; 317:1376-1382
    • (1987) N Engl J Med , vol.317 , pp. 1376-1382
    • Driks, M.R.1    Craven, D.E.2    Celli, B.R.3
  • 10
    • 0023633735 scopus 로고
    • Risk of acute stress bleeding and nosocomial pneumonia in ventilated intensive care unit patients: Sucralfate versus antacids
    • 10. Tryba M: Risk of acute stress bleeding and nosocomial pneumonia in ventilated intensive care unit patients: Sucralfate versus antacids. Am J Med 1987; 83:117-124
    • (1987) Am J Med , vol.83 , pp. 117-124
    • Tryba, M.1
  • 11
    • 0022652076 scopus 로고
    • Alteration of normal gastric flora in critical care patients receiving antacid and cimetidine therapy
    • 11. Donowitz GL, Page ML, Mileur BL, et al: Alteration of normal gastric flora in critical care patients receiving antacid and cimetidine therapy. Infect Control 1986; 7:23-26
    • (1986) Infect Control , vol.7 , pp. 23-26
    • Donowitz, G.L.1    Page, M.L.2    Mileur, B.L.3
  • 12
    • 0025285028 scopus 로고
    • Continuous enteral feeding: A major cause of pneumonia among ventilated intensive care unit patients
    • 12. Jacobs S, Chang RWS, Lee B, et al: Continuous enteral feeding: A major cause of pneumonia among ventilated intensive care unit patients. J Parenter Enteral Nutr 1990; 14: 353-356
    • (1990) J Parenter Enteral Nutr , vol.14 , pp. 353-356
    • Jacobs, S.1    Chang, R.W.S.2    Lee, B.3
  • 13
    • 0025106389 scopus 로고
    • Intermittent nasogastric feeding: A simple and effective method to reduce pneumonia among ventilated ICU patients
    • 13. Lee B, Chang RWS, Jacobs S: Intermittent nasogastric feeding: A simple and effective method to reduce pneumonia among ventilated ICU patients. Clin Intensive Care 1990; 1:100-102
    • (1990) Clin Intensive Care , vol.1 , pp. 100-102
    • Lee, B.1    Chang, R.W.S.2    Jacobs, S.3
  • 14
    • 0020160811 scopus 로고
    • Colonization of the gastric contents in critically ill patients
    • 14. Hillman KM, Riordan T, O'Farrel SM, et al: Colonization of the gastric contents in critically ill patients. Crit Care Mad 1982 10; 7:444-447
    • (1982) Crit Care Mad , vol.10 , Issue.7 , pp. 444-447
    • Hillman, K.M.1    Riordan, T.2    O'Farrel, S.M.3
  • 15
    • 0015319397 scopus 로고
    • Gastric acid barrier to ingested microorganisms in man: Studies in vitro and in vivo
    • 15. Giannella RA, Broitman SA, Zamcheck N: Gastric acid barrier to ingested microorganisms in man: Studies in vitro and in vivo. Gut 1972; 13:251-256
    • (1972) Gut , vol.13 , pp. 251-256
    • Giannella, R.A.1    Broitman, S.A.2    Zamcheck, N.3
  • 16
    • 0026778539 scopus 로고
    • Effect of acidified enteral feeds on gastric colonization in the critically ill patient
    • 16. Heyland DK, Bradley C, Mandell LA: Effect of acidified enteral feeds on gastric colonization in the critically ill patient. Crit Care Med 1992; 20:1388-1394
    • (1992) Crit Care Med , vol.20 , pp. 1388-1394
    • Heyland, D.K.1    Bradley, C.2    Mandell, L.A.3
  • 17
    • 0019861883 scopus 로고
    • The pathophysiology of stress ulcer disease
    • 17. Silen W, Mechay A, Sinison JNL: The pathophysiology of stress ulcer disease. World J Surg 1981; 5:165-174
    • (1981) World J Surg , vol.5 , pp. 165-174
    • Silen, W.1    Mechay, A.2    Sinison, J.N.L.3
  • 18
    • 0022256529 scopus 로고
    • APACHE II: A severity of diseases classification system
    • 18. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of diseases classification system. Crit Care Med 1985; 13: 818-829
    • (1985) Crit Care Med , vol.13 , pp. 818-829
    • Knaus, W.A.1    Draper, E.A.2    Wagner, D.P.3
  • 20
    • 0027474987 scopus 로고
    • Evaluation of clinical judgment and treatment of nosocomial pneumonia in ventilated patients
    • 20. Fagon JY, Chastre J, Hance AJ, et al: Evaluation of clinical judgment and treatment of nosocomial pneumonia in ventilated patients. Chest 1993; 103:547-553
