Effects of long-term theophylline exposure on recovery of respiratory function and expression of adenosine A1 mRNA in cervical spinal cord hemisected adult rats

Experimental Neurology

Volumn 182, Issue 1, 2003, Pages 232-239

  Nantwi, Kwaku D ^a   Basura, Gregory J ^a   Goshgarian, Harry G ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine A1 receptor mRNA; Cervical spinal cord injury; Functional recovery; Respiration; Theophylline

Indexed keywords

ADENOSINE A1 RECEPTOR; DRUG VEHICLE; MESSENGER RNA; THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CERVICAL SPINAL CORD; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CONVALESCENCE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EXPOSURE; DRUG WITHDRAWAL; ELECTROPHYSIOLOGY; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INJURY; LONG TERM EXPOSURE; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RECORDING; RESPIRATORY AIRFLOW; RESPIRATORY FUNCTION; SPINAL CORD HEMISECTION; SPINAL CORD INJURY; STANDARD; WEANING;

EID: 0038772002     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4886(03)00109-2     Document Type: Article

References (28)

1. Aserinsky E. Effects of usage of a dormant respiratory nerve pathway upon its subsequent activity. Exp. Neurol. 3:1961;467-475.
2. Basura G.J., Zhou S.-Y., Walker P.D., Goshgarian H.G. Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic motoneurons following spinal cord hemisection. Exp. Neurol. 169:2001;255-263.
3. Basura G.J., Nantwi K.D., Goshgarian H.G. Theophylline-induced respiratory recovery following cervical spinal cord hemisection is augmented by serotonin 2 receptor stimulation. Brain Res. 956:2002;1-13.
4. Dixon A.K., Guvitz A.K., Sirinathsinghji D.J., Richardson P.J., Freeman T.C. Tissue distribution of adenosine receptor mRNA in the rat. Br. J. Pharmacol. 118:1996;1461-1468.
5. Dong X.-W., Feldman J.L. Modulation of inspiratory drive to phrenic motoneurons by presynaptic adenosine A1 receptors. J. Neurosci. 15:1995;3458-3467.
6. Fastbom J., Fredholm B.B. Effects of long term theophylline treatment on adenosine A1-receptors in rat brain autoradiographic evidence for increased receptor number and altered coupling to G-proteins . Brain Res. 507:1990;195-199.
7. Goldberger M., Murray M. Restitution of function and collateral sprouting in cat spinal cord the deafferented animal . J. Comp. Neurol. 158:1974;37-54.
8. Gould D.J., Goshgarian H.G. Glial changes in the phrenic nucleus following superimposed cervical spinal cord hemisection and peripheral chronic phrenicotomy injuries in adult rats. Exp. Neurol. 148:1997;1-9.
9. Goshgarian H.G. Development plasticity in the respiratory pathway of the adult rat. Exp. Neurol. 66:1979;547-555.
10. Guth L. Functional plasticity in the respiratory pathway of the mammalian spinal cord. Exp. Neurol. 51:1976;414-420.
11. Hadley S.D., Walker P.D., Goshgarian H.G. Effects of the Serotonin synthesis inhibitor p-CPA on the expression of the crossed phrenic phenomenon 4 h following C2 spinal cord hemisection. Exp. Neurol. 160:1998;446-453.
12. Jacobson K.A., von Lubitz D.K., Daly J.E., Fredholm B.B. Adenosine receptor ligands differences with acute versus chronic treatment . Trends Pharmacol. Sci. 17:1996;108-113.
13. Johansson B., Ahlberg S., Van der Ploeg I., Brene S., Lindefors N. Effects of long term caffeine treatment on A1 and A2 adenosine receptor binding and on mRNA levels in rat brain. Naunyn-Sch. Arch. Pharmacol. 347:1993;407-414.
14. Johansson B., Georgiev V., Lindstrom K., Fredholm B.B. A1 and A2 adenosine receptors and A1 mRNA in mouse brain effect of longterm caffeine treatment . Brain Res. 762:1997;153-164.
15. Ling L., Bach K.B., Mitchell G.S. Serotonin reveals ineffective spinal pathways to contralateral phrenic motoneurons in spinally hemisected rats. Exp. Brain Res. 101:1994;35-43.
16. Little J.W., Harris R.M., Sohlberg R.C. Locomotor recovery following subtotal spinal cord lesions in a rat model. Neurisci. Lett. 87:1987;189-194.
17. McKinley W.O. Late return of diaphragm function in a ventilator-dependent patient with a high cervical tetraplegia case report and interactive review . Spinal Cord. 34:1996;626-629.
18. Moreno D.E., Yu X., Goshgarian H.G. Identification of the axon pathways which mediate functional recovery of a paralyzed hemidiaphragm following spinal cord hemisection in the adult rat. Exp. Neurol. 116:1992;219-228.
19. Nantwi K.D., El-Bohy A.A., Schrimsher G.W., Reier P.J., Goshgarian H.G. Spontaneous functional recovery in a paralyzed hemidiaphragm following upper cervical spinal cord injury in adult rats. Neurorehab. Neural Rep. 13:(4):1999;225-2345.
20. Nantwi K.D., Goshgarian H.G. Effects of chronic systemic theophylline injections on recovery of hemidiaphragmatic function after cervical spinal cord injury in adult rats. Brain Res. 789:1998;126-129.
21. Nantwi K.D., Goshgarian H.G. Theophylline-induced recovery in a hemidiaphragm paralyzed by hemisection in rats contribution of adenosine receptors. Neuropharmacology. 37:1998;113-121.
22. Nantwi K.D., Goshgarian H.G. Alkylxanthine-induced recovery of respiratory function following cervical spinal cord injury in adult rats. Exp. Neurol. 168:2001;123-134.
23. Reppert S.M., Weaver D.R., Stehle J.H., Rivkees S.A. Molecular cloning and characterization of a rat adenosine A1-adenosine receptor that is widely expressed in brain and spinal cord. Mol. Endocrinol. 5:1991;1037-1048.
24. Shi D., Daly J.W. Chronic effects of Xanthines on levels of central receptors in mice. Cell. Mol. Neurobiol. 19:(6):1999;719-732.
25. Thummer S., Dunwiddie T.V. Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA-receptor dependent mechanism. J. Neurophysiol. 83:(4):2000;1787-1795.
26. Zhou S.-Y., Goshgarian H.G. Effects of serotonin on crossed phrenic nerve activity in cervical spinal cord hemisected rats. Exp. Neurol. 160:1999;446-453.
27. Zhou S.-Y., Goshgarian H.G. 5-Hydroxytryptophan-induced respiratory after cervical spinal cord hemisection in rats. J. Appl. Physiol. 89:2000;1528-1536.
28. Zhou S.-Y., Basura G.J., Goshgarian H.G. Involvement of serotonin 2 receptors in respiratory recovery following cervical spinal cord hemisection in adult rats. J. App. Phys. 91:(6):2001;2665-2673.