Changes in reproductive organs of female rats treated with bisphenol A during the neonatal period

Reproductive Toxicology

Volumn 17, Issue 3, 2003, Pages 283-288

  Kato, Hideo ^a,b   Ota, Takao ^a   Furuhashi, Tadakazu ^a   Ohta, Yasuhiko ^c,d   Iguchi, Taisen ^b,d  

^a Nihon Bioresearch Inc   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Bisphenol A; Early vaginal opening; Female rat; Irregular estrous cycles; Lack of corpora lutea; Neonatal period; Polycystic ovarian follicles; Reproductive organ

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ESTRADIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; FEMALE GENITAL SYSTEM; GYNECOLOGIC DISEASE; NEWBORN; NONHUMAN; OVARIECTOMY; OVARY POLYCYSTIC DISEASE; RAT; UTERUS FLUID; WEIGHT GAIN;

ANIMALIA;

EID: 0038823673     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(03)00002-9     Document Type: Article

References (22)

1. Colborn T, vom Saal FS, Soto AM. Developmental effects of endocrine disrupting chemicals in wildlife and humans. Environ Health Perspect 1993;101:378-84.
2. Colborn T. Environmental estrogens: health implications for humans and wildlife. Environ Health Perspect 1995;103:135-6.
3. Guillette LJ, Pickford DB, Crain DA, Rooney AA, Franklin RH. Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment. Gen Comp Endocrinol 1996;101:32-42.
4. Kuiper GGJM, Carlsson B, Glandien K, Enmark E, Haggblad J, Nilsson S, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 1997;138:863-70.
5. Nishihara T, Nishikawa J, Kanayama T, Dakeyama F, Saito K, Imagawa M, et al. Estrogenic activities of 517 chemicals by yeast two-hybrid assay. J Health Sci 2000;46:282-98.
6. Olea N, Pulgar R, Perez P, Olea-Serrano F, Rivas A, Novillo-Fertrell A, et al. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect 1996;104:298-305.
7. Nagel SC, vom Saal FS, Thayer KA, Dhar MG, Boechler M, Welshons WV. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect 1997;105:70-6.
8. Welshons WV, Nagel SC, Thayer KA, Judy BM, vom Saal FS. Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice. Toxicol Ind Health 1999;15:12-25.
9. Gupta C. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Proc Soc Exp Biol Med 2000;224:61-8.
10. Howdeshell KL, Hotchikiss AK, Thayer KA, Vandenbergh JG, vom Saal FS. Exposure to bisphenol A advances puberty. Nature 1999;401:7634.
11. Honma S, Suzuki A, Buchanan DL, Katsu Y, Watanabe H, Iguchi T. Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction. Reprod Toxicol 2002;16:10716.
12. Ashby J, Tinwell H, Haseman J. Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero. Regul Toxicol Pharmacol 1999;30:15666.
13. Cagan SZ, Waechter Jr JM, Dimond SS, Breslin WJ, Butala JH, Jekat FW, et al. Normal reproductive organ development in DF-1 mice following prenatal exposure to bisphenol A. Toxicol Sci 1999;50:36-44.
14. Kincl FA. Hormone toxicity in the newborn. In: Monographs on endocrinology, vol. 31. Berlin: Springer; 1990. p. 168-93.
15. Ohta Y. Sterility in neonatally androgenized female rats and the decidual cell reaction. Int Rev Cytol 1995;160:1-52.
16. Iguchi T. Cellular effects of early exposure to sex hormones and antihormones. Int Rev Cytol 1992;139:1-57.
17. Iguchi T, Takasugi N. Postnatal development of uterine abnormalities in mice exposed to DES in utero. Biol Neonate 1987;52:97-103.
18. Henry EC, Miller RK, Baggs RB. Direct fetal injections of diethylstilbestrol and 17β-estradiol: a method for investigation their teratogenicity. Teratology 1984;29:297-304.
19. Boylan ES. Morphological and functional consequences of prenatal exposure to diethylstilbestrol in the rat. Biol Reprod 1978;19:854-63.
20. Blake CA, Ashiru OA. Disruption of rat estrous cyclicity by the environmental estrogen 4-tert-octylphenol. Proc Soc Exp Biol Med 1997;216:446-51.
21. Katuda S, Yoshida M, Watanabe G, Taya K, Maekawa A. Irreversible effect of neonatal exposure to p-tert-octylphenol on the reproductive tract in female rats. Toxicol Appl Pharmacol 2000;165:217-26.
22. Nagao T, Saito Y, Usumi K, Kuwagata M, Imai K. Reproductive function in rats exposed neonatally to bisphenol A and estradiol benzoate. Reprod Toxicol 1999;13:303-11.