    • (1993) Chest , vol.103 , pp. 547-553
    • Fagon, J.Y.1    Chastre, J.2    Hance, A.J.3
  • 21
    • 0029740788 scopus 로고    scopus 로고
    • The clinical and economic consequences of clinically important bleeding in critically ill patients
    • 21. Heyland DK, Gafni A, Griffith L, et al: The clinical and economic consequences of clinically important bleeding in critically ill patients. Clin Intensive Care 1996; 7:121-125
    • (1996) Clin Intensive Care , vol.7 , pp. 121-125
    • Heyland, D.K.1    Gafni, A.2    Griffith, L.3
  • 25
    • 0015325652 scopus 로고
    • The slowing of gastric emptying by four strong acids and three weak acids
    • 25. Hunt JN, Knox MT: The slowing of gastric emptying by four strong acids and three weak acids. J Physiol 1972; 222:187-208
    • (1972) J Physiol , vol.222 , pp. 187-208
    • Hunt, J.N.1    Knox, M.T.2
  • 26
    • 0028316668 scopus 로고
    • The stomach is not a source for colonization of the upper respiratory tract and pneumonia in ICU patients
    • 26. Bonten MJM, Gaillard CA, van Tiel FH, et al: The stomach is not a source for colonization of the upper respiratory tract and pneumonia in ICU patients. Chest 1994; 105:878-884
    • (1994) Chest , vol.105 , pp. 878-884
    • Bonten, M.J.M.1    Gaillard, C.A.2    Van Tiel, F.H.3
  • 27
    • 0026803407 scopus 로고
    • Uncertain relevance of gastric colonization in the seriously ill
    • 27. Cade JF, McOwat E, Siganporia R, et al: Uncertain relevance of gastric colonization in the seriously ill. Intensive Care Med 1992; 18:210-217
    • (1992) Intensive Care Med , vol.18 , pp. 210-217
    • Cade, J.F.1    McOwat, E.2    Siganporia, R.3
  • 28
    • 0024314236 scopus 로고
    • Role of gastric colonization in nosocomial infections and endotoxemia: A prospective study in neurosurgical patients on mechanical ventilation
    • 28. Reusser P, Zimmerli W, Scheidegger D, et al: Role of gastric colonization in nosocomial infections and endotoxemia: A prospective study in neurosurgical patients on mechanical ventilation. J Infect Dis 1989; 160:414-421
    • (1989) J Infect Dis , vol.160 , pp. 414-421
    • Reusser, P.1    Zimmerli, W.2    Scheidegger, D.3
  • 29
    • 0030719853 scopus 로고    scopus 로고
    • Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit: A prospective study based on genomic DNA analysis
    • 29. Garrouste-Orgeas M, Chevret S, Arlet G, et al: Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit: A prospective study based on genomic DNA analysis. Am J Respir Crit Care Med 1997; 156:1647-1655
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1647-1655
    • Garrouste-Orgeas, M.1    Chevret, S.2    Arlet, G.3
  • 30
    • 0024557527 scopus 로고
    • Patterns and routes of tracheobronchial colonization in the seriously ill
    • 30. Niederman MS, Mantovani R, Schoch P, et al: Patterns and routes of tracheobronchial colonization in the seriously ill. Chest 1989; 95:155-161
    • (1989) Chest , vol.95 , pp. 155-161
    • Niederman, M.S.1    Mantovani, R.2    Schoch, P.3
  • 31
    • 0028273509 scopus 로고
    • Selective decontamination of the digestive tract: An overview
    • 31. Heyland D, Cook DJ, Jaeschke R, et al: Selective decontamination of the digestive tract: An overview. Chest 1994; 105: 1221-1229
    • (1994) Chest , vol.105 , pp. 1221-1229
    • Heyland, D.1    Cook, D.J.2    Jaeschke, R.3
  • 32
    • 0032565412 scopus 로고    scopus 로고
    • Effectiveness of antibiotic prophylaxis in critically ill patients: Systematic review of randomized controlled trials
    • 32. D'Amico R, Pifferi S, Leonetti C, et al: Effectiveness of antibiotic prophylaxis in critically ill patients: Systematic review of randomized controlled trials. BMJ 1998; 315:1275-1285
    • (1998) BMJ , vol.315 , pp. 1275-1285
    • D'Amico, R.1    Pifferi, S.2    Leonetti, C.3
  • 33
    • 0027202258 scopus 로고
