Encapsulation of plasmid DNA in PLGA-stearylamine microspheres: A comparison of solvent evaporation and spray-drying methods

Journal of Microencapsulation

Volumn 20, Issue 3, 2003, Pages 387-399

  Atuah, K N ^a   Walter, E ^b   Merkle, H P ^b   Alpar, H O ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b ETH ZURICH   (Switzerland)

Author keywords

DNA vaccines; Double emulsion solvent evaporation; PLGA microspheres; Spray drying; Stearylamine

Indexed keywords

DNA VACCINE; LUCIFERASE; MICROSPHERE; OCTADECYLAMINE; PLASMID DNA; POLYGLACTIN;

AGAR GEL ELECTROPHORESIS; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG RELEASE; ELECTROPHORETIC MOBILITY; EMULSION; EVAPORATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; INTERMETHOD COMPARISON; KIDNEY EPITHELIUM; LASER DIFFRACTION; MICROENCAPSULATION; PROTEIN EXPRESSION; REPORTER GENE; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; ZETA POTENTIAL;

AMINES; CELL LINE; DRUG CARRIERS; DRUG COMPOUNDING; ELECTROSTATICS; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; PLASMIDS; POLYGLYCOLIC ACID; POLYMERS; SOLVENTS; SURFACE PROPERTIES; TRANSFECTION; VACCINES, DNA;

EID: 0038784350     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/0265204031000093041     Document Type: Article

References (17)

1. ALPAR, H. O., EYLES, J. E., WILLIAMSON, E. D. and SOMAVARAPU, S., 2001, Intranasal vaccination against plague, tetanus and diphtheria. Advanced Drug Delivery Reviews, 51, 173-201.
2. ALPAR, H. O., OZSOY, Y., BOWEN, J., EYLES, J. E., CONWAY, B. R. and WILLIAMSON, E. D., 1996, Genetic immunisation via mucosal and parenteral routes using microsphere carriers. Proceedings of the International Symposium on Controlled Release of Bioactive Materials, 23, 861-862.
3. CAPAN, Y., WOO, B. H., GEBREKIDAN, S., AHMED, S. and DELUCA, P., 1999, Preparation and characterisation of poly(D,L-lactide-co-glycolide) microspheres for the controlled release of poly(L-lysine) complexed plasmid DNA. Pharmaceutical Research, 16, 509-513.
4. ELDRIDGE, J. H., STAAS, J. K., MEUBROEK, J. A., MCGHEE, J. R., TICE, T. R. and GILLEY, R. M., 1991, Biodegradable microspheres as a vaccine delivery system. Molecular Immunology, 28, 287-294.
5. EYLES, J. E., WILLIAMSON, E. D., SPIERS, I. D., STAGG, A. J., JONES, S. M. and ALPAR, H. O., 1999, Generation of protective immune responses to plague by mucosal administration of microsphere co-encapsulated recombinant subunits. Journal of Controlled Release, 63, 191-200.
6. FLICK-SMITH, H. C., EYLES, J. E., HEBDON, R., WATERS, L. E., BEEDHAM, R. J., STAGG, T. J., MILLER, J., ALPAR, H. O., BAILLIE, L. W. J. and WILLIAMSON, E. D., 2002, Mucosal or parenteral administration of microsphere-associated Bacillus anthracis protective antigen protects against anthrax infection in mice. Infection and Immunity, 70, 2022-2028.
7. JEFFERY, H., DAVIS, S. S. and O'HAGAN, D. T., 1993, The preparation and characterisation of poly(lactide-co-glycolide) microparticles II: the entrapment of a model protein using a (water-in-oil)-in water emulsion solvent evaporation technique. Pharmaceutical Research, 10, 362-368.
8. JOHANSEN, P., MERKLE, H. P. and GANDER, B., 2000, Technological considerations related to the upscaling of protein microencapsulation by spray-drying. European Journal of Pharmaceutics and Biopharmaceutics, 50, 413-417.
9. JONES, D. H., CLEGG, J. C. and FARRAR, G. H., 1998, Oral delivery of micro-encapsulated DNA vaccines. Developments in Biological Standardization, 92, 149-155.
10. MCGEE, J. P., SINGH, M., LI X.-M., QIU, H. and O'HAGAN, D. T., 1997, The encapsulation of a model protein in poly (D,L lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility. Journal of Microencapsulation, 14, 197-210.
11. OGAWA, Y., YAMAMOTO, M., OKADA, H., YASHIKI, T. and SHIMAMOTO, T., 1988, A new technique to efficiently entrap leuprolide acetate into microspheres of polylactic acid or co-poly (lactic/glycolic) acid. Chemical and Pharmaceutical Bulletin Tokyo, 36, 1095-1103.
12. TABATA, Y. and IKADA, Y., 1988, Macrophage phagocytosis of biodegradable microspheres composed of L-lactic-acid/glycolic acid homo- and copolymers. Journal of Biomedical Materials Research, 22, 837-858.
13. TABATA, Y. and IKADA, Y., 1990, Phagocytosis of polymer microspheres by macrophages. Advances in Polymer Science, 94, 107-141.
14. WALTER, E., DREHER, D., KOK, M., THIELE, L., KIAMA, S. G., GEHR, P. and MERKLE, H. P., 2001, Hydrophilic poly(DL-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells. Journal of Controlled Release, 76, 149-168.
15. WALTER, E., MOELLING, K., PAVLOVIC, J. and MERKLE, H. P., 1999, Microencapsulation of DNA using poly(DL-lactide-co-glycolide): stability issues and release characteristics. Journal of Controlled Release, 61, 361-374.
16. WANG, D., JING, N.-H. and LEN, Q.-S., 1996, Stearylamine liposome as a new efficient reagent for DNA, transfection of eukaryotic cells. Biochemical and Biophysical Research Communications, 226, 450-455.
17. ZHOU, X. and HUANG, L., 1994, DNA transfection mediated by cationic liposomes containing lipopolysine: characterisation and mechanism of action. Biochimica et Biophysica Acta, 1189, 195-203.