    • Meta-analyses of randomized controlled trials of selective decontamination of the digestive tract
    • 33. Selective Decontamination of the Digestive Tract Trialist's Collaborative Group: Meta-analyses of randomized controlled trials of selective decontamination of the digestive tract. BMJ 1993; 307:525-532
    • (1993) BMJ , vol.307 , pp. 525-532
  • 34
    • 0028268933 scopus 로고
    • The role of selective digestive tract decontamination on mortality and respiratory tract infections: A meta-analysis
    • 34. Kollef MH: The role of selective digestive tract decontamination on mortality and respiratory tract infections: A meta-analysis. Chest 1994; 105:1101-1108
    • (1994) Chest , vol.105 , pp. 1101-1108
    • Kollef, M.H.1
  • 35
    • 0023957103 scopus 로고
    • Stress ulcer prophylaxis and ventilation pneumonia: Prevention by antibacterial cytoprotective agents
    • 35. Daschner F, Kappstein I, Engels I, et al: Stress ulcer prophylaxis and ventilation pneumonia: Prevention by antibacterial cytoprotective agents. Infect Control Hosp Epidemiol 1988; 9:59-65
    • (1988) Infect Control Hosp Epidemiol , vol.9 , pp. 59-65
    • Daschner, F.1    Kappstein, I.2    Engels, I.3
  • 36
    • 0030029997 scopus 로고    scopus 로고
    • Stress ulcer prophylaxis in the critically ill: Resolving discordant meta-analyses
    • 36. Cook DJ, Reeve BK, Guyatt GH, et al: Stress ulcer prophylaxis in the critically ill: Resolving discordant meta-analyses. JAMA 1996; 275:308-314
    • (1996) JAMA , vol.275 , pp. 308-314
    • Cook, D.J.1    Reeve, B.K.2    Guyatt, G.H.3
  • 37
    • 6844236394 scopus 로고    scopus 로고
    • A comparison of sucralfate and ranitidine for prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation
    • 37. Cook DJ, Guyatt GH, Marshall J, et al: A comparison of sucralfate and ranitidine for prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. N Engl J Med 1998; 338:791-797
    • (1998) N Engl J Med , vol.338 , pp. 791-797
    • Cook, D.J.1    Guyatt, G.H.2    Marshall, J.3
  • 38
    • 23444457922 scopus 로고
    • Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer: A randomized controlled trial
    • 38. Prod'hom G, Leuenberger P, Koerfer J, et al: Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer: A randomized controlled trial. Ann Intern Med 1994; 120:653-662
    • (1994) Ann Intern Med , vol.120 , pp. 653-662
    • Prod'hom, G.1    Leuenberger, P.2    Koerfer, J.3
  • 39
    • 0028567869 scopus 로고
    • Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit: A randomized, controlled, single-blind study
    • 39. Ben-Menachem T, Fogel R, Patel RV, et al: Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit: A randomized, controlled, single-blind study. Ann Intern Med 1994; 121:568-575
    • (1994) Ann Intern Med , vol.121 , pp. 568-575
    • Ben-Menachem, T.1    Fogel, R.2    Patel, R.V.3
  • 40
    • 0029936285 scopus 로고    scopus 로고
    • Intermittent enteral feeding in mechanically ventilated patients: The effect on gastric pH and gastric cultures
    • 40. Spilker CA, Hinthorn DR, Pingleton SK: Intermittent enteral feeding in mechanically ventilated patients: The effect on gastric pH and gastric cultures. Chest 1996; 110:243-248
    • (1996) Chest , vol.110 , pp. 243-248
    • Spilker, C.A.1    Hinthorn, D.R.2    Pingleton, S.K.3
  • 41
    • 0029781075 scopus 로고    scopus 로고
    • Intermittent enteral feeding: The influence on respiratory and digestive tract colonization in mechanically ventilated intensive care unit patients
    • 41. Bonten MJM, Gaillard CA, van der Hulst R, et al: Intermittent enteral feeding: The influence on respiratory and digestive tract colonization in mechanically ventilated intensive care unit patients. Am J Respir Crit Care Med 1996; 154:394-399
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 394-399
    • Bonten, M.J.M.1    Gaillard, C.A.2    Van Der Hulst, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.